This book presents a detailed examination of the physical properties of proteins and their associations with solvents, ligands, and each other. Incorporating observations from his classic work on the thermodynamics of protein-protein and protein-ligand interactions, the internationally recognized author offers a complete conceptual and quantitative description of proteins and their associations. The book begins with an overview of basic thermodynamic principles and goes on to describe the covalent and noncovalent binding of single and multiple ligands and their effects on protein-protein associations. Discussions of protein-solvent interactions address issues including protein folding, membrane associations, and protein dynamics. Attention is given to the effect of temperature and pressure on protein structure, oligomerization, and ligand binding, as well as to ideas about the basis of biological specificity. Although experimental work is discussed throughout the text, the book is not technique oriented. Its theoretical framework is clear, general and easily understandable, making this an essential textbook for beginning graduate students in biological sciences, as well as a valuable reference for advanced researchers in industry and academia.

A long-overdue guide on how to use statistics to bring clarity, not confusion, to policy work. Statistics are an essential tool for making, evaluating, and improving public policy. Statistics for Public Policy is a crash course in wielding these unruly tools to bring maximum clarity to policy work. Former White House economist Jeremy G. Weber offers an accessible voice of experience for the challenges of this work, focusing on seven core practices:  Thinking big-picture about the role of data in decisions Critically engaging with data by focusing on its origins, purpose, and generalizability Understanding the strengths and limits of the simple statistics that dominate most policy discussions Developing reasons for considering a number to be practically small or large   Distinguishing correlation from causation and minor causes from major causes Communicating statistics so that they are seen, understood, and believed Maintaining credibility by being right (or at least respectably wrong) in every setting Statistics for Public Policy dispenses with the opacity and technical language that have long made this space impenetrable; instead, Weber offers an essential resource for all students and professionals working at the intersections of data and policy interventions. This book is all signal, no noise.

The field of healthcare epidemiology and infection prevention is evolving with the emergence of new pathogens, new resistance patterns, new treatment options, and new pressures for performance improvement. In addition to the changing landscape of the field, public and regulatory scrutiny has highlighted the importance of following best clinical practices when managing patients with known or suspected healthcare-associated infections (HAIs). Healthcare Associated Infections aims to equip clinicians and healthcare workers to effectively manage commonly encountered HAIs through succinct, case-based discussion. The book is perfect for use as a quick reference for busy clinicians seeking advice on the management of challenging patients, for infection preventionists wishing to learn more about the clinical management of these infections, or for trainees looking for an engaging introduction to a field that must be mastered by any clinician with an inpatient practice. Part of the Oxford American Infectious Disease Library, each chapter presents a series of cases to provide a framework for discussing commonly encountered pathogens that cause HAIs and the most important points regarding the diagnosis and treatment of patients with these infections. Brief, clinically pertinent introductions to the prevention of HAI are integrated within the discussion of each case.

A long-overdue guide on how to use statistics to bring clarity, not confusion, to policy work. Statistics are an essential tool for making, evaluating, and improving public policy. Statistics for Public Policy is a crash course in wielding these unruly tools to bring maximum clarity to policy work. Former White House economist Jeremy G. Weber offers an accessible voice of experience for the challenges of this work, focusing on seven core practices:  Thinking big-picture about the role of data in decisions Critically engaging with data by focusing on its origins, purpose, and generalizability Understanding the strengths and limits of the simple statistics that dominate most policy discussions Developing reasons for considering a number to be practically small or large   Distinguishing correlation from causation and minor causes from major causes Communicating statistics so that they are seen, understood, and believed Maintaining credibility by being right (or at least respectably wrong) in every setting Statistics for Public Policy dispenses with the opacity and technical language that have long made this space impenetrable; instead, Weber offers an essential resource for all students and professionals working at the intersections of data and policy interventions. This book is all signal, no noise.

Die vorliegende Dissertation entstand w!hrend meiner T!tig- keit als wissenschaftlicher Mitarbeiter am Fraunhofer-Insti- tut fur Produktionstechnik und Automatisierung (IPA) in stuttgart. Herrn Professor Dr. -Ing. H. J. Warnecke, dem Direktor des Instituts, bin ich fur seine wohlwollende Forderung der Ar- 'beit zu besonderem Dank verpflichtet. Herrn Professor DTech. h. c. Dipl. -Ing. K. Tuffentsammer danke ich fur die eingehende Durchsicht der Arbeit und die sich daraus ergebenden Hinweise. Ein herzlicher Dank geht ferner an Herrn Professor Dr. -Ing. habil H. J. Bullinger fur seine konstruktive Kritik. Bei allen Mitarbeitern des Instituts, die mir bei der Fertig- stellung dieser Arbeit behilflich waren, bedanke ich mich recht herzlich. Dieser Dank gilt insbesondere Herrn Dr. -Ing. J. Warschat, Herrn Dr. -Ing. H. -J. Kolle und Dipl. -Wirtsch. -Ing. T. Kraus, die durch wertvolle Kritik und Anregung zu dieser Arbeit bei- getragen haben. stuttgart, April 1983 Gerald Weber INHALTSVERZEICHNIS seite o ABKURZUNGEN UND FORMELGROSSEN 13 1 EINLEITUNG 20 2 AUFGABENSTELLUNG UND ABGRENZUNG DES UNTER- 22 SUCHUNGSBEREICHES 2. 1 Aufgabenste11ung und Vorgehensweise 22 2. 2 Vorhandene Arbeiten zum Problemkreis 29 2. 3 Zielsetzung 31 32 3 SYSTEMATIK ZUR ENTWICKLUNG VON GESTALTUNGS- REGELN FUR EIN INTEGRIERTES PRODUKTIONS- SYSTEM 3. 1 Vorgehensweise zur Systematisierung von 32 Zie1en und Funktionen des Produktions- systems 3. 2 Vorgaben der Unternehmensplanung an das 33 Produktionssystem 3. 2. 1 Vorgaben zur Erh6hung der Kapita1renta- 33 bilitiit 3. 2. 2 Vorgaben zur Erh6hung der F1exibilitiit 35 3. 3 Zielsystem der Produktion 39 39 3. 3.

Beth MacLaird, the beautiful daughter and apprentice to a skillful doctor, is prepared to fill-in as town doctor in Winona, Minnesota, while her father and brother serve the Union Army. But Captain Adam Brentwood, in search of the Army doctor he believes to be a criminal, is totally unprepared to fall in love with Beth. War rips apart Beth's family, as it does so many men's bodies, until finally the lady slips into men's clothing and marches onto the gruesome battlefield herself in an attempt to put back together as many lives as possible. But will Adam ever recover the wildflower he lost? And can they ever be the same again?

Remote electronic voting is a promising concept. Voters are enabled to cast their votes over the Internet, from arbitrary computers. It offers convenience and does not require geographical proximity on the election day. Thus, it has the potential to allure those groups of voters that regularly abstain from general elections. However, in order to implement free and secret electronic elections, the threats of vote buying and coercion against the voters need to be addressed. In this book, a cryptographic approach that deals with these issues is investigated. Especially, a cryptographic voting protocol is described, evaluated and prototypically implemented that offers mechanisms to protect voters against coercion and thwarts vote buying. Readers of this book would include graduate students and postgraduate researchers in both academia and industry, who wish to gain a deeper knowledge of cryptographic voting protocols, its underlying theoretical concepts and its potential capabilities.

"The first comprehensive text on stress and crisis management specifically tailored to courses focusing on the family "Organized by stress model, this book helps readers understand the relationships among models, research, crisis prevention, and crisis management with individuals and families. Providing a balance of theory, research, hands-on applications, and intervention strategies, this innovative text presents a comprehensive overview of the field. Intended AudienceIndividual and Family Stress and Crises is ideal as a core text for upper division undergraduate and graduate students in courses such as Family Crisis, Family Stress & Coping, and Dysfunctions in Marriage & Family.