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First published in 1986: This book is to help medical, pharmacy,
and advanced students in science to understand the growing
importance of continuously advancing biochemical concepts in human
disease.
First published in 1986: This book is to help medical, pharmacy,
and advanced students in science to understand the growing
importance of continuously advancing biochemical concepts in human
disease.
First published in 1986: This book is to help medical, pharmacy,
and advanced students in science to understand the growing
importance of continuously advancing biochemical concepts in human
disease.
First published in 1986: This book is to help medical, pharmacy,
and advanced students in science to understand the growing
importance of continuously advancing biochemical concepts in human
disease.
Apoptosis is a fascinating concept for the basic scientist. This is
not only because of the multifaceted variety of proposed and
discovered mechanisms, but because apoptosis represents a
fundamental pathway for cell renewal. The study of apoptosis has
resulted in an array of discoveries on signal transduc tion and
downstream effects that have facilitated and advanced many fields
in biology, including research on cancer and other diseases. Thus,
the apoptotic process can be viewed as the largest effort of the
scientific community to understand how cells work and tissues
assemble or remodel. The most direct consequence of this
accumulated knowledge is a greater understanding of disease and
pathological mechanisms. The end result of these efforts will be
significant contributions to health and the adoption of new, never
anticipated, therapeutic approaches. This book represents the
summation of considerable effort from a significant group of
contributors from all over the world as well as from its editors.
In this fashion, many viewpoints have been collected and SUbjected
to thorough academic discussion. The concepts contained in this
medically important volume will stimulate and renew the ideas of
scientists and indeed, will generate additional work to advance
biological knowledge even further. The emphasis of this volume
cements what has been established, adds what has not been explored
fully, and creates a fertile ground for further hypotheses that
will lead to a more complete understanding of the apoptotic
process."
The advances in science and medicine we are now experiencing are
unprec edented and exciting. Life expectancy is prolonged, and
quality of life is much improved. We learn of fabulous new
discoveries made at the bench or the bedside every week. Many
diseases have been totally eliminated, others can be significantly
improved by new therapeutic formulations. Much of the success can
be attributed to a better understanding of disease processes and
the specific targeting of new and more effective medications. As is
the case in many areas of successful human endeavour, there can be
a downside. In the case of drugs and chemicals it is their adverse
effects which are of concern. Of course, every effort is made to
devise medications that are safe, and the need to elucidate and
understand mechanisms are crucial, yet adverse effects remain a
problem. They can be unpredictable and diverse. Drugs have been
shown to induce virtually the whole gamut of human liver pathology
from acute fulminant hepatitis to chronic active hepatitis to
cirrho sis and even malignancy. Hence the possibility of adverse
drug effects must be considered in the differential diagnosis of
many patients with liver disease. This is well recognized and is
very important; indeed, removal of the offending agent can often
lead to reversal of the adverse effect. This is an area of
hepatology where we can really make a difference."
This book is concernced with the process of cell death in human cells by programmed cell death or apoptosis, and the modulation of this process by drugs. This is a new field of study and this volume represents the first comprehensive treatment of this subject matter. Its focus is on human biology and medicine. Apoptosis is a very prevalent type of cell death with importance in human diseases such as cancer, Alzheimer's disease and autoimmune disorders. The book combines the expertise of leading scientists and writers from fields as diverse as neurosciences, immunology, pathology and cancer research. There is detailed analysis of the molecular and cellular aspects of apoptosis including the specific genes and molecules involved in the regulation of this special form of programmed cell death. Scientists, clinicians and researchers involved in studies of human biology and medicine will find this book an excellent resource.
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