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"Democratic Spain" is the first thorough study of democratic
Spain's re-emergence on the international scene.Since the death of
General Franco in 1975, Spain has emerged from relative isolation
to play an active role in international affairs. Membership of the
European Union and Nato have been keys to Spain's new prominence,
although the country has also tried to build on its traditional
"special relationships" with Latin America and the Arab world.
"Democratic Spain" is the first thorough study of democratic
Spain's re-emergence on the international scene.Since the death of
General Franco in 1975, Spain has emerged from relative isolation
to play an active role in international affairs. Membership of the
European Union and Nato have been keys to Spain's new prominence,
although the country has also tried to build on its traditional
"special relationships" with Latin America and the Arab world.
Nuestro grupo describio un peptido ciclico proapoptotico que al unirse al dominio acido de los sustratos de CK2, interfiere la fosforilacion de esta, bloqueando su interaccion con el sustrato in vitro. Conduce a la regresion tumoral cuando es administrado directamente sobre tumores solidos. Este peptido, denominado P15-Tat, fue originalmente identificado y caracterizado examinando al azar peptidos ciclicos de 9 aminoacidos de longitud (nanopeptidos) en una biblioteca de fagos, utilizando como blanco un peptido sintetico de la oncoproteina E7 de HPV-16. El objetivo central de este trabajo consistio en estudiar y caracterizar los efectos del peptido P15-Tat sobre las celulas tumorales de carcinoma cervical humano HeLa y sobre la angiogenesis tumoral."
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