Disturbances in peripheral O extraction can be produced in dogs treated with 2 endotoxin and thereby provide an opportunity to test theories for the origin of pathological O supply dependency or to try different treatment modalities. The 2 most serious deficiency in the current animal models is the inability to mimic the increased O demand that is observed in patients at 02 delivery rates in excess of 2 normal. A particular feature of this increased O demand is that it apparently does 2 not stimulate increased 02 extraction, although the limitation in O extraction has 2 not been explored in patients by lowering 02 supply, for obvious reasons. At least two possibilities to account for increased 02 demand could be investigated in animal models, however. The amount of 02 that is utilized in extramitochondrial pathways, which is normally on the order of 10%, may be greatly increased in ARDS and sepsis by O radical formation. There is presently no information 2 concerning how much 02 might be used in this way. Another strong possibility is that mitochondrial injury, perhaps as a result of 02 radical formation, uncouples oxidative phosphorylation. Some evidence presently in the literature supports this idea [19]. Indeed, the association of increased blood lactate levels with higher than expected 02 demands makes uncoupling a very attractive hypothesis that warrants further investigation in animal models using such agents as 2,4-dinitrophenol. References 1.

Cuando se abrazan las ciencias, cualquiera sea ella, pero principalmente la investigacion de estas, a nivel analitico y experimental, sabemos que nos encontramos en terreno nuevo y desconocido. Esto suele ser en muchos casos, nuestro principal motor de busqueda. Es asi que el hallazgo y el descubrimiento deben ser una constante necesidad en el trabajo cientifico de todo investigador. Pero todo hallazgo, todo descubrimiento es una violacion a la naturalidad, a lo ya establecido; pero esto nunca debe ser una limitante sino un factor de responsabilidad y compromiso de desarrollar nuestro trabajo cientifico en un contexto etico y optimo, que busque finalmente el mejor desarrollo de la humanidad. Asi la investigacion por medio de la Economia Experimental, proporciona mejores resultados, que cuando se analizaba la masa solamente; ya que precisamente, lo que nos permite un experimento, es poder observar como los sujetos interactuan dentro de entornos estrategicos controlados. Asi en el presente, pretendo mostrar los primeros avances de una de mis teorias "El Azar Economico" asi como de la Competencia Empresarial, que resulta ser mas que lo empirico que se conoce hasta hoy."