Malignant lymphomas remain a fascinating research topic for clinicians as well as basic scientists. Rapidly increasing technical sophistication, ex panded knowledge and broader implications of new findings underline the need for a forum to integrate the latest developments in the multiple areas involved in the challenging study of lymphoid malignancies. This volume includes contributions of renowned experts and is based on a selection of papers presented at the Second International Conference on Malignant Lymphomas that was held in Lugano, Switzerland, in June 1984. Updated information is provided on various experimental fields including cell biolo gy, immunology, genetics and cell biochemistry. Particular attention has been given to special clinical entities such as the lymphomas associated with the Acquired Immune Deficiency Syndrome. Recent advances in the treat of Hodgkin's disease, ncin-Hodgkin's lymphomas and childhood lym ment phomas are highlighted with emphasis on growing experience with new therapeutic approaches including monoclonal antibodies and bone marrow transplantation. The contents of the volume reflect and translate numerous avenues of exploration. While there might be some unavoidable overlap, most appear essentially complementary. The intent of the Program Committee of the Second International Conference on Malignant Lymphomas was to promote further interactions between all those who are devoting major efforts to elucidate the nature of these diseases or their optimal therapy. This volume will hopefully amplify this objective. The Editors wish to thank the contributors for delivering the manuscripts on schedule."

Lymphomas classically manifest themselves in the lymph nodes but can also present in other bodily tissues or systems; the organ where exactly they present may make a very great difference to the strategy that should be adopted for their management. This topic has only recently been consistently addressed as an issue on its own, apart from the rest of the lymphomas, and this text is the first to apply modern systems of classification, diagnosis and management. This text is essential reading for hematologic oncologists and hematopathologists.

Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the rationale for choosing specific drugs and combinations. Textbook of Medical Oncology, 4th edition, is written by a highly acclaimed list of international authors and is a key source of reference for all working in the field of oncology.

Starting in 1986, the European School of Oncology has expanded its activities in postgraduate teaching, which consisted mainly of traditional disease-orientated courses, by promoting new educational initiatives. One of these is the cloister seminars, short meetings intended for highly qualified oncologists and dealing with specific, controversial aspects of clinical practice and research. Another is the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on developments and treatment in specific fields of oncology. This series of ESO Monographs was designed with the specific purpose of disseminating the results of the most interesting of the seminars and study groups, and providing concise and updated reviews of the subjects discussed. It was decided to keep the layout very simple in order to keep costs to a minimum and make the monographs available in the shortest possible time, thus overcoming a common problem in medical literature: that of the material being outdated even before publication. Umberto Veronesi Chairman, Scientific Committee European School of Oncology Table of Contents How to Read this Monograph F.CAvALLI ......... . 1 Experimental Strategies for Studying the Development of Breast Cancer with Special Reference to Steroid Hormones, Growth Factors and Oncogenes R.J.B. KING . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 5 . . .

Malignant lymphomas remain a fascinating research topic for clinicians as well as basic scientists. Rapidly increasing technical sophistication, ex panded knowledge and broader implications of new findings underline the need for a forum to integrate the latest developments in the multiple areas involved in the challenging study of lymphoid malignancies. This volume includes contributions of renowned experts and is based on a selection of papers presented at the Second International Conference on Malignant Lymphomas that was held in Lugano, Switzerland, in June 1984. Updated information is provided on various experimental fields including cell biolo gy, immunology, genetics and cell biochemistry. Particular attention has been given to special clinical entities such as the lymphomas associated with the Acquired Immune Deficiency Syndrome. Recent advances in the treat of Hodgkin's disease, ncin-Hodgkin's lymphomas and childhood lym ment phomas are highlighted with emphasis on growing experience with new therapeutic approaches including monoclonal antibodies and bone marrow transplantation. The contents of the volume reflect and translate numerous avenues of exploration. While there might be some unavoidable overlap, most appear essentially complementary. The intent of the Program Committee of the Second International Conference on Malignant Lymphomas was to promote further interactions between all those who are devoting major efforts to elucidate the nature of these diseases or their optimal therapy. This volume will hopefully amplify this objective. The Editors wish to thank the contributors for delivering the manuscripts on schedule.

H: SACK Lungentumoren sind die haufigste Krebstodesursache bei Mannern tiber 35 Jahren, die epidemiologischen Daten der letzten Jahre lassen erkennen, daB dies bald auch auf Frauen zutreffen wird. Zum Zeitpunkt der Diagnose hat das Bronchialkarzinom bei 70% der Patienten bereits Metastasen abgesiedelt, bei 22% in die regionalen Lymphknoten und bei 48% hamatogen. Das erkHirt, warum viele Patienten innerhalb des ersten Jahres nach Diagnosestellung versterben. Aber auch bei den Kranken mit einer klinisch lokalisierten Erkran- kung (17%) ist eine Oberlebenserwartun von 5 Jahren eher die Ausnahme als die Regel. Viele Hoffnungen wurden bei diesen Gegebenheiten auf die Friihdiagnose ge- setzt, urn den Tumor im loko-regional begrenzten Stadium der Operation zu- fUhren zu konnen, die fast allein als kurative BehandlungsmaBnahme anzuse- hen ist. Die Friihdiagnostik hat jedoch die in sie gesetzten Erwartungen nicht erftillen konnen. Feldstudien in den USA und der DDR haben eine Verbesse- rung der Oberlebensraten nicht erreichen konnen. Die Moglichkeiten der Friihdiagnose sind weiterhin beschrankt, Vorsorgeuntersuchungen fUr die Ge- samtbevolken, mg sind deshalb nicht empfehlenswert. Die folgenden Beitrage namhafter Forscher und Kliniker sollen den Stand des heute Moglichen in der Behandlung von Kranken mit Lungenkrebs diskutieren und Wege zur Verbesserung der Ergebnisse aufzeigen. Auch von den in kurati- ver Absicht radikal Operierten leben nach 5 Jahren nur rund 30%, nach 10 Jah- ren 15%. Die Operationsletalitat betragt je nach der GroBe des Eingriffs 4-11 %.

Lymphomas classically manifest themselves in the lymph nodes but can also present in other bodily tissues or systems; the organ where exactly they present may make a very great difference to the strategy that should be adopted for their management. This topic has only recently been consistently addressed as an issue on its own, apart from the rest of the lymphomas, and this text is the first to apply modern systems of classification, diagnosis and management. This text is essential reading for hematologic oncologists and hematopathologists.