Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells ) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society."

In 1204, the Byzantine Empire was conquered by troops from western Europe ostensibly taking part in the Fourth Crusade. This was a hugely significant event for the subjects of the Empire, radically altering the Byzantines' self-image and weakening their state for the later conflict with the Ottoman Turks. Using the theory of ethnicity - a comparatively recent tool with regard to the pre-modern era - Gill Page provides fresh insight into the late Byzantine period, providing a corrective to nationalistic interpretations of the period of Frankish rule and more broadly to generally held assumptions of ethnic hostility in the period. A systematic analysis of texts in Greek from the period 1200 1420, from both ends of the social spectrum, is backed up by an in-depth study of Frankish rule in the Peloponnese to reveal the trends in the development of Byzantine identity under the impact of the Franks.

This textbook provides a self-contained introduction to numerical methods in probability with a focus on applications to finance. Topics covered include the Monte Carlo simulation (including simulation of random variables, variance reduction, quasi-Monte Carlo simulation, and more recent developments such as the multilevel paradigm), stochastic optimization and approximation, discretization schemes of stochastic differential equations, as well as optimal quantization methods. The author further presents detailed applications to numerical aspects of pricing and hedging of financial derivatives, risk measures (such as value-at-risk and conditional value-at-risk), implicitation of parameters, and calibration. Aimed at graduate students and advanced undergraduate students, this book contains useful examples and over 150 exercises, making it suitable for self-study.