This book gives an overview of various interactomes involved in
dorsal ventral (DV) and anterior posterior (AP) guidance, their
mechanisms of action, subcellular localizations, and functional
roles. It will provide readers a better understanding of the
development of the nervous system, which in turn will help to find
cures to various neural and other disorders.
In nematodes there are two types of guidance systems, including
DV and AP guidance. The signaling process that guides the growth
cones along the DV axis has remained intact in both vertebrates and
invertebrates. The adaptor protein UNC-53 appears to play a part in
migration along the AP axis in both worms and their human homologs.
Neuron Navigators (NAV) are also involved in nervous system
development "
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