A little boy meets a stranded alien child and the two instantly strike up a fabulous friendship. They go to school, explore the neighborhood, and have lots of fun all day. However, when bedtime rolls around, the little boy must comfort his homesick new friend. This funny, heartwarming story proves that friends and family are the most important things in the universe . . . no matter who or where you are.

The central theme of this book is national land and infrastructure design in the age of the declining population and the recovery from the Great East Japan Earthquake in the affected regions in Japan. Based on the theory of spatial economics and evidence from Japanese history, the authors show that the growing economy with a population increase develops into a multi-cored and complex structure. In the population decline phase, however, such construction will be destabilized because of agglomeration economies in the central core. Then, a catastrophic shock that strikes may provoke the decline of the lower-rank-size provincial cities and their eventual disappearance if they compete only in lower prices of staple products. Not only is the practice bad for the residents; it also leads to lower national welfare resulting from the loss of diversity and overcrowded big cities. The authors argue that small local towns can recover and will be sustained if they will endeavor in innovative production by making good use of local natural resources and social capital. Under the ongoing declining population in Japan, an undesirable concentration in Tokyo will proceed further with increasing social cost and risk. The recent novel coronavirus pandemic has highlighted that concern.

Arsenic is likely the most talked-about metalloid in the modern world because of its toxic effects on both animal and plants. Further, arsenic pollution is now producing negative impacts on food security, especially in many south Asian countries. Since plants are a major food source, their adaptation to As-rich environments is essential, as is being informed about recent findings on multifarious aspects of the mechanisms of arsenic toxicity and tolerance in plants. Although numerous research works and review articles have been published in journals, annual reviews and as book chapters, to date there has been no comprehensive book on this topic. This book contains 19 informative chapters on arsenic chemistry, plant uptake, toxicity and tolerance mechanisms, as well as approaches to mitigation. Readers will be introduced to the latest findings on plant responses to arsenic toxicity, various tolerance mechanisms, and remediation techniques. As such, the book offers a timely and valuable resource for a broad audience, including plant scientists, soil scientists, environmental scientists, agronomists, botanists and molecular biologists.

Glutathione ( -glutamyl-cysteinyl-glycine) is a ubiquitously distributed sulfurcontaining antioxidant molecule that plays key roles in the regulation of plant growth, development, and abiotic and biotic stress tolerance. It is one of the most powerful low-molecular-weight thiols, which rapidly accumulates in plant cells under stress. Recent in-depth studies on glutathione homeostasis (biosynthesis, degradation, compartmentalization, transport, and redox turnover) and the roles of glutathione in cell proliferation and environmental stress tolerance have provided new insights for plant biologists to conduct research aimed at deciphering the mechanisms associated with glutathione-mediated plant growth and stress responses, as well as to develop stress-tolerant crop plants. Glutathione has also been suggested to be a potential regulator of epigenetic modifications, playing important roles in the regulation of genes involved in the responses of plants to changing environments. The dynamic relationship between reduced glutathione (GSH) and reactive oxygen species (ROS) has been well documented, and glutathione has been shown to participate in several cell signaling and metabolic processes, involving the synthesis of protein, the transport of amino acids, DNA repair, the control of cell division, and programmed cell death. Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels. Any fluctuations in cellular GSH and oxidized glutathione (GSSG) levels have profound effects on plant growth and development, as glutathione is associated with the regulation of the cell cycle, redox signaling, enzymatic activities, defense gene expression, systemic acquired resistance, xenobiotic detoxification, and biological nitrogen fixation. Being a major constituent of the glyoxalase system and ascorbate-glutathione cycle, GSH helps to control multiple abiotic and biotic stress signaling pathways through the regulation of ROS and methylglyoxal (MG) levels. In addition, glutathione metabolism has the potential to be genetically or biochemically manipulated to develop stress-tolerant and nutritionally improved crop plants. Although significant progress has been made in investigating the multiple roles of glutathione in abiotic and biotic stress tolerance, many aspects of glutathione-mediated stress responses require additional research. The main objective of this volume is to explore the diverse roles of glutathione in plants by providing basic, comprehensive, and in-depth molecular information for advanced students, scholars, teachers, and scientists interested in or already engaged in research that involves glutathione. Finally, this book will be a valuable resource for future glutathione-related research and can be considered as a textbook for graduate students and as a reference book for frontline researchers working on glutathione metabolism in relation to plant growth, development, stress responses, and stress tolerance.

This book provides comprehensive coverage of the new wide-bandgap semiconductor gallium oxide (Ga2O3). Ga2O3 has been attracting much attention due to its excellent materials properties. It features an extremely large bandgap of greater than 4.5 eV and availability of large-size, high-quality native substrates produced from melt-grown bulk single crystals. Ga2O3 is thus a rising star among ultra-wide-bandgap semiconductors and represents a key emerging research field for the worldwide semiconductor community. Expert chapters cover physical properties, synthesis, and state-of-the-art applications, including materials properties, growth techniques of melt-grown bulk single crystals and epitaxial thin films, and many types of devices. The book is an essential resource for academic and industry readers who have an interest in, or plan to start, a new R&D project related to Ga2O3.

In accordance with the developments in computation, theoretical studies on numerical schemes are now fruitful and highly needed. In 1991 an article on the finite element method applied to evolutionary problems was published. Following the method, basically this book studies various schemes from operator theoretical points of view. Many parts are devoted to the finite element method, but other schemes and problems (charge simulation method, domain decomposition method, nonlinear problems, and so forth) are also discussed, motivated by the observation that practically useful schemes have fine mathematical structures and the converses are also true. This book has the following chapters: 1. Boundary Value Problems and FEM. 2. Semigroup Theory and FEM. 3. Evolution Equations and FEM. 4. Other Methods in Time Discretization. 5. Other Methods in Space Discretization. 6. Nonlinear Problems. 7. Domain Decomposition Method.

Ascorbic acid (AsA), vitamin C, is one of the most abundant water-soluble antioxidant in plants and animals. In plants AsA serves as a major redox buffer and regulates various physiological processes controlling growth, development, and stress tolerance. Recent studies on AsA homeostasis have broadened our understanding of these physiological events. At the mechanistic level, AsA has been shown to participate in numerous metabolic and cell signaling processes, and the dynamic relationship between AsA and reactive oxygen species (ROS) has been well documented. Being a major component of the ascorbate-glutathione (AsA-GSH) cycle, AsA helps to modulate oxidative stress in plants by controlling ROS detoxification alone and in co-operation with glutathione. In contrast to the single pathway responsible for AsA biosynthesis in animals, plants utilize multiple pathways to synthesize AsA, perhaps reflecting the importance of this molecule to plant health. Any fluctuations, increases or decreases, in cellular AsA levels can have profound effects on plant growth and development, as AsA is associated with the regulation of the cell cycle, redox signaling, enzyme function and defense gene expression. Although there has been significant progress made investigating the multiple roles AsA plays in stress tolerance, many aspects of AsA-mediated physiological responses require additional research if AsA metabolism is to be manipulated to enhance stress-tolerance. This book summarizes the roles of AsA that are directly or indirectly involved in the metabolic processes and physiological functions of plants. Key topics include AsA biosynthesis and metabolism, compartmentation and transport, AsA-mediated ROS detoxification, as well as AsA signaling functions in plant growth, development and responses to environmental stresses. The main objective of this volume is therefore to supply comprehensive and up-to-date information for students, scholars and scientists interested in or currently engaged in AsA research.

This book addresses several important aspects of complex automated negotiations and introduces a number of modern approaches for facilitating agents to conduct complex negotiations. It demonstrates that autonomous negotiation is one of the most important areas in the field of autonomous agents and multi-agent systems. Further, it presents complex automated negotiation scenarios that involve negotiation encounters that may have, for instance, a large number of agents, a large number of issues with strong interdependencies and/or real-time constraints.

This book provides a description of advanced multi-agent and artificial intelligence technologies for the modeling and simulation of complex systems, as well as an overview of the latest scientific efforts in this field. A complex system features a large number of interacting components, whose aggregate activities are nonlinear and self-organized. A multi-agent system is a group or society of agents which interact with others cooperatively and/or competitively in order to reach their individual or common goals. Multi-agent systems are suitable for modeling and simulation of complex systems, which is difficult to accomplish using traditional computational approaches.

With the globalization of economic activity bringing about the expansion of markets and deepening of economic interdependency beyond state-borders, a new political challenge arises: how to effectively integrate the interdependent economies into a harmonious unity through the creation of new super-state institutions? This book applies a spatial economics perspective to the understanding of the recent dynamism of the global economy, with particular focus on East Asia. In addition, it examines the prospects of regional integration in East Asia.

This book describes the state of the lay participation system in criminal justice, saiban-in seido, in Japanese society. Starting with descriptions of the outlines of lay participation in the Japanese criminal justice system, the book deals with the questions of what the lay participants think about the system after their participation, how the general public evaluate the system, whether the introduction of lay participation has promoted trust in the justice system in Japan, and the foci of Japanese society's interest in the lay participation system. To answer these questions, the author utilizes data obtained from social surveys of actual participants and of the general public. The book also explores the results of quantitative text analyses of newspaper articles. With those data, the author describes how Japanese society evaluates the implementation of the system and discusses whether the system promotes democratic values in Japan.

Chirality and stereogenicity are closely related concepts and their differentiation and description is still a challenge in chemoinformatics. In his 2015 book, Fujita developed a new stereoisogram approach that provided theoretical framework for mathematical aspects of modern stereochemistry. This new edition includes a new chapter on Computer-Oriented Representations developed by the author based on Groups, Algorithms, Programming (GAP) system.

This book is the outcome of the international symposium on 'Economic Integration in Asia and India' held in Tokyo, Japan, on Decemeber 8, 2005.
In the flow of globalization in the world economies, the regional economic integrations which have been progressing institutionally in the EU and Americas are now substantially under way among countries in Asia, including Japan, Korea, China and the ASEAN countries. India has also taken steps on the passage towards economic integration. India's full-scale participation in the Asian market will affect other East Asian countries, which in turn will also have manifold influences on India. This book aims to trigger a wider examination of Asian economic integration.

This book focuses on all aspects of complex automated negotiations, which are studied in the field of autonomous agents and multi-agent systems. This book consists of two parts. I: Agent-Based Complex Automated Negotiations and II: Automated Negotiation Agents Competition. The chapters in Part I are extended versions of papers presented at the 2012 international workshop on Agent-Based Complex Automated Negotiation (ACAN), after peer reviews by three Program Committee members. Part II examines in detail ANAC 2012 (The Third Automated Negotiating Agents Competition), in which automated agents that have different negotiation strategies and are implemented by different developers are automatically negotiated in the several negotiation domains. ANAC is an international competition in which automated negotiation strategies, submitted by a number of universities and research institutes across the world, are evaluated in tournament style. The purpose of the competition is to steer the research in the area of bilateral multi-issue, closed negotiation. This book also includes the rules, results, agents and domain descriptions for ANAC 2011 as submitted by the organizers and finalists.

This book focuses on the evolutionary and developmental origins of the social mind. Written by leading scientists in the field, the book brings together the currently segregated views on social cognition in the two fields.

Mathematics education in contrast has a variable and culturally based character, and this is certainly true of educational organization and practice. Educational research is both an applied social science and a multidisciplinary domain of theoretical scholarship.

Among organizations devoted to mathematics education, The International Commission on Mathematical Instruction (ICMI) is distinctive because of its close ties to the mathematics community. The great challenges now facing mathematics education around the world demand a deeper and more sensitive involvement of disciplinary mathematicians than we now have, both in the work of educational improvements and in research on the nature of teaching and learning.

This book constitutes the Proceedings of the Ninth International Conference on Mathematical Education (ICME9), which was held in Tokyo/Makuhari Japan, in July and August 2000. ICME9 brought together experts from 70 countries, working to understand the challenges of mathematics education including boundary crossing and collaboration, such as the need to reconcile language, epistemology, norms of evidence and, in general, all of the intellectual and attitudinal challenges that face multidisciplinary research and development.

The program for ICME9 reflects a truly international character and includes four distinguished regular lectures, 52 lectures, four national presentations and reports from current ICMI Studies and ICMI Affiliated Study Groups. The goal of the meeting was to offer presentations and learning on various aspects of mathematics educations; its research, experiences, materials, and information with special emphasis on achievements and trends thatarose in mathematics education during the period of 1996-2000, and that would make important contributions to mathematics education in the new century.

In conventional color photography, spectral sensitizers cooperate with silver halide as acceptors of light during the exposure process, color developers reduce silver halide grains during the developing process, and finally the resulting oxidized developers react with couplers to form imaging dyes. Instant color photography gives us an alternative way of realizing excellent color reproduction, in which dyes changing their diffusibility play an important role. The aim of this book is to provide researchers and graduate students with a perspective on how such organic compounds work in color photography and how seemingly miraculous techniques based on organic chemistry lead to color images of high quality. The readers will acquire the philosophy and learn from hints on how to develop functionalized organic compounds.

This book aims to clarify the present situation of the relations between small island countries and territories on the one hand and the great powers, mainland areas, and mega-islands on the other, and explores how small island countries and territories preserve and build their identity under globalization. This book is divided into five parts. The first part presents papers on issues that are related to Okinawa: the American military presence, the formation of a global human network, and the history of and language revitalization in Okinawa. The second part includes papers on security in East Asia and the Pacific Region: the history of and present issues in international relations within the South and East China Sea areas. The third part presents papers on economic issues and social developments on small islands. The fourth part deals with ocean policies and marine resource management in the Pacific Region by the United States, Australia, and Japan. Finally, the fifth part presents papers on the revitalization of three indigenous languages. All the chapters of the book are based on the achievements of the research project "Towards New Island Studies: The Ryukyus as an academic node between East Asia and Oceania" conducted by the International Institute for Okinawan Studies at the University of the Ryukyus. This 5-year project was funded by the Japanese Ministry of Education, Culture, Sports, Science and Technology and aimed to contribute academically to the creation of sustainable and self-determinable societies in small island regions. This work will be extremely useful and informative for readers in small island countries and territories and for researchers who are interested in small island issues to understand the current situation and who wish to consider effectual and feasible solutions.

Engineers are always interested in the worst-case scenario. One of the most important and challenging missions of structural engineers may be to narrow the range of unexpected incidents in building structural design. Redundancy, robustness and resilience play an important role in such circumstances. "Improving the Earthquake Resilience of Buildings: The worst case approach" discusses the importance of worst-scenario approach for improved earthquake resilience of buildings and nuclear reactor facilities.

"Improving the Earthquake Resilience of Buildings: The worst case approach" consists of two parts. The first part deals with the characterization and modeling of worst or critical ground motions on inelastic structures and the related worst-case scenario in the structural design of ordinary simple building structures. The second part of the book focuses on investigating the worst-case scenario for passively controlled and base-isolated buildings. This allows for detailed consideration of a range of topics including:

A consideration of damage of building structures in the critical excitation method for improved building-earthquake resilience,

A consideration of uncertainties of structural parameters in structural control and base-isolation for improved building-earthquake resilience, and

New insights in structural design of super high-rise buildings under long-period ground motions.

"Improving the Earthquake Resilience of Buildings: The worst case approach" is a valuable resource for researchers and engineers interested in learning and applying the worst-case scenario approach in the seismic-resistant design for more resilient structures.

This book addresses the use of MEMS and micromachined devices for the investigation of nanoscience and technology, as well as biotechnology. Such micromachined tools for nanotechnology can enhance the sensitivity, spatial resolution, dexterity, selectivity, and parallel processing capability in measuring and manipulating nano-objects. The book covers state-of-the-art MEMS and NEMS devices for DNA molecular handling and analysis, cell handling and culture on a chip, chemical lab-on-a-chip, multi-probes for vacuum tunneling microscopy and AFM, and characterization of quantum semiconductor structures. Readers will gain deep insight into such developments and students will learn about the emerging field of MEMS and nanotechnology.