The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Although the field of deliberative civic engagement is growing rapidly around the world, our knowledge and understanding of its practice and impacts remain highly fragmented. Democracy in Motion represents the first comprehensive attempt to assess the practice and impact of deliberative civic engagement. Organized in a series of chapters that address the big questions of deliberative civic engagement, it uses theory, research, and practice from around the world to explore what we know about, how we know it, and what remains to be understood. More than a simple summary of research, the book is designed to be accessible and useful to a wide variety of audiences, from scholars and practitioners working in numerous disciplines and fields, to public officials, activists, and average citizens who are seeking to utilize deliberative civic engagement in their communities. The book significantly enhances current scholarship, serving as a guide to existing research and identifying useful future research. It also has promise for enhancing practice, for example by helping practitioners, public officials, and others better think through and articulate issues of design and outcomes, thus enabling them to garner more support for public deliberation activities. In addition, by identifying what remains to be learned about public deliberation, practitioners and public officials may be inspired to connect with scholars to conduct research and evaluations of their efforts.

INVITATION TO COMPUTER SCIENCE, 6E, International Edition is a well-respected text that provides an overview of the computer science field. Using a flexible, non-language specific model, INVITATION TO COMPUTER SCIENCE, 6E, International Edition offers a solid foundation for the first course in a Computer Science curriculum. INVITATION TO COMPUTER SCIENCE, 6E, International Edition maintains its bestselling, algorithm-driven approach and includes expanded chapter exercises and practice problems, as well as new boxes dedicated to mobile applications and current issues throughout. Online language modules are available in C++, Java, Python, C#, and Ada, allowing the option of incorporating a programming language to expand concepts from the text. INVITATION TO COMPUTER SCIENCE, 6E, International Edition offers an optional CourseMate with study tools such as flashcards, quizzing, and games. CourseMate Activities speak to and engage students while developing abstract thinking and problem solving skills. Also available with INVITATION TO COMPUTER SCIENCE, 6E, International Edition, an optional Lab Manual containing 20 laboratory projects that map directly to the main text. The Lab Manual and accompanying software provide both visual and hands-on activities, allowing students to experience the fundamentals of computer science.

The creation of the Canadian Light Source (CLS) in Saskatoon, which began operation in 2004, was the largest science project in Canada in the last fifty years. The multi-beam facility operates more than five thousand hours per year and has more than one thousand Canadian and international users from a wide range of science, medical, and engineering disciplines. This book describes the decades of intense research from many scientists to justify this project and the resulting outstanding research covering many areas of the physical, biological, medical, and agricultural sciences. With personal accounts and frank narration, this book describes the long history leading to the CLS, beginning in Saskatoon in the 1930s. The core of the book highlights the remarkable and unselfish collaboration and cooperation of a few hundred people from Canadian and international universities, governments, and industry, showcasing how the Canadian Light Source represents pure and applied research at its finest.

A twisted, wildly imaginative tale of one man's mysterious illness and his journey through a dystopian hospital system. When Yang Wei travels to C City for work, he expects nothing more than a standard business trip. A break from his day-to-day routine, a good paycheck, a nice hotel-nothing too extravagant, of course. No fuss, but all the amenities. But this is where his problems begin. A complimentary bottle of mineral water from the hotel minibar results in sudden and debilitating stomach pain, followed by unconsciousness. When he wakes three days later, things don't improve; they get worse. With no explanation, the hotel forcibly sends him to a hospital for examination. There, he receives no diagnosis, no discharge date...just a diligent guide to the labyrinthine medical system he's now circulating through. Armed with nothing but his own confusion, Yang Wei travels deeper into the inner workings of the hospital and the secrets it's hiding from the patients. As he seeks escape and answers, one man's illness takes him on a quest through a corrupt system and his own troubled mind.

Since the Founding, America’s faith in a democratic republic has depended on citizens who could be trusted to be communicators. Vigorous talk about equality, rights, and collaboration fueled the revolution, the Declaration of Independence, and the Constitution with its amendments. In a republic, the people set the terms for their lives not individually, but in community. The genius of keeping it alive exists in how everyday citizens talk and listen, write and read, for a common good. Dialogue and deliberation—rather than an accumulation of individual preferences—sustains a republic, yet a diminished and scarred institution of journalism jeopardizes citizens’ access to shared and truthful information. A disturbing “what’s in it for me?” attitude has taken over many citizens, and a creeping, autocratic sense of dismissive accusation too often characterizes the political style of elected officials.The basic fuel for democracy is the willingness of informed citizens to take each other seriously as they talk about political choices. Once we begin to clam up, build walls, and dismiss each other, we unravel the threads tying us to the Founders’ vision of a republic. A free press and free speech become meaningless if not supported by sustained listening to multiple positions. There are those who profit by dividing citizens into two camps: a comfortable “us” versus a scary “them.” They make their case with accusations and often with lies. They warp the very meaning of communication, hoping citizens never truly discover each other’s humanity. Democracy’s News discusses today’s problems of public communication in the context of history, law, and interpersonal life. News should not be something to dread, mistrust, or shun. Aided by reliable, factual journalism, citizens can develop a community-based knowledge to cope with social issues great and small. They come to treat neighbors and strangers as more than stereotypes or opponents. They become collaborators with whom to identify and sustain a working republic where news, citizenship, and public discourse merge.

"Struggle for a Better South" dispels the notion that all whites in the South stood united against social change in the 1960s. Gregg Michel's compelling study of the Southern Student Organizing Committee (SSOC), the leading progressive organization created by young white activists in the South during that tumultuous decade, fills a crucial gap in the literature about New Left activism. Michel shows that the SSOC was the only activist group of the era that worked to cultivate white support for the social movement. The SSOC's members gave themselves the delicate task of reconciling their love for the South and its history--warts and all--with their modern-day commitment to equality and justice for all people.

In the follow-up to the visionary Hospital, Yang Wei discovers that there’s more to the mysterious hospital than meets the eye—and none of it is as it seems. Yang Wei wakes to find himself still a patient at the hospital. Somehow, he’s aged decades overnight and is confined to the geriatric ward on a massive Hospital ship as it floats along a bloodred sea full of unsightly things. But human remains and sea nymphs are perhaps nothing compared to the goings-on belowdecks. The doctors are nowhere to be found, replaced by a procession of medical robots from whom, of course, no information can be gleaned. So Yang Wei, along with a small group of patients—all just as aged as he is—venture out to explore the uncharted depths of the ship and the answers that are surely hidden within. As they delve deeper into both the ship and why they’re on it, every uncovered secret comes with its own questions. The only thing Yang Wei can be sure of is that the more he learns, the less he understands…and the less he truly wants to know.

Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition). Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system - poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

The 9th Italian Conference on Theoretical Computer Science (ICTCS 2005)was held at the Certosa di Pontignano, Siena, Italy, on October 12 14 2005. The Certosa di Pontignano is the conference center of the University of Siena; it is located 8 km away from the town and it is in the Chianti region. The Certosa is a place full of history (founded in the 15th century, it was set on ?re a century later and reconstructed) and of valuable artworks, like frescoes of the Scuola Senese. Previous conferences took place in Pisa (1972), Mantova (1974 and 1989), L Aquila(1992), Ravello(1995), Prato(1998), Turin(2001)andBertinoro(2003). Theconferenceaimsatbringingtogethercomputerscientists, especiallyyoung researchers, to foster cooperation, exchange of ideas and results. Great e?orts have been made to attract researchers from all over the world. The main t- ics of the conference cover all the ?elds of theoretical computer science and include analysis and design of algorithms, computability, computational c- plexity, cryptography, formal languages and automata, foundations of progr- ming languages and program analysis, foundations of arti?cial intelligence and knowledge representation, foundations of web programming, natural computing paradigms (quantum computing, bioinformatics), parallel and distributed c- putation, program speci?cation and veri?cation, term rewriting, theory of c- currency, theory of data bases, theory of logical design and layout, type theory, security, and symbolic and algebraic computation."

Gain a contemporary overview of today's computer science with the best-selling INVITATION TO COMPUTER SCIENCE, 8E. This flexible, non-language-specific book uses an algorithm-centered approach that's ideal for your first introduction to computer science. Measurable learning objectives and a clear hierarchy help introduce algorithms, hardware, virtual machines, software development, applications, and social issues. Exercises, practice problems, and feature boxes emphasize real-life context as well as the latest material on privacy, drones, cloud computing, and net neutrality. Optional online language modules for C++, Java, Python, C#, and Ada let you learn a programming language. MindTap is available with online study tools, a digital Lab Manual and lab software with 20 laboratory projects. Hands-on activities enable you to truly experience the fundamentals of today's computer science.

This book aims to be a single point of reference for advances in the care of geriatric populations across medical and surgical specialties. The aging population is a unique demographic with its own health challenges. Geriatricians are specifically trained to address these challenges but few medical students or residents enter geriatrics, even as the demand for geriatric expertise increases. The practices of many medical and surgical specialists are dominated by older patients who may themselves see many specialists but rarely visit geriatricians. This updated edition elucidates the most common medical conditions seen in aging patients and translates approaches to those conditions for physicians across specialties. Divided into three sections that assemble crosscutting issues, medical specialties, and surgical and related specialties, this book serves as a guide for clinicians of all backgrounds who will work with older patients as the demographic ages further. This second edition of Geriatrics for Specialists expands the number of specialist chapters to reflect growth in research in aging and clinical care for older people in dermatology, plastic surgery, and behavioral neurology. All original chapters from the first edition are extensively revised and updated to reflect the rapid growth of new knowledge in the field.

This book aims to be a single point of reference for advances in the care of geriatric populations across medical and surgical specialties. The aging population is a unique demographic with its own health challenges. Geriatricians are specifically trained to address these challenges but few medical students or residents enter geriatrics, even as the demand for geriatric expertise increases. The practices of many medical and surgical specialists are dominated by older patients who may themselves see many specialists but rarely visit geriatricians. This updated edition elucidates the most common medical conditions seen in aging patients and translates approaches to those conditions for physicians across specialties. Divided into three sections that assemble crosscutting issues, medical specialties, and surgical and related specialties, this book serves as a guide for clinicians of all backgrounds who will work with older patients as the demographic ages further. This second edition of Geriatrics for Specialists expands the number of specialist chapters to reflect growth in research in aging and clinical care for older people in dermatology, plastic surgery, and behavioral neurology. All original chapters from the first edition are extensively revised and updated to reflect the rapid growth of new knowledge in the field.

Since the Founding, America’s faith in a democratic republic has depended on citizens who could be trusted to be communicators. Vigorous talk about equality, rights, and collaboration fueled the revolution, the Declaration of Independence, and the Constitution with its amendments. In a republic, the people set the terms for their lives not individually, but in community. The genius of keeping it alive exists in how everyday citizens talk and listen, write and read, for a common good. Dialogue and deliberation—rather than an accumulation of individual preferences—sustains a republic, yet a diminished and scarred institution of journalism jeopardizes citizens’ access to shared and truthful information. A disturbing “what’s in it for me?” attitude has taken over many citizens, and a creeping, autocratic sense of dismissive accusation too often characterizes the political style of elected officials.The basic fuel for democracy is the willingness of informed citizens to take each other seriously as they talk about political choices. Once we begin to clam up, build walls, and dismiss each other, we unravel the threads tying us to the Founders’ vision of a republic. A free press and free speech become meaningless if not supported by sustained listening to multiple positions. There are those who profit by dividing citizens into two camps: a comfortable “us” versus a scary “them.” They make their case with accusations and often with lies. They warp the very meaning of communication, hoping citizens never truly discover each other’s humanity. Democracy’s News discusses today’s problems of public communication in the context of history, law, and interpersonal life. News should not be something to dread, mistrust, or shun. Aided by reliable, factual journalism, citizens can develop a community-based knowledge to cope with social issues great and small. They come to treat neighbors and strangers as more than stereotypes or opponents. They become collaborators with whom to identify and sustain a working republic where news, citizenship, and public discourse merge.

Although the field of deliberative civic engagement is growing rapidly around the world, our knowledge and understanding of its practice and impacts remain highly fragmented. Democracy in Motion represents the first comprehensive attempt to assess the practice and impact of deliberative civic engagement. Organized in a series of chapters that address the big questions of deliberative civic engagement, it uses theory, research, and practice from around the world to explore what we know about, how we know it, and what remains to be understood. More than a simple summary of research, the book is designed to be accessible and useful to a wide variety of audiences, from scholars and practitioners working in numerous disciplines and fields, to public officials, activists, and average citizens who are seeking to utilize deliberative civic engagement in their communities. The book significantly enhances current scholarship, serving as a guide to existing research and identifying useful future research. It also has promise for enhancing practice, for example by helping practitioners, public officials, and others better think through and articulate issues of design and outcomes, thus enabling them to garner more support for public deliberation activities. In addition, by identifying what remains to be learned about public deliberation, practitioners and public officials may be inspired to connect with scholars to conduct research and evaluations of their efforts.

John R. Searle is one of the world's leading philosophers. During his long and outstanding career, he has made groundbreaking and lasting contributions to the philosophy of language, to the philosophy of mind, as well as to the nature, structure, and functioning of social reality. This volume documents the 13th Munster Lectures on Philosophy with John R. Searle. It includes not only 11 critical papers on Searle's philosophy and Searle's replies to the papers, but also an original article by John R. Searle on his overall philosophical enterprise entitled "The Basic Reality and the Human Reality". "I think Munster is probably unique among contemporary universities in its ability to produce such a high level of philosophical production from their philosophy students." - John R. Searle