In this issue of Otolaryngologic Clinics, guest editors Drs. Romaine F. Johnson and Elton M. Lambert bring their considerable expertise to the topic of Pediatric Otolaryngology. Top experts in the field cover key topics such as single-sided deafness, eustachian tube dysfunction, drug-induced sleep endoscopy; drooling and aspiration; pediatric tracheostomy teams; 3-D printing in otolaryngology; and more. Contains 15 relevant, practice-oriented topics including enhanced recovery after surgery; aerodigestive approaches to chronic cough; slide tracheoplasty: tracheal rings and beyond; COVID-19 and pediatric otolaryngology; and more. Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

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This multidisciplinary guide to the literature and research about the physical and psychological aspects of successful, normal, and productive aging is designed for students, teachers, and practitioners who deal with the elderly. The introduction discusses perceptions of aging well. The 500 entries are arranged alphabetically by author under nine topics: physical aging, psychological aging, social aging, family, living arrangements, work and economics, education and leisure, politics, and religion. An appendix covers sources dealing with the measurement of aging well. The careful author and subject indexes make this annotated bibliography easy-to-use for researchers in the fields of history, economics, psychology, sociology, law, theology, demography, public health, political science, home economics, family studies, women's studies, pharmacy, and health administration, among others.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Key Features
* Human Genomics and Genetics
* Structure and Mechanism
* Regulation of Expression
* Metabolism
* Invertibrate P450s

As microarray technology has matured, data analysis methods have advanced as well. Methods Of Microarray Data Analysis III is the third book in this pioneering series dedicated to the existing new field of microarrays. While initial techniques focused on classification exercises (volume I of this series), and later on pattern extraction (volume II of this series), this volume focuses on data quality issues. Problems such as background noise determination, analysis of variance, and errors in data handling are highlighted.

Three tutorial papers are presented to assist with a basic understanding of underlying principles in microarray data analysis, and twelve new papers are highlighted analyzing the same CAMDA'02 datasets: the Project Normal data set or the Affymetrix Latin Square data set. A comparative study of these analytical methodologies brings to light problems, solutions and new ideas. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state of art of microarray data analysis.

This book offers critical readings of issues in education and technology and demonstrates how researchers can use critical perspectives from sociology, digital media, cultural studies, and other fields to broaden the "ed-tech" research imagination, open up new topics, ask new questions, develop theory, and articulate an agenda for informed action.

Microarray technology is a major experimental tool for functional genomic explorations, and will continue to be a major tool throughout this decade and beyond. The recent explosion of this technology threatens to overwhelm the scientific community with massive quantities of data. Because microarray data analysis is an emerging field, very few analytical models currently exist. Methods of Microarray Data Analysis is one of the first books dedicated to this exciting new field. In a single reference, readers can learn about the most up-to-date methods ranging from data normalization, feature selection and discriminative analysis to machine learning techniques. Currently, there are no standard procedures for the design and analysis of microarray experiments. Methods of Microarray Data Analysis focuses on two well-known data sets, using a different method of analysis in each chapter. Real examples expose the strengths and weaknesses of each method for a given situation, aimed at helping readers choose appropriate protocols and utilize them for their own data set. In addition, web links are provided to the programs and tools discussed in several chapters. This book is an excellent reference not only for academic and industrial researchers, but also for core bioinformatics/genomics courses in undergraduate and graduate programs.

Johnson addresses ethical issues in aging in a variety of contexts--the social cultural environment, physical health care, mental health care, social health care, legal care, and spiritual care. Because long-term aging has created a new generation of older adults, some new issues are emerging which need to be addressed from an ethical perspective--elder abuse, physician assisted suicide, dementia, intergenerational equity, guardianship, and living wills. A wide range of experts including physicians, philosophers, lawyers, social workers, nurses, sociologists, public health persons, theologians, historians, and ethicists share their insights on the ethical issues and dilemmas older adults in American society are facing or are likely to face over the life course. Of interest to undergraduate and graduate faculty and students in sociology, social work and social services practitioners, policymakers, and academic and professional libraries.

Arthurian Literature has established its position as the home for a great diversity of new research into Arthurian matters. It delivers fascinating material across genres, periods, and theoretical issues. TIMES LITERARY SUPPLEMENT The richness and interdisciplinarity of the Arthurian tradition are well represented by the essays collected here, which range from early Celtic texts to twentieth-century children's books, and include discussion of Welsh, Irish,English, French and Latin material in both literary and historical contexts. Many of the articles focus on less well-known late medieval versions of the legend, a somewhat neglected area until recently: an Irish Grail narrative, the Burgundian prose Erec, the enormous prequel Perceforest, Ysaie le Triste, Le Conte du Papegau, and Froissart's Melyador (the last three discussed as exercises in nostalgia). Meanwhile, anotherchapter approaches Sir Gawain and the Green Knight from the perspective of forest ecology. The contributions represent expanded and revised versions of selected papers given at the XXIIIrd Triennial Congress of the International Arthurian Society held in Bristol in July 2011; they include two of the plenary lectures, one on "Celtic Magic" and one on the reception of Geoffrey of Monmouth in the eighteenth and nineteenth centuries. Elizabeth Archibald is Professor of English Studies at Durham University, and Principal of St Cuthbert's Society; David F. Johnson is Professor of English at Florida State University, Tallahassee. Contributors: Richard Barber, Nigel Bryant, Aisling Byrne, Carol J. Chase, Sian Echard, Helen Fulton, Michael W. Twomey, Patricia Victorin.

The continued influence and significance of the legend of Arthur are demonstrated by the articles collected in this volume. The enduring appeal and rich variety of the Arthurian legend are once again manifest here. Chretien's Erec et Enide features first in a case study of the poet's endings and medieval theories of poetic composition. Next follows an essay that comes to the rather surprising-but- convincing conclusion that the "traitor" spoken of in the opening lines of Sir Gawain and the Green Knight is neither Aeneas nor Antenor, but Paris. Another essay dealing with Sir Gawain, this time in Malory's Morte Darthur, offers among other things an answer to the question of how Gawain knows the exact hour of his death. Few native Irish Arthurian tales have come down to us: a discussion of "The Tale of the Crop-Eared Dog" shows it to be both bizarre and popular, as witnessed by the many manuscripts in which it is preserved. The materiality of the Arthurian legend is represented here by a detailed treatment of the lead cross supposedly found in the grave of King Arthur at Glastonbury Abbey in 1191. Finally, this volume continues Arthurian Literature's tradition of publishing unfamiliar or previously unknown Arthurian texts, in this instance an original Middle English translation of the story of the sword in the stone, from the Old French Merlin. ELIZABETH ARCHIBALD is Professor of English Studies at Durham University, and Principal of StCuthbert's Society; DAVID F. JOHNSON is Professor of English at Florida State University, Tallahassee. Contributors: Lindy Brady, David Carlton, Neil Cartlidge, Nicole Clifton, Oliver Harris, Richard Moll, Rebecca Newby.

Arthurian Literature has established its position as the home for a great diversity of new research into Arthurian matters. Delivers some fascinating material across genres, periods, and theoretical issues. TIMES LITERARY SUPPLEMENT The influence and significance of the legend of Arthur are fully demonstrated by the subject matter and time-span of articles here. Topics range from early Celtic sources and analogues of Arthurian plots to popular interest in King Arthur in sixteenth-century London, from the thirteenth-century French prose Mort Artu to Tennyson's Idylls of the King. It includes discussion of shapeshifters and loathly ladies, attitudes to treason, royal deaths and funerals in the fifteenth century and the nineteenth, late medieval Scottish politics and early modern chivalry. Elizabeth Archibald is Professor of English, University of Durhaml; Professor David F. Johnson teaches in the English Department, Florida State University, Tallahassee. Contributors: Aisling Byrne, Emma Campbell, P.J.C. Field, Kenneth Hodges, Megan Leitch, Andrew Lynch, Sue Niebrzydowski, Karen Robinson.

Arthurian Literature has established its position as the home for a great diversity of new research into Arthurian matters. It delivers fascinating material across genres, periods, and theoretical issues. TIMES LITERARY SUPPLEMENT The studies collected in this volume demonstrate the enduring vitality of the Arthurian legend in a wide range of places, times and media. Chretien's Conte du Graal features first in a study of the poem's place in its Anglo-Norman context, followed by four essays on Malory's Morte Darthur. Two of these deal with the significance of wounds and wounding in Malory's text, while the third explores the problematic aspects of sleep and the "slepynge knight" in that same romance. The fourth considers "transformative female corpses" as, quite literally, the embodiment of critical comment on the chivalric community in the Morte Darthur. There follow two studies of the Arthurian legend captured in material objects: the first concerns the early twelfth-century images on a marble column from the cathedral at Santiago de Compostela, the second a twentieth-century tapestry created by Lady Trevelyan for the family home at Wallington Hall. The volume closes with an essay that brings us into the twenty-first century, with an assessment of Kaamelott, an irreverent French Pythonesque television series. ElizabethArchibald is Professor of English Studies at Durham University, and Principal of St Cuthbert's Society; David F. Johnson is Professor of English at Florida State University, Tallahassee. Contributors: Karen Cherewatuk,Tara Foster, Joan Tasker Grimbert, Erin Kissick, Irit Ruth Kleiman, Megan Leitch, Roger Simpson, K.S. Whetter.

Eine grosse Anzahl heterocyclischer Naturstoffe leitet sich vom Ring- system des Piperidins (1) ab. Als Substituenten einfach oder mehrfach substituierter Piperidinbasen finden sich Methyl-, Carboxyl-, Hydroxyl- und Aminogruppen sowie aliphatische Seitenketten unterschiedlicher Lange. Die Substitution erfolgt bevorzugt an den C-Atomen 2, 3 und 6 sowie am Heteroatom. In zahlreichen Fallen ist der Piperidinring in a- oder ss-Stellung direkt oder uber eine C-Brucke mit einem weiteren Heterocyclus verbunden, z. B. einem Piperidin-, Piperidein-, Pyridin-, Indol-, Chinolizidin- oder Furanrest. Daruber hinaus kann der Piperidin- ring zum 2,6-Dioxopiperidin (Glutarimid) oxydiert oder zum Pipendein dehydriert sein. Wahrend Naturstoffe mit Pyridinstruktur im Tier- und Pflanzenreich weit verbreitet sind und einzelnen von ihnen wie NAD oder Pyridoxal- phosphat als Coenzymen des Primarstoffwechsels besondere Bedeutung zukommt, handelt es sich bei den naturlichen Piperidinverbindungen im allgemeinen um sekundare Pflanzenstoffe (vgl. I8, I9I). Dabei sind einige wie z. B. die Pipecolinsaure (7) sporadisch auf verschiedene Pflanzen- familien verteilt. Andere Piperidinbasen wie die Conium- oder Piper- Alkaloide weisen dagegen eine ausgesprochene Artspezifitat auf. Im Gegensatz zu den meisten Pyridinalkaloiden finden sich die Piperidin- basen oft mit strukturell andersartig gebauten Alkaloiden vom Chino- lizidin- oder Trepantyp vergesellschaftet, was in den meisten Fallen durch eine enge biogenetische Verwandtschaft bedingt sein durfte.

Microarray technology is a major experimental tool for functional genomic explorations, and will continue to be a major tool throughout this decade and beyond. The recent explosion of this technology threatens to overwhelm the scientific community with massive quantities of data. Because microarray data analysis is an emerging field, very few analytical models currently exist. Methods of Microarray Data Analysis II is the second book in this pioneering series dedicated to this exciting new field. In a single reference, readers can learn about the most up-to-date methods, ranging from data normalization, feature selection, and discriminative analysis to machine learning techniques.

Currently, there are no standard procedures for the design and analysis of microarray experiments. Methods of Microarray Data Analysis II focuses on a single data set, using a different method of analysis in each chapter. Real examples expose the strengths and weaknesses of each method for a given situation, aimed at helping readers choose appropriate protocols and utilize them for their own data set. In addition, web links are provided to the programs and tools discussed in several chapters. This book is an excellent reference not only for academic and industrial researchers, but also for core bioinformatics/genomics courses in undergraduate and graduate programs.

Arthurian Literature has established its position as the home for a great diversity of new research into Arthurian matters. It delivers fascinating material across genres, periods, and theoretical issues. TIMES LITERARY SUPPLEMENT The essays collected here put considerable emphasis on Arthurian narratives in material culture and historical context, as well as on purely literary analysis, a reminder of the enormous range of interests in Arthurian narrativesin the Middle Ages, in a number of different contexts. The volume opens with a study of torture in texts from Chretien to Malory, and on English law and attitudes in particular. Several contributors discuss the undeservedly neglected Stanzaic Morte Arthur, a key source for Malory. His Morte Darthur is the focus of several essays, respectively on the sources of the "Tale of Sir Gareth"; battle scenes and the importance of chivalric kingship; Cicero's De amicitia and the mixed blessings and dangers of fellowship; and comparison of concluding formulae in the Winchester Manuscript and Caxton's edition. Seven tantalizing fragments of needlework, all depictingTristan, are discussed in terms of the heraldic devices they include. The volume ends with an update on newly discovered manuscripts of Geoffrey of Monmouth's seminal Historia regum Britanniae, the twelfth-century best-seller which launched Arthur's literary career. Elizabeth Archibald is Professor of English Studies at Durham University, and Principal of St Cuthbert's Society; David F. Johnson is Professor of English at Florida State University, Tallahassee. Contibutors: David Eugene Clark, Marco Nievergelt, Ralph Norris, Sarah Randles, Lisa Robeson, Richard Severe, Jaakko Tahkokallio, Larissa Tracy

This book takes a fresh look at understanding how financial markets behave. Using recent ideas from the highly-topical science of complexity and complex systems, the book provides the basis for a unified theoretical description of how today's markets really work. Since financial markets are an excellent example of a complex system, the book also doubles as a science textbook.

New and fresh assessments of Malory's Morte Darthur. The essays here are devoted to that seminal Arthurian work, Sir Thomas Malory's Le Morte Darthur. Developments of papers first given at the 'Malory at 550: Old and New' conference, they emphasise here the second part of its remit. Accordingly, several contributors focus new attention on Malory's style, using his stock phrases, metaphors, characterization, or manipulation of sources to argue for a deeper appreciation of his merits as an author. If, as others illustrate, Malory is a much better artist than his twentieth-century reputation allowed, then there is a renewed need to re-assess the vexed question of the possible originality of his 'Tale of Sir Gareth of Orkeney'. Similarly fresh approaches underlie those essays re-examining Malory's attitude to time and the sacred in 'The Sankgreal', the manner in which the ghosts of Lot and his sons highlight potential failures in the Round Table Oath, or the pleasures and pitfalls of Arthurian hospitality. The remaining contributions argue for new approaches to Malory's narrative gaps, Launcelot's status as a victim of sexual violence, and the importance of rejecting Victorian moral attitudes towards Gwenyvere and Isode, moralizing that still informs much recent scholarship addressing Malory's female characters. Contributors: Joyce Coleman, Elizabeth Edwards, Kristina Hildebrand, Cathy Hume, David F. Johnson, Megan Leitch, Andrew Lynch, Molly A. Martin, Cory James Rushton, Fiona Tolhurst, Michael W. Twomey

Mistreatment of the elderly became recognized as a serious and growing problem in the late 1970s, as a result of governmental investigations and research in the public and private sectors. Although in most states elder mistreatment is handled by social service agencies, other professionals are also needed to broaden the identification team and help alleviate the risk to the older adults. This book is designed for human services professionals who are not necessarily adult protective services specialists, but who provide direct ongoing services to elder adults. Its purpose is to offer guidelines for detecting elder mistreatment, so that assistance can be given to the vulnerable older adults to preserve their particular quality of life. The book is arranged into seven chapters. The first discusses why elder-serving human services professionals should become involved in mistreatment identification, while chapter two focuses on the various starting points in the definition of elder mistreatment. Chapters three and four review research on risk factors in elder mistreatment and detail varieties of mistreatment measures and methods for distinguishing between them. A review of risk instruments used in adult protective services and non-adult protective services settings forms the basis of chapter five, and chapter six outlines a proposed risk assessment model, specially designed for elder-serving human service professionals. The final chapter offers some prospects for the future of elder mistreatment risk assessments. The work concludes with a set of four appendices, covering contact persons in lead agencies, report-receiving authorities within jurisdictions, health status risk assessment, and prevention strategies. This volume will be a useful tool for human services professionals, mental health care providers, and social health care and legal services professionals, as well as a useful addition to reference collections in public, academic, and medical libraries.