This new edition of the book series dedicated to "Progress in Epileptic Disorders" is the result of a recently held unique gathering of international experts that debated on the prognostic and therapeutic issues raised by the new management of first unprovoked seizures and of newly diagnosed epilepsy. Current knowledge on natural evolution of a first seizure, the role of co-morbid conditions, the impact of immediate versus delayed treatment and recent guidelines are thoroughly addressed. The new ideas and suggestions that emerge from this book offer challenging perspectives for both patient care and clinical as well as fundamental research.