Apoptosis is a fascinating concept for the basic scientist. This is not only because of the multifaceted variety of proposed and discovered mechanisms, but because apoptosis represents a fundamental pathway for cell renewal. The study of apoptosis has resulted in an array of discoveries on signal transduc tion and downstream effects that have facilitated and advanced many fields in biology, including research on cancer and other diseases. Thus, the apoptotic process can be viewed as the largest effort of the scientific community to understand how cells work and tissues assemble or remodel. The most direct consequence of this accumulated knowledge is a greater understanding of disease and pathological mechanisms. The end result of these efforts will be significant contributions to health and the adoption of new, never anticipated, therapeutic approaches. This book represents the summation of considerable effort from a significant group of contributors from all over the world as well as from its editors. In this fashion, many viewpoints have been collected and SUbjected to thorough academic discussion. The concepts contained in this medically important volume will stimulate and renew the ideas of scientists and indeed, will generate additional work to advance biological knowledge even further. The emphasis of this volume cements what has been established, adds what has not been explored fully, and creates a fertile ground for further hypotheses that will lead to a more complete understanding of the apoptotic process."

This book is concernced with the process of cell death in human cells by programmed cell death or apoptosis, and the modulation of this process by drugs. This is a new field of study and this volume represents the first comprehensive treatment of this subject matter. Its focus is on human biology and medicine. Apoptosis is a very prevalent type of cell death with importance in human diseases such as cancer, Alzheimer's disease and autoimmune disorders. The book combines the expertise of leading scientists and writers from fields as diverse as neurosciences, immunology, pathology and cancer research. There is detailed analysis of the molecular and cellular aspects of apoptosis including the specific genes and molecules involved in the regulation of this special form of programmed cell death. Scientists, clinicians and researchers involved in studies of human biology and medicine will find this book an excellent resource.

This book assesses the causes for, and the implications of, the escalating lethality of terrorism. This is then placed in the context of the growing opportunities for nuclear proliferation arising from the collapse of the Soviet Union. The book concludes that the organizational and psychological pressures within terrorist groups and the changing nature of political violence, combined with the heightened danger of nuclear non-proliferation, have made mass-destructive terrorism the greatest non-traditional threat to intellectual security in the world today.

Yukichi Fukuzawa rose from low samurai origins to become one of the finest intellectuals and social thinkers of modern Japan. Through his best-selling works, he helped transform an isolated feudal nation into a full-fledged international force.

In "Outline of a Theory of Civilization," the author's most sustained philosophical text, Fukuzawa translates and adapts a range of Western works for a Japanese audience, establishing the social, cultural, and political avenues through which Japan could connect with other countries. Echoing the ideas of Western contemporaries such as Ralph Waldo Emerson and Walt Whitman, Fukuzawa encouraged a grassroots elevation of the individual and national spirit, as well as free initiative in the private domain. Fukuzawa's bold project articulated thoughts that, for him, bolstered the material evidence of Western civilization. He argued that the essential difference separating Western countries from Japan and Asia was the extent to which citizens acted like free and responsible individuals.

This careful new translation, accompanied by a comprehensive critical introduction, highlights the truly transnational aspects of "Outline of a Theory of Civilization" and its status as a foundational text of modern Japanese civilization. Approaching Fukuzawa's progressive thought with a fresh eye, these scholars elucidate the monumental and peerless quality of his work.

Hayden Lowe may or may not have killed a man out west. No one seems to know why he's back in River Town, though his friend, Lillian Conley, is keeping a private journal full of clues. Will Captain JD Dawson lose his beloved sternwheeler, the Miss Jayne Marie, in a winner-takes-all bet? Julia Hubbard has a secret project, Andrew Wilson is plotting on the dusty streets of River Town, and what about that strange Dame Roxalana? There is more to Roxie than anyone is willing to say. The men in the coal mines around River Town seem to be developing a mysterious condition that no one can explain, yet everyone is whispering about it. Before all is said and done, each of these characters will intersect in unexpected ways. The resolutions are as suspenseful as they are satisfying. River Town is a collection of short stories set in 1890s West Virginia. The combined work of six different authors, the tales range from adventure to romance, from intrigue to fantasy. Each story stands alone, yet together they take readers to a time along the Kanawha River just after the Civil War when families were still struggling to recover and as the railroad was first making its way through the mountains. The river was the center of everything.

Will the 21st century see terrorist fingers on the nuclear trigger? How likely is it terrorists will obtain weapons of mass destruction? What factors would determine their decision to use them? In this text the author assesses the causes for, and implications of, the escalating lethality of terrorism. The growing opportunities for nuclear proliferation, primarily arising from the collapse of the Soviet Union are explained. The book concludes that the organizational and psychological pressures within terrorist groups and the changing nature of political violence combined with the heightened danger of nuclear micro proliferation have made mass destructive terrorism the greatest non traditional threat to international security in the world today.

Will the twenty-first century see terrorist fingers on the nuclear trigger? How likely is it terrorists will obtain weapons of mass destruction? What factors would determine their decision to use them? Gavin Cameron assesses the causes for, and implications of, the escalating lethality of terrorism. The growing opportunities for nuclear proliferation, primarily arising from the collapse of the Soviet Union are explained. The book concludes that the organisational and psychological pressures within terrorist groups and the changing nature of political violence combined with the heightened danger of nuclear micro-proliferation have made mass-destructive terrorism the greatest non-traditional threat to international security in the world today.

Originally published in 1939, this book contains an assessment of the historical evidence provided by ancient Babylonian cuneiform tablets. The text is accompanied by a number of photographs of the tablets, as well as of important archaeological sites and Babylonian artefacts. Chiera's enthusiasm for his subject is clear, as the text is accessibly written and contains many Babylonian legends and assesses their relationship to biblical texts. This book will be of value to anyone with an interest in Assyriology and the ancient Middle East.

It has been known for over a century that there is an afferent (body-to-brain) component to the visceral-autonomic nervous system. Despite the fundamental importance of bodily afferent information - sometimes called interoception - to central nervous system control of visceral organ function, emotional-motivational processes, and dysfunctino of these processes, including psychosomatic disorders, its role did not receive much attention until quite recently. This is the first comprehensive review of this topic and it covers both neurobiological and psychobiological aspects. The author first defines the issues and gives an historical background starting with the James-Lange theory of emotion, and addresses learning and motivation, roots in Pavlovian conditioning research, and operant conditioning of visceral function. In the second section he reviews recent scientific findings in the neural basis of visceral perception and studies in cardiovascular-respiratory and alimentary interoception. Finally, he discusses several related areas of research and theory including drug state issues, interoception and psychiatric disorders, and bodily consciousness, and suggests directions for future investigation.

This unique history of Japanese armed martial arts-the only comprehensive treatment of the subject in English-focuses on traditions of swordsmanship and archery from ancient times to the present. G. Cameron Hurst III provides an overview of martial arts in Japanese history and culture, then closely examines the transformation of these fighting skills into sports. He discusses the influence of the Western athletic tradition on the armed martial arts as well as the ways the martial arts have remained distinctly Japanese. During the Tokugawa era (1600-1867), swordsmanship and archery developed from fighting systems into martial arts, transformed by the powerful social forces of peace, urbanization, literacy, and professionalized instruction in art forms. Hurst investigates the changes that occurred as military skills that were no longer necessary took on new purposes: physical fitness, spiritual composure, character development, and sport. He also considers Western misperceptions of Japanese traditional martial arts and argues that, contrary to common views in the West, Zen Buddhism is associated with the martial arts in only a limited way. The author concludes by exploring the modern organization, teaching, ritual, and philosophy of archery and swordsmanship; relating these martial arts to other art forms and placing them in the broader context of Japanese culture.