The authors present their experience in more than seven years of dynamic computed tomography in clinical practice. Time density curves and characteristic examples in specific regions of interest enrich the presentation. Dynamic computed tomography makes an important contribu tion to the diagnosis and evaluation of a pathologic process: the demonstration of the dynamics of blood flow within the lesion and surrounding normal tissue. Since both the lesion itself and adjacent normal tissue demonstrate characteristic findings in each circulatory phase, the study provides a large amount of data on the flow of blood and contrast material which facilitate both recognition and diiferentation of a lesion. Late studies following administration of a contrast agent allow an estimate of the passage of the contrast medium to the inter stitium, which is of diagnostic importance. Chapters dealing with specific clinical entities also contain useful information on the most appropriate means of contrast agent administration (bolus injection or infusion) as well as a discussion of indications for the procedure. Dynamic computed tomography represents a significant advance over conventional computed tomography in some situations, and this signifies a major contri bution to the diagnostic capabilities of the clinical radiologist. The authors are to be commended for the fact that they have clearly defined the limits of dynamic computed tomography. I hope that the first English language edition, following the appea rance of the German version in 1983, will be well received."

Effective treatment of acute myocardial infarction remains one of the major issues in cardiology and internal medicine. The present monograph summarizes the relevant experimental data and the results of major clinical trials in the treatment of myocardial infarction. There are contributions of fundamental anatomical and physiological concepts of vascular occlusion and myocardial damage due to ischemia as well as discussions of therapeutic strategies involving thrombolytic agents, adjuvant drug therapy for limitation of myocardial damage, improvement in myocardial tolerance to ischemia and prevention of coronary reocclusion. In this regard, there is an extensive discussion of the role of coronary angioplasty and bypass surgery in the setting of acute myocardial infarction.