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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Thymus Transcriptome and Cell Biology (Hardcover, 1st ed. 2019)
Loot Price: R4,531
Discovery Miles 45 310
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Thymus Transcriptome and Cell Biology (Hardcover, 1st ed. 2019)
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This volume focuses on challenging field in biomedicine that is the
genetic control of central immune tolerance. It covers the thymus
development, their cellular components and their respective
function, the peculiar gene expression profiling (transcriptome)
found in the medullary thymic epithelial cells (mTECs) that are
implicated in the self-representation in the thymus, the Autoimmune
regulator (Aire) gene, the mutations in this gene and manifestation
of autoimmune diseases, and the role of cell-cell interactions
within the thymus with implications in the negative selection
(elimination) of nascent autoreactive T cells in preventing
aggressive autoimmunity. The thymus gland is a lymphoid organ
implicated in the maturation, differentiation and selection of T
cells. This organ is gained more and more attention in different
biomedical research labs worldwide due to its function that is
associated with the control of immune homeostasis in the body,
establishing the central immune tolerance and preventing the onset
of autoimmune diseases.
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