Hardbound. Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists.Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research.This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.

Hardbound. In this volume, there are five reviews of topical subjects. The availability of drugs for the successful treatment of many diseases results in an increase in the number of people who live to their eighties and nineties at which time Alzheimer's disease is most prevalent. The steady progress which is being made in our understanding of this complex disease and in the development of drugs for its treatment are reviewed in Chapter 1. Chemotherapy of another disease which often resists treatment may have another weapon in its armoury if recent work on modifying a naturally occurring anticancer compound (camptothecin) succeeds in reducing its side-effects; recent efforts in this field (described in Chapter 2) may yield a drug of value in treating cancer of the colon and stomach.Transporting a drug molecule to a specific site of action continues to present a challenge. The use of phosphates and phosphonates to protect the drug from hydrolysis or o

This book classifies methods of synthesizing a heterocyclic ring which is fused to another ring. Classification is based on the functional group or groups present in the substrate, each chapter being devoted to the reactions of a particular pair of groups. The groups are arranged alphabetically so that they can be found easily. The book enables the reader to locate references (over 2000 are included) to the conversion of a wide variety of functional groups into heterocyclic rings of five to eight atoms. Each cyclization is shown as an equation which contains concise details or reagents, conditions, and yields. Since the classification of each cyclization is based on the functional groups involved, locating the relevant reference is independent of the identity of the ring in the substrate. This simplifies the search for the relevant reference.