Angiogenesis is a multi-stage process that drives the generation
of new blood and lymphatic vessels from pre-existing ones. It is
highly active during embryogenesis, largely inactive during
adulthood but reactivated during wound healing and under a number
of pathological conditions including cancer and ocular diseases. In
addition to endothelial cells, which line the walls of the vessels,
several other cell types (pericytes, macrophages, progenitor cells
) also contribute to angiogenesis. A number of signaling pathways
are activated and very finely tune the delicate morphogenetic
events that ultimately lead to the formation of stable blood proof
neovessels.
This book reviews recent advances in our understanding of the
molecular and cellular mechanisms of angiogenesis, with a focus on
how to integrate these observations into the context of
developmental, post-natal and pathological neovascularization.
The book was published under the auspices of the French
Angiogenesis Society. Most contributors are prominent members of
this Society or international researchers who have actively
contributed to the Annual Meetings of the Society."
General
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