Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Histology
|
Buy Now
Tissue Oxygen Utilization (Paperback)
Loot Price: R2,828
Discovery Miles 28 280
|
|
Tissue Oxygen Utilization (Paperback)
Series: Update in Intensive Care and Emergency Medicine, 12
Expected to ship within 10 - 15 working days
|
Disturbances in peripheral O extraction can be produced in dogs
treated with 2 endotoxin and thereby provide an opportunity to test
theories for the origin of pathological O supply dependency or to
try different treatment modalities. The 2 most serious deficiency
in the current animal models is the inability to mimic the
increased O demand that is observed in patients at 02 delivery
rates in excess of 2 normal. A particular feature of this increased
O demand is that it apparently does 2 not stimulate increased 02
extraction, although the limitation in O extraction has 2 not been
explored in patients by lowering 02 supply, for obvious reasons. At
least two possibilities to account for increased 02 demand could be
investigated in animal models, however. The amount of 02 that is
utilized in extramitochondrial pathways, which is normally on the
order of 10%, may be greatly increased in ARDS and sepsis by O
radical formation. There is presently no information 2 concerning
how much 02 might be used in this way. Another strong possibility
is that mitochondrial injury, perhaps as a result of 02 radical
formation, uncouples oxidative phosphorylation. Some evidence
presently in the literature supports this idea [19]. Indeed, the
association of increased blood lactate levels with higher than
expected 02 demands makes uncoupling a very attractive hypothesis
that warrants further investigation in animal models using such
agents as 2,4-dinitrophenol. References 1.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.