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The information given in this book tries to capture the essence of
the sheer dynamicity of the cell along with useful tips on how to
address critical rate limiting steps in the process of exploration
and investigation of its capacity to regenerate, rebuild and
replenish from within. The definitions of stem cells, stemness, and
the niche concept continue to undergo revisions. In adult
vertebrates, hematopoietic and some non-hematopoietic progenitors
are synthesized within specialized niches of bone marrow. They
migrate to designated tissues, and are either trans-differentiated
or become quiescent and settle down. These form the stem cell niche
reservoir in all tissues. Not only the primary hematopoietic tissue
but all organs and tissues are also capable of generating
progenitors which are either synthesized from these migrants or are
direct recruits from other tissues. In the niches, the cells settle
down and await their turn to either make more clones like
themselves or differentiate and mobilize in an exigency. Thus
progenitors are important reserves, to be multiplied and deployed
or travel as important message bearing molecules via blood as
circulating progenitors which can home to their allocated
destinations. Upon reaching, specific integrins and selectins help
them “dock” and “port” and they may be reprogrammed to
induce further differentiation and help repopulate the denuded
tissue. In pulmonary fibrosis and asthma, progenitors from both
systemic circulation and local stem cell niches have been found to
participate in the myriad ramifications of repair, replacement and
regeneration of lost or diseased tissue. Whether they are lung
specific or global in origin and role remain to be explored.
Research tools, fundamental concepts, techniques, methodologies and
standard operating protocols and animal models and human
extrapolations, have been discussed in a concise way along with
detailed description and discussion on the appropriate rationale to
introduce the subject to the casual reader and provide valuable
tactical information to the specialist in Regenerative Medicine. I
sincerely hope you enjoy the work and appreciate the hard work that
has gone into designing and executing elegant experiments by many
researchers in the field. The branch is multi-disciplinary and I
hope that the readers will not be limited to biologists alone.
“Perspectives in Inflammation Biology” outlines detailed
studies using preclinical murine models in Inflammation. The book
is meant for academicians, industry persons, research scholars and
students alike. The detailed perspective for a beginner and the
exhaustive methodologies and analyses outlined, for the veteran
researcher, makes this book a unique link between someone who is
thinking of embarking on a study of inflammation and one who is
delving deep into this area of specialization. The book deals with
asthma and allergy as specific disease areas of inflammation of the
lung, aseptic peritonitis as a disease of systemic inflammation and
details how each role player in its pathophysiology has a unique
niche of activity. Data acquisition, sequentiality and analyses in
context demonstrate how each role player is validated
systematically to become a target for drug discovery. Methods and
models used in the course of my work and their relevance will
demonstrate to the researcher how a study can be developed from an
idea. Further into a researcher’s ongoing work, this book is
meant to stimulate new questions and pave ways for better
dissection of a phenomenon. The highlights of this book are the
detailed tables tabulating sub species of immune cells, their
inflammatory recruitment indices, their translation into
tissue-to-tissue traffic of the inflammatory stimulus and the
delicate interplay of resident structural cells, cells recruited
from circulation, their feedback poiesis in bone marrow, their
instruction in the lymphoid organs and tissues as well as the
non-cellular mediators synthesized from corresponding genetic
instruction. The book shall definitely help students and
researchers how a disease can be simplified from its complex
ramifications and network of implications and put back into
perspective and the whole thing falls into place without an
intimate understanding of the mechanism and the compelling
circumstances that causes a disease, a drug hunter cannot hope to
begin her quest. To find the “Achilles’ heel” and effectively
neutralize the enemy!
The information given in this book tries to capture the essence of
the sheer dynamicity of the cell along with useful tips on how to
address critical rate limiting steps in the process of exploration
and investigation of its capacity to regenerate, rebuild and
replenish from within. The definitions of stem cells, stemness, and
the niche concept continue to undergo revisions. In adult
vertebrates, hematopoietic and some non-hematopoietic progenitors
are synthesized within specialized niches of bone marrow. They
migrate to designated tissues, and are either trans-differentiated
or become quiescent and settle down. These form the stem cell niche
reservoir in all tissues. Not only the primary hematopoietic tissue
but all organs and tissues are also capable of generating
progenitors which are either synthesized from these migrants or are
direct recruits from other tissues. In the niches, the cells settle
down and await their turn to either make more clones like
themselves or differentiate and mobilize in an exigency. Thus
progenitors are important reserves, to be multiplied and deployed
or travel as important message bearing molecules via blood as
circulating progenitors which can home to their allocated
destinations. Upon reaching, specific integrins and selectins help
them "dock" and "port" and they may be reprogrammed to induce
further differentiation and help repopulate the denuded tissue. In
pulmonary fibrosis and asthma, progenitors from both systemic
circulation and local stem cell niches have been found to
participate in the myriad ramifications of repair, replacement and
regeneration of lost or diseased tissue. Whether they are lung
specific or global in origin and role remain to be explored.
Research tools, fundamental concepts, techniques, methodologies and
standard operating protocols and animal models and human
extrapolations, have been discussed in a concise way along with
detailed description and discussion on the appropriate rationale to
introduce the subject to the casual reader and provide valuable
tactical information to the specialist in Regenerative Medicine. I
sincerely hope you enjoy the work and appreciate the hard work that
has gone into designing and executing elegant experiments by many
researchers in the field. The branch is multi-disciplinary and I
hope that the readers will not be limited to biologists alone.
"Perspectives in Inflammation Biology" outlines detailed studies
using preclinical murine models in Inflammation. The book is meant
for academicians, industry persons, research scholars and students
alike. The detailed perspective for a beginner and the exhaustive
methodologies and analyses outlined, for the veteran researcher,
makes this book a unique link between someone who is thinking of
embarking on a study of inflammation and one who is delving deep
into this area of specialization. The book deals with asthma and
allergy as specific disease areas of inflammation of the lung,
aseptic peritonitis as a disease of systemic inflammation and
details how each role player in its pathophysiology has a unique
niche of activity. Data acquisition, sequentiality and analyses in
context demonstrate how each role player is validated
systematically to become a target for drug discovery. Methods and
models used in the course of my work and their relevance will
demonstrate to the researcher how a study can be developed from an
idea. Further into a researcher's ongoing work, this book is meant
to stimulate new questions and pave ways for better dissection of a
phenomenon. The highlights of this book are the detailed tables
tabulating sub species of immune cells, their inflammatory
recruitment indices, their translation into tissue-to-tissue
traffic of the inflammatory stimulus and the delicate interplay of
resident structural cells, cells recruited from circulation, their
feedback poiesis in bone marrow, their instruction in the lymphoid
organs and tissues as well as the non-cellular mediators
synthesized from corresponding genetic instruction. The book shall
definitely help students and researchers how a disease can be
simplified from its complex ramifications and network of
implications and put back into perspective and the whole thing
falls into place without an intimate understanding of the mechanism
and the compelling circumstances that causes a disease, a drug
hunter cannot hope to begin her quest. To find the "Achilles' heel"
and effectively neutralize the enemy!
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