This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Roughly half of all project managers have to lead customer projects as profit centers on contractor side with two big objectives: making the customer happy and bringing money home. Customer projects are a high-risk business on both sides, customers and contractors, but the dynamics of this business have so far been mostly ignored in literature. The book is intended to fill this gap. The book helps project managers better understand the dynamics of customer projects under contract from business development through handover and find solutions for common problems. A central aspect is international contract laws, an often underestimated factor in projects.

Most project managers would agree that every project is unique. But not all project managers would agree that the best way to manage a unique project is unique. Many still cling to the old practice of having a methodology that is applied to all projects. "One size fits all" is still in common use, and this approach has proven to lead to project failure. Flexibility, situational intelligence, and creativity are essential to deliver project success. The need to recognize and master ever-changing requirements and environmental conditions is a tough challenge for professional project managers. The same practices that led to success yesterday may cause failure today. Selecting favorable responses to a given situation is often the most critical factor of the dynamics of success and failure. This book is designed to help project professionals assess a situation, predict the appropriate approach, methodology and achieving styles, and then apply them in a situational fashion. To guide project managers in selecting the appropriate responses, Situational Project Management (SitPM) shows how to assess a given project, determine its unique characteristics, and select the appropriate methods to complete the project. With this book, projects managers can use SitPM to develop profiles of their projects on the basis of the projects' physical characteristics, the project teams' behavioral characteristics, the enterprise environment, and the market environments receiving project deliverables. These profiles help project managers to determine the appropriate project life cycle approach and leadership style. The book also explores various ways to engage stakeholders on the basis of a project's SitPM profile. The book's author, Oliver F. Lehmann, has developed a set of templates to apply SitPM in practice. It can be downloaded from www.oliverlehmann.com/SitPM/Templates.zip.

Roughly half of all project managers have to lead customer projects as profit centers on contractor side with two big objectives: making the customer happy and bringing money home. Customer projects are a high-risk business on both sides, customers and contractors, but the dynamics of this business have so far been mostly ignored in literature. The book is intended to fill this gap. The book helps project managers better understand the dynamics of customer projects under contract from business development through handover and find solutions for common problems. A central aspect is international contract laws, an often underestimated factor in projects.

S. Geley,M. Fiegl, B.L. Hartmann, R. Kofler: Genes Mediating Glucocorticoid Effects and Mechanisms of Their Regulation J.O. Holloszy, P.A. Hansen: Regulation of Glucose Transport into Skeletal Muscle F. Lehmann-Horn, R. Rudel: Molecular Pathophysiology of Voltage-Gated Ion Channels

I. Introduction Of the ever increasing number of viruses known to affect man and higher animals, the virus of lymphocytic choriomeningitis (LCM) was one of the first to be discovered. Indeed, this virus has been known and maintained in the laboratory by passages in a relatively simple host, the mouse, for 35 years. Yet our knowl edge of its properties is still scanty when compared with the wealth of informa tion available for other viruses, some of which have come to our attention much more recently. There are at least four reasons which may help to explain this seeming paradox. (1) The early belief that the LCM virus was the frequent cause of human diseases had soon to be abandoned; infections of man with this virus are rare. (2) By way of contrast, laboratory infections are not uncommon and they frequently run severe and even fatal courses. (3) Until recently, the only means of titrating the virus was by mouse inoculation, a method in which accuracy and economy are poorly correlated. (4) The virus is of unusual lability, being quickly inactivated under conditions which leave other viruses intact. Thus, when balancing medical and theoretical importance against personal hazard and tech nical difficulties, the result was quite unfavorable, and lack of interest was really not surprising. In the last few years, however, the situation has gradually changed and an increasing number of workers have turned their attention to this virus."

This book prepares readers to master an IT and managerial discipline quickly gaining momentum in organizations of all sizes - Business Process Management (BPM). It describes how BPM treats processes as a portfolio of strategic assets that create and deliver customer and shareholder value and adapt, when necessary, enabling competitive advantage through consistent performance. Strategy and Business Process Management: Techniques for Improving Execution, Adaptability, and Consistency defines the planning framework and managerial mindset necessary to craft and drive highly effective business process improvement projects and continuous improvement programs. Readers will learn specific techniques used by industry leaders to formulate and execute business strategy that adapts organizational behavior, business processes, and information technology as a dynamic system designed to assure consistent performance and achievement, even when challenged with unexpected changes or opportunities.

Der Gedanke zu diesem neuen Randbuche ist der Erkenntnis und Uber zeugung entsprungen, daB es nicht nur zeitgemaB und niitzlich, sondern fiir den Fortschritt in der Theorie und Praxis der Tierernahrung heute auch un bedingt notwendig sei, neben den zahlreichen Biichern iiber Fiitterungslehre ein Werk zu schaffen, das die chemischen, physiologischen und biologischen Grundlagen der Fiitterungslehre zusammenfassend darstellt. Etwas Derartiges fehlte bisher vollkommen und ist doch zweifellos ein Bediirfnis fiir die vielen Landwirte und Tierarzte, Physiologen und Chemiker, die sich jetzt in allen Landern der Welt wissenschaftlich mit der Ernahrung und Fiitterung der land wirtschaftlichen Nutztiere befassen. Insbesondere besteht zur Zeit fiir die Versuchsstationen und Forschungsinstitute dieser Richtung keine Moglichkeit, ihren Mitgliedern ein Werk an die Hand zu geben, das ihnen die physiologischen Grundlagen der Fiitterungslehre vermittelt, ohne die ihre Arbeit des tieferen Verstandnisses ermangeln und groBenteils Empirie bleiben muB. In den meisten Lehr- und Randbiichern der Physiologie finden sich Angaben iiber die Lebens funktionen und besonders die Ernahrung der landwirtschaftlichen Tiere nur kurz zusammengefaBt oder weit verstreut; in den Werken iiber Tierzucht wird Ernahrung und Stoffwechsel auf wenigen Seiten und nur die spezielle Fiitterungs praxis fiir die einzelnen Tierarten ausfiihrlicher behandelt."