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Escherichia coli is a facultative anaerobic Gamma-proteobacterium,
which belongs to the family Enterobacteriaceae. While being an
important constituent of the normal gut microbiota, specialized E.
coli clones have acquired genetic elements that allow them to
compete with the endogenous commensals, colonise normally sterile
niches and cause disease. E. coli pathotypes can cause intestinal
and extra intestinal infections (e.g. UTI, sepsis) and associate
with mammalian cells while being extra- or intra-cellular. In
recent years, E. coli infections have become a serious clinical
problem, due to the rapid spread of antibiotic resistance. Thus,
infections with intestinal E. coli (e.g. E. coli O104) or
extraintestinal pathogenic strains (e.g. E. coli ST131) are
becoming difficult to treat and are often lethal. Consequently,
there is a pressing need to develop alternative control measures,
including the identification of new drug targets and development of
vaccines that offer lasting protection. This volume focuses on
several types of E. coli infections (intestinal and
extraintestinal), virulence factors, and E. coli pandemics. It
addresses the problem of antibiotic resistance, and a dedicated
chapter discusses the need to develop alternative control measures.
Given its depth and breadth of coverage, the book will benefit all
those interested in the biology, genetics, physiology and
pathogenesis of E. coli, and in related vaccine development.
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