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Volume 1 of this series focused mainly on small molecules which are
intrinsically electroactive. Volume 2 continues to provide current
approaches to real time measurements of essential species in the
central nervous system. It describes microdialysis, a sampling
technique, which facilitates the removal of small volumes of
solution containing the analyte(s) of interest which can be
subsequently separated by chromatography and analyzed by a range of
techniques. These include electrochemistry, UV-Vis spectroscopy,
fluorescence and mass spectroscopy. This approach affords the
opportunity to measure a range of targets in real-time thus
providing access to pharmacokinetic/pharmacodynamics measurements
affording the possibility of measuring the disappearance of a drug
after administration and the subsequent appearance of metabolites.
Microdialysis further affords the ability to sample peptides and
proteins of neurobiological interest.Consistent with the goals of
Volume 1, Volume 2 seeks to provide for scientists in the field of
neurobiology a base of bioanalytical techniques that may not be
familiar to them. Specific examples are provided and the
fundamental basis of the technique is also covered.
This new volume documents the transition from the development of
electrochemical monitoring of brain function, now more than 40
years old, to fundamental neuroscience. This includes the links of
molecular neuroscience to biobehavior, to a molecular understanding
of neurologically-linked diseases and to the investigation of
neuroactive molecules made possible by new detection methodology.
This work should be of interest to a broad audience, especially
those who are engaged in neuroscience research, for example in drug
discovery, but are not familiar with electrochemical methodology.
This book is the third in a series entitled, Compendium of In-Vivo
Monitoring in Real-time Molecular Neuroscience. Its purpose is to
provide a cross-section of research addressing monitoring in the
rodent, and in some cases, the human brain.Detailed understanding
of the neurobiology of the brain is demanding and involves
increasingly wider scope of talent ranging from physicists,
neurobiologists, chemists, molecular biologists and bioengineers.
Coming from varied backgrounds, they do not necessarily understand
how to formulate functional issues in a mutually understandable
way. This aim of this book is to provide information which can
serve as a starting point for understanding such a complex
topic.The authors provide 'tutorial' writing for specialists, as
well as material understandable to a wide audience including
neuroscientists, those interested in drug discovery, and those
using such measurements for diagnosis purposes.
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone
This new volume documents the transition from the development of
electrochemical monitoring of brain function, now more than 40
years old, to fundamental neuroscience. This includes the links of
molecular neuroscience to biobehavior, to a molecular understanding
of neurologically-linked diseases and to the investigation of
neuroactive molecules made possible by new detection methodology.
This work should be of interest to a broad audience, especially
those who are engaged in neuroscience research, for example in drug
discovery, but are not familiar with electrochemical methodology.
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