In spite of important advances in asymmetric synthesis, chiral
compounds cannot all be obtained in a pure state by asymmetric
synthesis. As a result, enantiomer separation remains an important
technique for obtaining optically active materials. Although
asymmetric synthesis is a once-only procedure, an enantiomer
separation process can be repeated until the optically pure sample
is obtained. This book discusses several new enantiomer separation
methods using modern techniques developed by experts in the field.
These methods consist mainly of the following three types: 1)
Enantiomer separation by inclusion complexation with a chiral host
compound 2) Enantiomer separation using biological methods 3)
Enantiomer separation by HPLC chromatography using a column
containing a chiral stationary phase. Separation of a racemic
compound has been called "optical resolution" or simply
"resolution." Nowadays, the descriptions "enantiomer resolution" or
"enantiomer separation" are also commonly used. Accordingly,
"Enantiomer Separation" is used in the title of this book. The
editor and all chapter contributors hope that this book is helpful
for scientists and engineers working in this field.
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