Heterocycles bearing a triazole ring residue are reported to show anticancer, anti-inflammatory, analgesic, antifungal, antitubercular, antimicrobial, antiviral, antioxidant, CNS depressant, and plant growth regulatory activity etc. Keeping in view the importance of Triazole from the literature survey I found various triazole derivatives & from that I planned to work the substituted triazole derivatives from m-nitro benzoic acid, which gives various anticipated biological activities. Among the all synthesized compound, compound 6-(2-chloro-phenyl)-3-(4-nitro-phenyl)- 1,2,4]triazolo 3,4-b] 1,3,4]thiadiazole (PLP 105b) with MIC value of (16ug/ml) against gram-positive (B.subtilis) and (16ug/ml) against gram-negative (E.coli, p.aeroginosa)and the compound3,6-bis-(4-nitro-phenyl)- 1,2,4]triazolo 3,4-b] 1,3,4]thiadiazole (PLP 105d) with MIC value of (16ug/ml) against gram-negative (p.aeroginosa) give better antimicrobial activity than other synthesized compound."

Artocarpus heterophyllus found wild in the forest region, fruit are multiple seeded containing mucilage. Acetone precipitation method is used to isolate mucilage. The physicochemical characteristic of mucilage has performed such as swelling index, solubility, LOD. This study was carried out to compare the binding effects of isolated mucilage with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner's ratio, Carr's index and tablet properties using standard methods. Mucilage of varying concentrations of 4, 6 and 8%w/w were used to produce paracetamol granules by wet granulation method and compressed. An increase in binder concentration led to decrease in friability and increase in disintegration time of the tablets. The results indicate that mucilage obtained from Artocarpus heterophyllus fruit possesses comparable binding properties.