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This volume focuses on applying the Crispr system in editing the
genome of human cells (in vitro and in vivo) and model
organisms used in biomedical research. With the advent of Crispr
technology, genome editing soon became a procedure of great
interest to laboratories worldwide due to its relative ease and
accuracy. In biomedical sciences, genome editing by Crispr has
already enabled the development of new experimental model systems.
In medicine, therapeutic alternatives for the genetic "correction"
of diseases have already begun to appear. Therefore, the book's
purpose is to bring in a single volume, chapters that show the
scientific community in biomedicine, medicine, human genetics,
oncology, virology, and parasitology, among others, the advances in
genomic editing. In a chapter dedicated to the ethical aspects of
human genomic editing, we also address what we can and should do
with this (bio)technology. The book chapters were written by
productive researchers specializing in Crispr genome editing. The
chapters cover the concept of Crispr and genome editing and how to
use this new methodology in biomedical research and medicine, among
other aspects, including the ethical controversy around its use in
humans. The writing of the chapters keeps a specialized language
intelligible enough for those who want to introduce themselves to
the subject.
After sequencing the human genome a decade ago, researchers have
continued their projects, but now to try to better understand how,
and when, genes are expressed in health and disease. Efforts have
been concentrated on the measurement of the expression of RNA
transcripts. In an analogy to the genome, the term "transcriptome"
was created to refer to the complete set of RNAs in a cell type or
tissue in a particular situation. Transcriptomics is the science
that studies this issue and it is a branch of functional genomics.
Transcriptomics in Heath and Disease provides a comprehensive
overview of the science of transcriptomics initially in health,
focusing on the concept of the transcriptome and the main methods
to evaluate it. The authors discuss the concept and use of gene
expression signatures and transcriptional biomarkers in normal
development and diseased tissues and organs. As the transcriptome
changes depending on the pathology, there is also a focus on the
variations in the gene expression in different diseases such as
autoimmune, inflammation, cancer and infections. This book should
be very useful for researchers in molecular biology focusing on
gene expression, human genetics, immunology, and genomics.
The study of transcriptomics is key to understanding complex
diseases. This new edition will build on the foundation of the
first edition while incorporating the progress that has been made
in the field of transcriptomics in the past six years, including
bioinformatics for data analysis. Written by leading experts,
chapters address new subjects such as methodological advances in
large-scale sequencing, the sequencing of single-cells, and spatial
transcriptomics. The new edition will address how transcriptomics
may be used in combination with genetic strategies to identify
causative genes in monogenic and complex genetic diseases. Coverage
will also explore transcriptomics in challenging groups of
diseases, such as cancer, inflammation, bacterial infection, and
autoimmune diseases. The updated volume will be useful for
geneticists, genome biologists, biomedical researchers, molecular
biologists, bioinformaticians, and students, among others.
This volume focuses on challenging field in biomedicine that is the
genetic control of central immune tolerance. It covers the thymus
development, their cellular components and their respective
function, the peculiar gene expression profiling (transcriptome)
found in the medullary thymic epithelial cells (mTECs) that are
implicated in the self-representation in the thymus, the Autoimmune
regulator (Aire) gene, the mutations in this gene and manifestation
of autoimmune diseases, and the role of cell-cell interactions
within the thymus with implications in the negative selection
(elimination) of nascent autoreactive T cells in preventing
aggressive autoimmunity. The thymus gland is a lymphoid organ
implicated in the maturation, differentiation and selection of T
cells. This organ is gained more and more attention in different
biomedical research labs worldwide due to its function that is
associated with the control of immune homeostasis in the body,
establishing the central immune tolerance and preventing the onset
of autoimmune diseases.
This volume focuses on challenging field in biomedicine that is the
genetic control of central immune tolerance. It covers the thymus
development, their cellular components and their respective
function, the peculiar gene expression profiling (transcriptome)
found in the medullary thymic epithelial cells (mTECs) that are
implicated in the self-representation in the thymus, the Autoimmune
regulator (Aire) gene, the mutations in this gene and manifestation
of autoimmune diseases, and the role of cell-cell interactions
within the thymus with implications in the negative selection
(elimination) of nascent autoreactive T cells in preventing
aggressive autoimmunity. The thymus gland is a lymphoid organ
implicated in the maturation, differentiation and selection of T
cells. This organ is gained more and more attention in different
biomedical research labs worldwide due to its function that is
associated with the control of immune homeostasis in the body,
establishing the central immune tolerance and preventing the onset
of autoimmune diseases.
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