Abiotic stresses such as high temperature, low-temperature, drought, and salinity limit crop productivity worldwide. Understanding plant responses to these stresses is essential for rational engineering of crop plants. In Arabidopsis, the signal transduction pathways for abiotic stresses, light, several phytohormones and pathogenesis have been elucidated. A significant portion of plant genomes (most studies are Arabidopsis and rice genome) encodes for proteins involves in signaling such as receptor, sensors, kinases, phosphatases, transcription factors and transporters/channels. Despite decades of physiological and molecular effort, knowledge pertaining to how plants sense and transduce low and high temperature, low-water availability (drought), water-submergence and salinity signals is still a major question before plant biologists. One major constraint hampering our understanding of these signal transduction processes in plants has been the lack or slow pace of application of molecular genomic and genetics knowledge in the form of gene function. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving not only one gene family but multiple genes or gene families, plant biologists can lay a foundation for designing and generating future crops that can withstand the higher degree of environmental stresses (especially abiotic stresses, which are the major cause of crop loss throughout the world) without losing crop yield and productivity. Therefore, in this proposed book, we intend to incorporate the contribution from leading plant biologists to elucidate several aspects of stress signaling by functional genomic approaches.

The regulation of the phosphorylation/dephosphorylation process, resulting in "cellular switches" that monitor normal plant physiology, growth and development, has immense potential in crop systems. With much of the information in the nascent stages, coming largely from Arabidopsis and rice particularly, the use of cell biology, genetic screens, biochemical approaches aided by an omics approach should help unravel the detail functional information available about signaling pathways in plants. The regulation could be exploited to develop crop varieties better equipped to handle changing environments and enhance agricultural productivity. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving phosphatases, one gene family or multiple genes or gene families, plant biologist can lay a foundation for designing and generating future crops, which can withstand the higher degree of environmental stresses. Especially abiotic stresses, which are the major cause of crop loss throughout the world without losing crop yield and productivity. This book incorporates the contributions from leading plant biologists in the field of stress-mediated dephosphorylation by phosphatases as an important task to elucidate the aspects of stress signaling by functional genomic approaches.

Abiotic stresses such as high temperature, low-temperature, drought, and salinity limit crop productivity worldwide. Understanding plant responses to these stresses is essential for rational engineering of crop plants. In Arabidopsis, the signal transduction pathways for abiotic stresses, light, several phytohormones and pathogenesis have been elucidated. A significant portion of plant genomes (most studies are Arabidopsis and rice genome) encodes for proteins involves in signaling such as receptor, sensors, kinases, phosphatases, transcription factors and transporters/channels. Despite decades of physiological and molecular effort, knowledge pertaining to how plants sense and transduce low and high temperature, low-water availability (drought), water-submergence and salinity signals is still a major question before plant biologists. One major constraint hampering our understanding of these signal transduction processes in plants has been the lack or slow pace of application of molecular genomic and genetics knowledge in the form of gene function. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving not only one gene family but multiple genes or gene families, plant biologists can lay a foundation for designing and generating future crops that can withstand the higher degree of environmental stresses (especially abiotic stresses, which are the major cause of crop loss throughout the world) without losing crop yield and productivity.

The regulation of the phosphorylation/dephosphorylation process, resulting in "cellular switches" that monitor normal plant physiology, growth and development, has immense potential in crop systems. With much of the information in the nascent stages, coming largely from Arabidopsis and rice particularly, the use of cell biology, genetic screens, biochemical approaches aided by an omics approach should help unravel the detail functional information available about signaling pathways in plants. The regulation could be exploited to develop crop varieties better equipped to handle changing environments and enhance agricultural productivity. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving phosphatases, one gene family or multiple genes or gene families, plant biologist can lay a foundation for designing and generating future crops, which can withstand the higher degree of environmental stresses. Especially abiotic stresses, which are the major cause of crop loss throughout the world without losing crop yield and productivity. This book incorporates the contributions from leading plant biologists in the field of stress-mediated dephosphorylation by phosphatases as an important task to elucidate the aspects of stress signaling by functional genomic approaches.

G proteins are the key regulators for a wide range of cellular processes in animals and plants. In comparison to animals and yeast, plants have a single Rho-GTPase subfamily called Rho-like GTPases (ROPs). The ROP family of monomeric GTPases has emerged as a versatile and key regulator in plant signal transduction processes. During the past few years' studies on plant RHO-type (ROP) GTPase have generated new insights into their role in diverse processes ranging from cytoskeletal organization, polar growth, development to stress and hormonal responses. Studies have shown that plants have evolved specific regulators and effector molecules. ROP GTPases possess the ability to interact with these multiple regulator and effector molecules that ultimately determines their signaling specificity. Recently, genome wide studies in plants have shown that the Arabidopsis genome encodes 93, and rice has nearly 85 small GTPase homologs. And we have been able to identify four new homologs in the rice genome. Here, we focus on the complete phylogenetic, domain, structural and expression analysis during stress and various developmental processes of small GTPases in plants. The comparison of gene expression patterns of the individual members of the GTPase family may help to reveal potential plant specific signaling mechanisms and their relevance. Also, we are summarizing the role of currently known ROP GTPases and their interacting proteins with brief description, simultaneously, comparing their expression pattern based on microarray data. Overall, we will be discussing the functional genomic perspective of plant Rho like GTPases and their role in regulating several physiological processes such as stress, hormonal, pollen tube, root hair-growth and other developmental responses.

Calcium plays pivotal role in regulating the physiological as well as developmental processes in plants. Till now, several calcium sensors have been discovered, which regulate the diverse signaling pathways involved in plant growth and development. One of the major calcium sensors CBL (calcineurin B-like) is decoding the calcium signal during various environmental stresses in plants. Calcium mediated signal is transduced downstream by CBL-interacting protein kinases (CIPKs), which generally phosphorylate the target proteins such as transcription factors or transporters/channel leading to a response. Mutant based approach has provided valuable information in the functional analysis of individual members of CBL and CIPK gene family in Arabidopsis. Both CBL and CIPK gene families have previously been identified and characterized in Arabidopsis and rice. Identification and characterization of CBLs and CIPKs in other plant species such as Oryza sativa, Pisum sativum, Cicer arietinum, Zea mays, Populus euphratica, Vitis vinifera, Malus domestica, Gossypium hirsutum, Sorghum bicolor, Brassica napus, Vicia faba, Phaseolus vulgaris, Ammopiptanthus mongolicus and Triticum aestivum are still in juvenile stage. Overall, Global Comparative Analysis of CBL-CIPK Gene Families in Plants is a comprehensive study focused on the diverse role of CBL-CIPK module in different stress signaling and also to identify a newly emerging role of this calcium-signaling module in plant growth and development across different plant species. In addition, beside Arabidopsis, it will provide backbone of knowledge to perform a detail molecular investigation in crop plant species and could possibly enable in designing strategies to tame abiotic stress tolerance and development in important agronomical crop plants. This book will act as handy and informative source in this field for students as well as advanced researchers.

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. Neuron Navigators (NAV) are also involved in nervous system development "

This book focuses on the significance and implications of Calcium (Ca2+) transport machinery in the plant cell in generating alternating Ca2+ levels and impacting the cell's physiological, biochemical and developmental processes. In the following sections, the concept of Ca2+ homeostasis, Ca2+ signature, various Ca2+ transport protein families and conductance systems would be discussed in detail- elucidation of their functional characterization, structure, mechanism, sub-cellular localization and specific physiological roles in ensuring Ca2+ homeostasis. Also, the aspect of Ca2+ as a "signaling hub" -transducing distinct plant responses to diverse environmental stimuli, Ca2+ binding proteins, and the tools used in studying these proteins are explained in brief to paint a holistic picture of Ca2+ transport in plant systems. This has resulted in an elaborative literature account to serve as a staple by providing recent insights and advance knowledge surrounding genetic and molecular dissection of Ca2+homeostasis maintenance mechanisms and extant Ca2+ transport systems in plants.

Potassium (K+) is an essential mineral macronutrient abundantly present in the cytosol which, unlike other macronutrients, is not metabolized and does not integrate into macromolecules. Compared to animal cells, K+ is more abundantly present in plant cells. Overall performance of the plant, and operation of metabolic machinery depends upon intracellular K+ homeostasis (K+ uptake and efflux) via K+ channels and transporters acting as mediators of cellular responses during plant development. Unlike animals, plants lack sodium/K+ exchangers; plant cells have developed unique transport systems for K+ accumulation and release. In Arabidopsis thaliana, 71 K+ channels and transporters have been identified and categorized into six families. Plant adaptive responses to several abiotic and biotic stresses are mediated by regulation of intracellular K+ homeostasis. In this report, we highlight the role of K+ in abiotic and biotic stresses, features of channels and transporters responsible for its homeostasis along with its evolutionary relationship, perception and sensing mechanisms, and K+ deficiency triggering different signaling cascades. Overall, this book covers the role of K+ in plants would be significantly helpful to research, academic community as well as students to understand the one of the major attributes of plant biology.