Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions.This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics: Record keeping and equipment Solvent purification and reagent preparation Using gases and working with vacuum pumps Purification, including crystallization and distillation Small-scale and large-scale reactions Characterization, including NMR spectra, melting point and boiling point, and microanalysis Efficient ways to find information in the chemical literature With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.

Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions.
This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics:

• Record keeping and equipment
• Solvent purification and reagent preparation
• Using gases and working with vacuum pumps
• Purification, including crystallization and distillation
• Small-scale and large-scale reactions
• Characterization, including NMR spectra, melting point and boiling point, and microanalysis
• Efficient ways to find information in the chemical literature

With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.

This clear and concise text is concerned with the reactions used in stereoselective organic synthesis. These are important types of reactions which can be used for the selective preparation of new organic compounds with a defined and predictable three dimensional architecture. It is fully illustrated throughout, with set problems and suggestions for further reading to accompany each chapter.

All students studying organic chemistry need a good understanding of the methods of asymmetric synthesis. In a single volume, many of the most important methods of asymmetric sysnthesis are covered. In self-contained chapters it provides the principles of asymmetric additions to carbonyls, enolate alkylation, aldol reactions, additions to C-C double bonds, reduction and oxidation, rearrangements and hydrolysis/ esterification reactions. Examples of the application in synthesis of natural products are given, and selected examples are used to illustrate the various topics.