Most organic reactions have long been carried out in organic solvents without concern for their real necessity, reaction efficiency, and pollution problems. Very recently, we have found that most organic reactions can be carried out in the absence of a solvent, namely, in the solid state. In many cases, the solid-state reaction proceeds more easily and efficiently, and even more selectively than solution reaction. This shows that molecules move easily and selectively in the solid state. This finding changed the classical idea which suggests "molecules do not move and reactions do not occur in the solid state," and opened up a new research field for the study molecular dynamics in the solid state. The organic solid state reactions have many possibilities to be developed. For example, enantioselective reactions can easily be accomplished by carrying out the reaction in an inclusion complex crystal with an optically active host compound.

Catalytic reactions also proceed in the solid state. Moreover, the solid-state reactions are more economical and ecologically sound. In the future, pollution-free synthetic procedures in the solid state will become increasingly important, not only in chemical industries but also in university laboratories.

In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called "optical resolution" or simply "resolution." Nowadays, the descriptions "enantiomer resolution" or "enantiomer separation" are also commonly used. Accordingly, "Enantiomer Separation" is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Most organic reactions have long been carried out in organic solvents without concern for their real necessity, reaction efficiency, and pollution problems. Very recently, we have found that most organic reactions can be carried out in the absence of a solvent, namely, in the solid state. In many cases, the solid-state reaction proceeds more easily and efficiently, and even more selectively than solution reaction. This shows that molecules move easily and selectively in the solid state. This finding changed the classical idea which suggests "molecules do not move and reactions do not occur in the solid state," and opened up a new research field for the study molecular dynamics in the solid state. The organic solid state reactions have many possibilities to be developed. For example, enantioselective reactions can easily be accomplished by carrying out the reaction in an inclusion complex crystal with an optically active host compound.

Catalytic reactions also proceed in the solid state. Moreover, the solid-state reactions are more economical and ecologically sound. In the future, pollution-free synthetic procedures in the solid state will become increasingly important, not only in chemical industries but also in university laboratories.

In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called "optical resolution" or simply "resolution." Nowadays, the descriptions "enantiomer resolution" or "enantiomer separation" are also commonly used. Accordingly, "Enantiomer Separation" is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Most organic reactions have long been carried out in organic solvents without concern for their real necessity, reaction efficiency, and pollution problems. Very recently, we have found that most organic reactions can be carried out in the absence of a solvent, namely, in the solid state. In many cases, the solid-state reaction proceeds more easily and efficiently, and even more selectively than solution reaction. This shows that molecules move easily and selectively in the solid state. This finding changed the classical idea which suggests "molecules do not move and reactions do not occur in the solid state," and opened up a new research field for the study molecular dynamics in the solid state. The organic solid state reactions have many possibilities to be developed. For example, enantioselective reactions can easily be accomplished by carrying out the reaction in an inclusion complex crystal with an optically active host compound.

Catalytic reactions also proceed in the solid state. Moreover, the solid-state reactions are more economical and ecologically sound. In the future, pollution-free synthetic procedures in the solid state will become increasingly important, not only in chemical industries but also in university laboratories.