This three-book set is devoted to the prominent bays of the Western North America. The first volume describes San Francisco Bay - a shallow estuary surrounded by a large population center. The forces that built it began with plate tectonics and involved the collision of the Pacific and North American plates and the subduction of the Juan de Fuka plate. Gold mining during the California gold rush sent masses of slit into the Bay. The second volume is devoted to San Diego Bay, which is also a shallow estuary surrounded by a large human population center that influenced the Bay. The third volume describes Puget Sound - a different sort of bay - a complex fjord-estuary system, but also surrounded by several large population centers. The watershed is enormous, covering nearly 43,000 square kilometers with thousands of rivers and streams. Geological forces, volcanos, Ice Ages, and changes in sea levels make the Sound a biologically dynamic and fascinating environment, as well as a productive ecosystem. Key Features Summarizes a complex geological, geographical, and ecological history Reviews how the San Diego Bay has changed and will likely change in the future Examines the different roles of various drivers of Bay ecosystem function Includes the role of humans-both first people and modern populations-on the Bay Explores San Diego Bay as an example of general bay ecological and environmental issues

The Puget Sound is a complex fjord-estuary system in Washington State that is connected to the Pacific Ocean by the Juan de Fuca Strait and surrounded by several large population centers. The watershed is enormous, covering nearly 43,000 square kilometers with thousands of rivers and streams. Geological forces, volcanos, Ice Ages, and changes in sea levels make the Sound a biologically dynamic and fascinating environment, as well as a productive ecosystem. Human activity has also influenced the Sound. Humans built several major cities, such as Seattle and Tacoma, have dramatically affected the Puget Sound. This book describes the natural history and evolution of Puget Sound over the last 100 million years through the present and into the future. Key Features Summarizes a complex geological, geographical, and ecological history Reviews how the Puget Sound has changed and will likely change in the future Examines the different roles of various drivers of the Sound's ecosystem function Includes the role of humans-both first people and modern populations. Explores Puget Sound as an example of general bay ecological and environmental issues

The Puget Sound is a complex fjord-estuary system in Washington State that is connected to the Pacific Ocean by the Juan de Fuca Strait and surrounded by several large population centers. The watershed is enormous, covering nearly 43,000 square kilometers with thousands of rivers and streams. Geological forces, volcanos, Ice Ages, and changes in sea levels make the Sound a biologically dynamic and fascinating environment, as well as a productive ecosystem. Human activity has also influenced the Sound. Humans built several major cities, such as Seattle and Tacoma, have dramatically affected the Puget Sound. This book describes the natural history and evolution of Puget Sound over the last 100 million years through the present and into the future. Key Features Summarizes a complex geological, geographical, and ecological history Reviews how the Puget Sound has changed and will likely change in the future Examines the different roles of various drivers of the Sound's ecosystem function Includes the role of humans-both first people and modern populations. Explores Puget Sound as an example of general bay ecological and environmental issues

Summarizes a complex geological, geographical and ecological history Reviews how the San Diego Bay has changed and will likely change in the future Examines the different roles a various drivers of Bay ecosystem function Includes the role of humans - both first people and modern populations - on the Bay Explores San Diego Bay as an example of general bay ecological and environmental issues

San Francisco Bay is a shallow estuary surrounded by a large population center. The forces that built it began with plate tectonics and involved the collision of the Pacific and North American plates and the subduction of the Juan de Fuka plate. Changes in the climate resulting from the last ice age yielded lower and then higher sea levels. Human activity influenced the Bay. Gold mining during the California gold rush sent masses of slit into the Bay. Humans have also built several major cities and filled significant parts of the Bay. This book describes the natural history and evolution of the SF Bay Area over the last 50 million years through the present and into the future. Key selling features: Summarizes a complex geological, geographical and ecological history Reviews how the San Francisco Bay has changed and will likely change in the future Examines the different roles and various drivers of Bay ecosystem function Includes the role of humans - both first peoples and modern populations - on the Bay Explores San Francisco Bay as an example of general bay ecolgical and environmental issues

San Francisco Bay is a shallow estuary surrounded by a large population center. The forces that built it began with plate tectonics and involved the collision of the Pacific and North American plates and the subduction of the Juan de Fuka plate. Changes in the climate resulting from the last ice age yielded lower and then higher sea levels. Human activity influenced the Bay. Gold mining during the California gold rush sent masses of slit into the Bay. Humans have also built several major cities and filled significant parts of the Bay. This book describes the natural history and evolution of the SF Bay Area over the last 50 million years through the present and into the future. Key selling features: Summarizes a complex geological, geographical and ecological history Reviews how the San Francisco Bay has changed and will likely change in the future Examines the different roles and various drivers of Bay ecosystem function Includes the role of humans - both first peoples and modern populations - on the Bay Explores San Francisco Bay as an example of general bay ecolgical and environmental issues

Summarizes a complex geological, geographical and ecological history Reviews how the San Diego Bay has changed and will likely change in the future Examines the different roles a various drivers of Bay ecosystem function Includes the role of humans - both first people and modern populations - on the Bay Explores San Diego Bay as an example of general bay ecological and environmental issues

In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques have been used in less traditional ways with exciting results. Modern Protein Chemistry: Practical Aspects describes the practical side of advanced techniques in protein chemistry. The book gives researchers an excellent "cost-benefit" analysis of these techniques. The contributors have been selected for their prominence in their specific fields and because they run laboratories that actively collaborate with other scientists. Researchers and practitioners, both beginners and experienced, who are looking for new ideas and who are interested in applying these more advanced methods will be assisted in their work by these commentaries. This guide provides hands-on information to complement theoretical understanding. The theory behind these methods can be found in existing books and in the original literature. However, no other guide will help you make a practical evaluation of these methods and their value to your work.

Antibodies protect us from a wide range of infectious diseases and cancers and have become an indispensable tool in science-both for conventional immune response research as well as other areas related to protein identification analysis. This second edition of Making and Using Antibodies: A Practical Handbook provides clear guidance on all aspects of how to make and use antibodies for research along with their commercial and industrial applications. Keeping pace with new developments in this area, all chapters in this new edition have been revised, updated, or expanded. Along with discussions of current applications, new material in the book includes chapters on western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present clear descriptions of basic methods for making and using antibodies and supply detailed descriptions of basic laboratory techniques. Each chapter begins with introductory material, allowing for a better understanding of each concept, and practical examples are included to help readers grasp the real-world scenarios in which antibodies play a part. From the eradication of smallpox to combating cancer, antibodies present an attractive solution to a range of biomedical problems. They are relatively easy to make and use, have great flexibility in applications, and are cost effective for most labs. This volume will assist biomedical researchers and students and pave the way for future discovery of new methods for making and using antibodies for a host of applications.

In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques have been used in less traditional ways with exciting results. Modern Protein Chemistry: Practical Aspects describes the practical side of advanced techniques in protein chemistry. The book gives researchers an excellent "cost-benefit" analysis of these techniques.

The contributors have been selected for their prominence in their specific fields and because they run laboratories that actively collaborate with other scientists. Researchers and practitioners, both beginners and experienced, who are looking for new ideas and who are interested in applying these more advanced methods will be assisted in their work by these commentaries.

This guide provides hands-on information to complement theoretical understanding. The theory behind these methods can be found in existing books and in the original literature. However, no other guide will help you make a practical evaluation of these methods and their value to your work.

This volume provides an overview of a variety of approaches to biological image analysis, which allow for the study of living organisms at all levels of complexity and organization. These organisms range from individual macromolecules to subcellular and cellular volumes, tissues and microbial communities. Such a "systems biology" understanding of life requires the combination of a variety of imaging techniques, and with it an in-depth understanding of their respective strengths and limitations, as well as their intersection with other techniques. Howard, Brown, and Auer show us that the integration of these imaging techniques will allow us to overcome the reductionist approach to biology that dominated the twentieth century, which was aimed at examining the physical and chemical properties of life's constituents, one macromolecule at a time. However, while based on the laws of physics and chemistry, life is not simply a set of chemical reactions and physical forces; it features an exquisite spatiotemporal organization that allows an inconceivably large number of chemical processes to coexist, refined by billions of years of evolutionary experimentation.
And yet, many fundamental questions remain largely unanswered; Imaging Life argues that we are just now beginning to address the spatiotemporal organizational component of living processes. "Imaging" is needed in order to reveal the spatiotemporal relationships between components, and thus to understand organizational guiding principles of living systems. Only through imaging will we be able to decipher the mechanisms and the marvelous organization that enable and sustain the mystery of life. Imaging Life shows us how biology is beginning to do just that.

How does death help us understand the living? Death is more than the last event of life; it is interwoven into our growth, development, protection against disease, and more. It influences the direction of entire species via the cycle of a lifespan, and it involves asking many fascinating questions. How do we differentiate between life and death, though? How do we know when a person, animal, or cell is really dead? How much grey area is there in the science? Why do we age? Can we do anything about it? Scientifically, there's much we can learn about a living thing from its cells. In all living things, cells seem to carry "death" gene programs. Some living organisms have created systems to use these to their own advantage. Humans, for example, use the death of specific cells to hone our immune system and to give us fingernails and hair. Perhaps the most dramatic use occurs during the metamorphosis of insects and frogs. Even single-celled organisms use "quorum sensing" to eliminate some cells to ensure the overall survival of their colony in harsh environments. Thus, there is more to death than just dying. This latest book from science writer Gary C. Howard ties together the many ways that death helps us understand life. He synthesizes the involvement and relation of cells, tissues, organisms, and populations, explaining what happens at the end of life. Between discussions about popular topics such as the ethics of extending life and cell regeneration, Howard also answers fascinating questions about life and death. The resulting book examines how the end of life is determined and what we can learn from this process.