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Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 2: Microdialysis And Sensing Of Neural Tissues (Hardcover)
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Compendium Of In Vivo Monitoring In Real-time Molecular Neuroscience - Volume 2: Microdialysis And Sensing Of Neural Tissues (Hardcover)
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Volume 1 of this series focused mainly on small molecules which are
intrinsically electroactive. Volume 2 continues to provide current
approaches to real time measurements of essential species in the
central nervous system. It describes microdialysis, a sampling
technique, which facilitates the removal of small volumes of
solution containing the analyte(s) of interest which can be
subsequently separated by chromatography and analyzed by a range of
techniques. These include electrochemistry, UV-Vis spectroscopy,
fluorescence and mass spectroscopy. This approach affords the
opportunity to measure a range of targets in real-time thus
providing access to pharmacokinetic/pharmacodynamics measurements
affording the possibility of measuring the disappearance of a drug
after administration and the subsequent appearance of metabolites.
Microdialysis further affords the ability to sample peptides and
proteins of neurobiological interest.Consistent with the goals of
Volume 1, Volume 2 seeks to provide for scientists in the field of
neurobiology a base of bioanalytical techniques that may not be
familiar to them. Specific examples are provided and the
fundamental basis of the technique is also covered.
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