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Chemical Biology of Natural Products This unique, long-awaited
volume is designed to address contemporary aspects of natural
product chemistry and its influence on biological systems, not
solely on human interactions. The subjects covered include
discovery, isolation and characterization, biosynthesis,
biosynthetic engineering, pharmaceutical, and other applications of
these compounds. Each chapter begins with a brief and simple
introduction to the subject matter, and then proceeds to guide the
reader towards the more contemporary, cutting-edge research in the
field, with the contributing authors presenting current examples
from their own work in order to exemplify key themes. Topics
covered in the text include genome mining, heterologous expression,
natural product synthesis, biosynthesis, glycosylation, chemical
ecology, and therapeutic applications of natural products, both
current and potential.
The approach to drug discovery from natural sources has yielded
many important new pharmaceuticals inaccessible by other routes. In
many cases the isolated natural product may not be an effective
drug for any of several reasons, but it nevertheless may become a
drug through chemical modification or have a novel pharmacophore
for future drug design. In summarizing the status of natural
products as cancer chemotherapeutics, Anticancer Agents from
Natural Products, Second Edition covers the: History of each
covered drug-a discussion of its mechanism on action, medicinal
chemistry, synthesis, and clinical applications Potential for novel
drug discovery through the use of genome mining as well as future
developments in anticancer drug discovery Important biosynthetic
approaches to "unnatural" natural products Anticancer Agents from
Natural Products, Second Edition discusses how complex
target-oriented synthesis-enabled by historic advances in
methodology-has enormously expanded the scope of the possible. This
book covers the current clinically used anticancer agents that are
either natural products or are clearly derived from natural product
leads. It also reviews drug candidates currently in clinical
development since many of these will be clinically used drugs in
the future. Examples include the drugs etoposide and teniposide
derived from the lead compound podophyllotoxin; numerous analogs
derived from taxol; topotecan, derived from camptothecin; and the
synthetic clinical candidates, E7389 and HTI-286, developed from
the marine leads, halichondrin B and hemiasterlin.
Chemical Biology of Natural Products This unique, long-awaited
volume is designed to address contemporary aspects of natural
product chemistry and its influence on biological systems, not
solely on human interactions. The subjects covered include
discovery, isolation and characterization, biosynthesis,
biosynthetic engineering, pharmaceutical, and other applications of
these compounds. Each chapter begins with a brief and simple
introduction to the subject matter, and then proceeds to guide the
reader towards the more contemporary, cutting-edge research in the
field, with the contributing authors presenting current examples
from their own work in order to exemplify key themes. Topics
covered in the text include genome mining, heterologous expression,
natural product synthesis, biosynthesis, glycosylation, chemical
ecology, and therapeutic applications of natural products, both
current and potential.
Encyclopedia of Dietary Supplements presents peer-reviewed,
objective entries that rigorously examine the most significant
scientific research on basic chemical, preclinical, and clinical
data. Designed for healthcare professionals, researchers, and
health-conscious consumers, it presents evidence-based information
on the major vitamin and mineral micronutrients, herbs, botanicals,
phytochemicals, and other bioactive preparations. Supplements
covered include: Vitamins, beta-carotene, niacin, and folate
Omega-3 and omega-6 fatty acids, isoflavones, and quercetin
Calcium, copper, iron, and phosphorus 5-hydroxytryptophan,
glutamine, and L-arginine St. John's Wort, ginkgo biloba, green
tea, kava, and noni Androstenedione, DHEA, and melatonin Coenzyme
Q10 and S-adenosylmethionine Shiitake, maitake, reishi, and
cordiceps With nearly 100 entries contributed by renowned
subject-specific experts, the book serves as a scientific
checkpoint for the many OTC supplements carried in today's
nutritional products marketplace. Also Available OnlineThis Taylor
& Francis encyclopedia is also available through online
subscription, offering a variety of extra benefits for researchers,
students, and librarians, including: Citation tracking and alerts
Active reference linking Saved searches and marked lists HTML and
PDF format options Contact Taylor and Francis for more information
or to inquire about subscription options and print/online
combination packages. US: (Tel) 1.888.318.2367; (E-mail)
[email protected] International: (Tel) +44 (0) 20
7017 6062; (E-mail) [email protected]
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