Prominent experts in biodefense research-many from the US Army Medical Research Institute of Infectious Diseases-authoritatively delineate the universe of scientific, medical, and legal issues facing the biodefense research community. Regarding medical countermeasures and decontamination, the authors describe the treatment and pathogenesis of a variety of established pathogens (anthrax, plague, smallpox, Brucellosis, Glanders, and Coxiella burnettii) and review what is known about the aerosol route of infection and decontamination processes. They also examine how to discover the presence of these agents, or other previously unknown biological weapons, and detail the ongoing efforts to counter these agents, including proteomic and genomic analysis as a gateway to better diagnostics, therapeutics, vaccinations, genotyping, and forensics. Additional chapters discuss the development and use technology to identify and characterize these infectious organisms, emerging threats, and the development of countermeasures.