|
Showing 1 - 2 of
2 matches in All Departments
This textbook presents the current (and near-future) state of
affairs of molecular testing as it pertains to the dermatology
patient. It focuses on practical applications of molecular
diagnostics over a cross-section of dermatologic disease, including
melanoma, lymphoma, soft tissue tumors, genodermatoses, and
infectious disease. It includes practical advice to those ordering
molecular tests as well as to those considering performing such
tests, providing a potential template for a comprehensive
dermatologic molecular diagnostics test menu. Pitfalls of
interpretation and algorithmic approaches to testing are included.
The textbook is directed towards all readers - clinicians,
pathologists, laboratorians, and other inquisitive minds -
independent of their level of molecular expertise, to provoke
thought or perhaps even change practice. The context for the book
is the rapid evolution of the field of molecular diagnostics, which
is becoming more pervasive in all disciplines of medicine,
including dermatology. This is indeed an exciting time in
dermatology. Molecular testing is now incorporated into all aspects
of patient management, including diagnostics (identifying and
classifying disease), prognostics (predicting disease course), and
theranostics (predicting response to therapy). For example,
molecular tests are now used to detect germline mutations that
result in genodermatoses, somatic genetic events that characterize
tumors such as melanoma and sarcomas, and genetic material of
otherwise undetectable infectious organisms. For melanoma and
lymphoma, testing can potentially predict tumor behavior and modify
patient staging. Regarding theranostics, molecular tests that
identify specific mutations in proto- oncogenes, such as BRAF and
others, are now used to predict which patients will respond to
designer targeted therapies. Molecular theranostics has
revolutionized the entire treatment paradigm for patients with
advanced melanoma, repla
The practice of dermatopathology has evolved from viewing
predominantly haematoxylin and eosin (H&E)-stained sections
through the microscope to include an array of more specialized
tests. These are used as stand-alone tests or in addition to the
H&E. Diagnostic Dermatopathology: A Guide to Ancillary Tests
Beyond the H&E is a practical guide to the most important of
these new diagnostic techniques. Aside from a brief review of
H&E in the Introduction, the focus of the book is on the wide
range of more recent ancillary tests commonly used by clinicians,
including sections on special stains, immunohistochemistry,
immunofluorescence, electron microscopy and molecular testing. Each
section describes why each of these tests is performed, how to use
them and how to interpret the results they provide. Abundantly
illustrated with colour photographs, diagrams and algorithms
Diagnostic Dermatopathology: A Guide to Ancillary Tests Beyond the
H&E is packed with practical guidance on commonly-faced
diagnostic dilemmas, how the tests described can be used to resolve
them and how to avoid pitfalls in the diagnostic process. The book
is an essential resource for trainee and practicing
dermatopathologists, dermatologists and pathologists seeking an
accessible guide to the diagnostic methods which are increasingly
important in dermatopathology and which go beyond the H&E.
 Key features Covers the full range of diagnostic tests in
dermatopathology, aside from H&E, with a focus on practical
clinical information such as how to run the test, when to use it
and how to interpret the results Includes special stains,
immunohistochemistry, immunofluorescence, electron microscopy,
molecular testing and point of care tests including potassium
hydroxide preparations, mineral oil preparations, and Tzanck smears
Single author with hand-picked specialist contributors provide a
consistent approach to the subject, replete with diagnostic tips
and clinical advice based on extensive personal experience
|
You may like...
Aladdin
Robin Williams, Scott Weinger, …
Blu-ray disc
R206
Discovery Miles 2 060
|