This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April, . 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M. MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C.

It is October of 1838 as a volunteer cavalry of Mormons gather in the woods. Ill-prepared for battle, they organize as best they can to face hundreds of mobbers who, with the governor's support, have besieged the people of DeWitt, Missouri. With supplies running low, members of the Church of Jesus Christ of Latter-day Saints are starving. But there is a bright light amid the darkness of despair: the cavalry's distinguished leader, Seymour Brunson. As Major Brunson leads his nervous soldiers into battle with the mobbers, he reassures them that God is on their side. Buoyed by courage and determination, the soldiers defend the DeWitt Saints-until they are all betrayed. But all is not lost as Brunson evades his captors and bravely helps the Saints find safety in Illinois. A Lively Stone is an engaging story of action, heroism, and love based on true events that chronicle the life of an important leader of the Church of Jesus Christ of Latter-day Saints.

This book examines contemporary English drama and its relation to the neoliberal consensus that has dominated British policy since 1979. The London stage has emerged as a key site in Britain's reckoning with neoliberalism. On one hand, many playwrights have denounced the acquisitive values of unfettered global capitalism; on the other, plays have more readily revealed themselves as products of the very market economy they critique, their production histories and formal innovations uncomfortably reproducing the strategies and practices of neoliberal labour markets. Stage Business and the Neoliberal Theatre of London thus arrives at a usefully ambivalent political position, one that praises the political power of the theatre - its potential as a form of resistance to the neoliberal rationality that rides roughshod over democratic values - while simultaneously attending to the institutional bondage that constrains it. For, of course, the theatre itself everywhere straddles the line of capitulating to the marketization of our cultural life.

Written by one of Italy's leading historians, this book analyses the context and legacy of Gaetano Filangieri's seven-volume 'Science of Legislation'. This study engages with the unique history of Enlightenment Naples, the intellectual traditions upon which Filangieri drew, and the powerful repercussions of the American Revolution in eighteenth-century Italy to re-draw the map of Enlightenment republicanism and the early history of human rights and their political economy.

This comprehensive and uniquely organized text is aimed at undergraduate and graduate level statistics courses in education, psychology, and other social sciences. A conceptual approach, built around common issues and problems rather than statistical techniques, allows students to understand the conceptual nature of statistical procedures and to focus more on cases and examples of analysis. Wherever possible, presentations contain explanations of the underlying reasons behind a technique. Importantly, this is one of the first statistics texts in the social sciences using R as the principal statistical package. Key features include the following.

• Conceptual Focus The focus throughout is more on conceptual understanding and attainment of statistical literacy and thinking than on learning a set of tools and procedures.
• Problems and Cases Chapters and sections open with examples of situations related to the forthcoming issues, and major sections ends with a case study. For example, after the section on describing relationships between variables, there is a worked case that demonstrates the analyses, presents computer output, and leads the student through an interpretation of that output.
• Continuity of Examples A master data set containing nearly all of the data used in the book s examples is introduced at the beginning of the text. This ensures continuity in the examples used across the text.
• Companion Website A companion website contains instructions on how to use R, SAS, and SPSS to solve the end-of-chapter exercises and offers additional exercises.
• Field Tested The manuscript has been field tested for three years at two leading institutions.

This is a fully revised new edition of this acclaimed practical manual.Indispensable for fieldworkers on projects or programs aiming to reduce the incidence of water-and-sanitation-related diseases, this book will also be useful for other relief and development workers, particularly those working in the fields of community development, health, and engineering.The authors describe a wide range of approaches to hygiene promotion that can be used in different settings. Central to these approaches is a commitment to working in collaboration with people and encouraging them to take more control over the factors that influence their lives. The authors stress the need for a form of hygiene promotion that fosters capacity-building rather than the provision of information alone.The opening chapter of the manual introduces the reader to the context of emergency relief and development projects and provides insights into current hygiene promotion theory. The main body of the text then goes on to consider the four phases of the project cycle--assessment, planning, implementation, and monitoring and evaluation--each of which is assigned a chapter for discussion. These chapters draw together the experience of hygiene promotion fieldworkers in many emergency and rehabilitation, water, sanitation, and hygiene program undertaken by CARE and other agencies. The annex comprises other useful material including a series of concise "how-to" guides, pictures for use or adaptation in the field, information about hygiene-related diseases and how to prevent them, and an annotated bibliography.

The purpose of this book is to provide the reader with a ready source of information regarding Ia antigens in several animal species.The significance role played by the gene products of I regions in cell-cell interactions has stimulated interest in the characterization of Ia antigens. Through the effort of several investigations much information about the functional and structural properties of Ia antigens has been accumulated in recent years.

The purpose of this book is to provide the reader with a ready source of information regarding Ia antigens in several animal species.The significance role played by the gene products of I regions in cell-cell interactions has stimulated interest in the characterization of Ia antigens. Through the effort of several investigations much information about the functional and structural properties of Ia antigens has been accumulated in recent years.

My First Book of Microbes is the ideal STEM book for children - it uses fascinating bite-size facts, clear and simple explanations, and attractive and absorbing illustrations to demystify the hidden world of microbes. You'll discover what they are, where they come from and what they do, as well as which ones are good and which can be harmful. Especially pertinent are the clear explanations about how viruses spread, the role of antibodies and the importance of vaccines - essential understanding for us all during this time of the COVID-19 pandemic; in fact, there's a whole spread dedicated to COVID-19. Packed with clever analogies that make understanding a difficult topic easy, this STEM title is perfect for young budding scientists with an active and enquiring mind and for people of any age who are interested in learning about the natural world and the human body. Sales points: Bestselling and award-winning illustrator and author duo of the bestselling My First Book of Quantum Physics, plus My First Book of Relativity and My First Book of the Cosmos Introduces children aged 8 and up to a complex area of science in a fun and entertaining way Adults are likely to enjoy the content and find that it increases their understanding Topical subject matter - viruses, including information about COVID-19, antibodies and vaccines Common Core: RI.6.1,2,3,4,5,6,7,8,9; W.6.1.1a,1b,1c,1d,2,2a,2b,2c,2d,2e,2f,4,5,6,7,8,9b; SL.6.1,1,1b,1c,1d,2,3,4,5,6; L.6.3,3a,3b,4,4a,4b,4c, 5a,5b,5c,6; GRL: W

The heroes travel to Absalom Station to warn the Pact Worlds government of a fast-approaching threat from beyond the stars! But before they are fully prepared, the titanic spacecraft arrives and shuts down the fabled Starstone Reactor, plunging the station into chaos. The heroes must find a way to bring the power back online, while rescuing citizens and dealing with Azlanti spies, angry outsiders, and confused spirits. Can they save the heart of the Pact Worlds and take the fight to the strange alien vessel? "The Starstone Blockade" is a Starfinder Roleplaying Game adventure for four 16th-level characters. This adventure continues The Devastation Ark Adventure Path, a three-part, monthly campaign in which the players stop the threat of an ancient alien civilization in Starfinder's first high-level adventures! This volume also includes an examination of the church of Eloritu-the god of history, magic, and secrets-as well as a selection of ghastly new aliens! Each monthly full-color softcover Starfinder Adventure Path volume contains a new installment of a series of interconnected science-fantasy quests that together create a fully developed plot of sweeping scale and epic challenges. Each 64-page volume of the Starfinder Adventure Path also contains in-depth articles that detail and expand the Starfinder campaign setting and provide new rules, a host of exciting new monsters and alien races, a new planet to explore and starship to pilot, and more!

The ever-expanding research on human cancer has resulted in numerous technical and conceptual advances during the last few years. Serological, structural, and biological char acterization of human melanoma constitutes one area of research that has received consid erable attention from researchers and clinicians and has generated new and exciting infor mation. In this volume, we have attempted to assemble work on topics that produced some of the most recent advances. We asked each author to describe and interpret his most cur rent research and, whenever possible, to compare and contrast it with work of other inves tigators in the field. We have been careful not to impose our viewpoints except in contri butions from our own laboratories, since we want to provide the reader with as many divergent and sometimes opposing viewpoints as feasible. Therefore, we have not been overly concerned with overlaps in some individual topics. We hope that this volume will provide the reader with a well-balanced overview of current problems and ideas in a par ticular area of cancer research. We wish to express our thanks to all contributors for their timely and very interesting manuscripts, and we sincerely hope that the reader will enjoy this volume and benefit as much from it as we did. R. A. Reisfeld S. Ferrone La Jolla ix Contents CHAPTER 1 Immunogenetics of Melanoma RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. Go, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Malignant melanoma is the focus of investigations which range from basic re search to clinical trials with conventional therapy and with biological response modifiers. The involvement of investigators with different backgrounds in combi nation with recent progress in biotechnology has facilitated the characterization of the antigenic profile of melanoma cells, the analysis of the structural and function al properties of melanoma-associated antigens, and the application of immuno diagnostic and immunotherapeutic approaches to melanoma. As a result, a large body of information about various aspects of melanoma has been rapidly accumu lated during the past few years. In organizing this book I aimed at providing a readily available source of infor mation on the current research in melanoma. To this end I invited investigators with active research programs to contribute chapters describing and discussing the significance of their most recent results. To facilitate the preparation of the manu scripts and to avoid duplicating other recently published books on melanoma, I discouraged the contributors from providing extensive reviews of the literature on the various topics. Although I made every effort to be as complete as possible in the selection of the contributors, while writing this preface I realized that I had overlooked at least three investigators whose work should have been included.

This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers."

In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April, . 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M. MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C.

This book examines contemporary English drama and its relation to the neoliberal consensus that has dominated British policy since 1979. The London stage has emerged as a key site in Britain's reckoning with neoliberalism. On one hand, many playwrights have denounced the acquisitive values of unfettered global capitalism; on the other, plays have more readily revealed themselves as products of the very market economy they critique, their production histories and formal innovations uncomfortably reproducing the strategies and practices of neoliberal labour markets. Stage Business and the Neoliberal Theatre of London thus arrives at a usefully ambivalent political position, one that praises the political power of the theatre - its potential as a form of resistance to the neoliberal rationality that rides roughshod over democratic values - while simultaneously attending to the institutional bondage that constrains it. For, of course, the theatre itself everywhere straddles the line of capitulating to the marketization of our cultural life.