This comprehensive publication draws together the important aspects
of carcinogen-cell interaction. This interesting work describes the
regulation of normal cell proliferation, cellular responses to
carcinogen damage, the biologic consequences of cellular DNA
modification, the structural and genomic changes resulting from
carcinogen insult, and the possible involvement of such changes in
the conversion of normal human fibroblasts to malignant cells. It
presents current reviews with up-to-date literature references and
provides critical information from leading investigators that is
essential in understanding the biology of human cell
transformation. This volume is especially useful to advanced
students in genetic toxicology, molecular biologists, and all who
are interested in the molecular and macromolecular changes in human
cells leading to neoplasia.
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