Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature.
The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.

This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.