Escherichia coli, a Versatile Pathogen (Hardcover, 1st ed. 2018)

Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Current Topics in Microbiology and Immunology, 416
Release date:	November 2018
First published:	2018
Editors:	Gad Frankel • Eliora Z. Ron
Dimensions:	235 x 155 x 16mm (L x W x T)
Format:	Hardcover
Pages:	242
Edition:	1st ed. 2018
ISBN-13:	978-3-319-99663-9
Categories:	Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Bacteriology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases > General
LSN:	3-319-99663-0
Barcode:	9783319996639

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