Since its first publication in 2007, John H. Arnold's What is Medieval History? has established itself as the leading introduction to the craft of the medieval historian. What is it that medieval historians do? How - and why - do they do it? Arnold discusses the creation of medieval history as a field, the nature of its sources, the intellectual tools used by medievalists, and some key areas of thematic importance from the fall of the Roman Empire to the Reformation. The fascinating case studies include a magical plot against a medieval pope, a fourteenth-century insurrection, and the importance of a kiss exchanged between two tenth-century noblemen. Throughout the book, readers are shown not only what medieval history is, but the cultural and political contexts in which it has been written. This anticipated second edition includes further exploration of the interdisciplinary techniques that can aid medieval historians, such as dialogue with scientists and archaeologists, and addresses some of the challenges - both medieval and modern - of the idea of a 'global middle ages'. What is Medieval History? continues to demonstrate why the pursuit of medieval history is important not only to the present, but to the future. It is an invaluable guide for students, teachers, researchers and interested general readers.

This book describes and analyzes the development assistance programs of the five major European donors: France, Germany, the Netherlands, the United Kingdom, and Sweden. It describes each country's program in terms of the evolution of its philosophy and overall policy goals.

Although much has been written about development assistance to the Third World, nearly all the attention has focused on U.S. programs and policy. The important and growing commitment of European countries--which now collectively account for over half of all development assistance provided by the industrialized nations--has been virtually ignored. European nations, like the u.s., support in principle a aEUROoebasic needsaEURO focus in their assistance programs, but the strategies they employ reveal a variety of styles and technical approaches, many of which could be useful in improving U.S. aid programs. This study describes and analyzes the development assistance programs of the five major European donors: France, Germany, the Netherlands, the United Kingdom, and Sweden. Drawing on primary sources and interviews with representatives of the various assistance agencies and with outside experts, Dr. Arnold describes each country's program in terms of three general areas: the evolution of its philosophy and overall policy goals, the organizational structure of the government institutions concerned with development assistance (including the relationship of these institutions to legislative and other policymaking bodies), and the content and procedures of the assistance programs.

A comprehensive review of the yeast cell envelope has not appeared previously and therefore this book is timely. The title of this volume was chosen to reflect the three major areas of contribution to our current understanding of the cell envelope, but we have not attempted to group chapters into subdivisions. The approach was to describe phenomena, to review the literature and to illuminate outstanding problems. It was also attempted to generate working hypotheses which may stimulate further studies. The some of these ideas be of germinal value is of more concern to us than that all of the hypotheses should stand the test of further experimentation.

A comprehensive review of the yeast cell envelope has not appeared previously and therefore this book is timely. The title of this volume was chosen to reflect the three major areas of contribution to our current understanding of the cell envelope, but we have not attempted to group chapters into subdivisions. The approach was to describe phenomena, to review the literature and to illuminate outstanding problems. It was also attempted to generate working hypotheses which may stimulate further studies. The some of these ideas be of germinal value is of more concern to us than that all of the hypotheses should stand the test of further experimentation.

The question of the reality of Cathars and other heresies is debated in this provocative collection. Cathars have long been regarded as posing the most organised challenge to orthodox Catholicism in the medieval West, even as a "counter-Church" to orthodoxy in southern France and northern Italy. Their beliefs, understood to be inspired by Balkan dualism, are often seen as the most radical among medieval heresies. However, recent work has fiercely challenged this paradigm, arguing instead that "Catharism" is a construct, mis-named and mis-represented by generations of scholars, and its supposedly radical views were a fantastical projection of the fears of orthodox commentators. This volume brings together a wide range of views from some of the most distinguished internationalscholars in the field, in order to address the debate directly while also opening up new areas for research. Focussing on dualism and anti-materialist beliefs in southern France, Italy and the Balkans, it considers a number of crucial issues. These include: what constitutes popular belief; how (and to what extent) societies of the past were based on the persecution of dissidents; and whether heresy can be seen as an invention of orthodoxy. At the same time, the essays shed new light on some key aspects of the political, cultural, religious and economic relationships between the Balkans and more western regions of Europe in the Middle Ages. Antonio Sennis is Senior Lecturer in Medieval History at University College London Contributors: John H. Arnold, Peter Biller, Caterina Bruschi, David d'Avray, Joerg Feuchter, Bernard Hamilton, R.I. Moore, Mark Gregory Pegg, Rebecca Rist, Lucy J. Sackville, Antonio Sennis, Claire Taylor, Julien Thery-Astruc, Yuri Stoyanov

Since its first publication in 2007, John H. Arnold's What is Medieval History? has established itself as the leading introduction to the craft of the medieval historian. What is it that medieval historians do? How - and why - do they do it? Arnold discusses the creation of medieval history as a field, the nature of its sources, the intellectual tools used by medievalists, and some key areas of thematic importance from the fall of the Roman Empire to the Reformation. The fascinating case studies include a magical plot against a medieval pope, a fourteenth-century insurrection, and the importance of a kiss exchanged between two tenth-century noblemen. Throughout the book, readers are shown not only what medieval history is, but the cultural and political contexts in which it has been written. This anticipated second edition includes further exploration of the interdisciplinary techniques that can aid medieval historians, such as dialogue with scientists and archaeologists, and addresses some of the challenges - both medieval and modern - of the idea of a 'global middle ages'. What is Medieval History? continues to demonstrate why the pursuit of medieval history is important not only to the present, but to the future. It is an invaluable guide for students, teachers, researchers and interested general readers.

What is Medieval History? provides an accessible, far-ranging and passionate guide to the study of medieval history. The book discusses the creation of the academic field, the nature of the sources, the intellectual tools used by medievalists, and key areas of thematic importance from the fall of the Roman Empire to the Reformation.

The question of the reality of Cathars and other heresies is debated in this provocative collection. Cathars have long been regarded as posing the most organised challenge to orthodox Catholicism in the medieval West, even as a "counter-Church" to orthodoxy in southern France and northern Italy. Their beliefs, understood to be inspired by Balkan dualism, are often seen as the most radical among medieval heresies. However, recent work has fiercely challenged this paradigm, arguing instead that "Catharism" is a construct, mis-named and mis-represented by generations of scholars, and its supposedly radical views were a fantastical projection of the fears of orthodox commentators. This volume brings together a wide range of views from some of the most distinguished internationalscholars in the field, in order to address the debate directly while also opening up new areas for research. Focussing on dualism and anti-materialist beliefs in southern France, Italy and the Balkans, it considers a number of crucial issues. These include: what constitutes popular belief; how (and to what extent) societies of the past were based on the persecution of dissidents; and whether heresy can be seen as an invention of orthodoxy. At the same time, the essays shed new light on some key aspects of the political, cultural, religious and economic relationships between the Balkans and more western regions of Europe in the Middle Ages. ANTONIO SENNIS is Senior Lecturer in Medieval History at University College London Contributors: John H. Arnold, Peter Biller, Caterina Bruschi, David d'Avray, Joerg Feuchter, Bernard Hamilton, R.I. Moore, Mark Gregory Pegg, Rebecca Rist, Lucy J. Sackville, Antonio Sennis, Claire Taylor, Julien Thery-Astruc, Yuri Stoyanov

Biological systems are very special substrates for engineering-uniquely the products of evolution, they are easily redesigned by similar approaches. A simple algorithm of iterative cycles of diversification and selection, evolution works at all scales, from single molecules to whole ecosystems. In the little more than a decade since the first reported applications of evolutionary design to enzyme engineering, directed evolution has matured to the point where it now represents the centerpiece of industrial biocatalyst development and is being practiced by thousands of academic and industrial scientists in com- nies and universities around the world. The appeal of directed evolution is easy to understand: it is conceptually straightforward, it can be practiced without any special instrumentation and, most important, it frequently yields useful solutions, many of which are totally unanticipated. Directed evolution has r- dered protein engineering readily accessible to a broad audience of scientists and engineers who wish to tailor a myriad of protein properties, including th- mal and solvent stability, enzyme selectivity, specific activity, protease s- ceptibility, allosteric control of protein function, ligand binding, transcriptional activation, and solubility. Furthermore, the range of applications has expanded to the engineering of more complex functions such as those performed by m- tiple proteins acting in concert (in biosynthetic pathways) or as part of mac- molecular complexes and biological networks.

Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum "you get what you screen for. " The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.

Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum "you get what you screen for. " The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.

Biological systems are very special substrates for engineering-uniquely the products of evolution, they are easily redesigned by similar approaches. A simple algorithm of iterative cycles of diversification and selection, evolution works at all scales, from single molecules to whole ecosystems. In the little more than a decade since the first reported applications of evolutionary design to enzyme engineering, directed evolution has matured to the point where it now represents the centerpiece of industrial biocatalyst development and is being practiced by thousands of academic and industrial scientists in com- nies and universities around the world. The appeal of directed evolution is easy to understand: it is conceptually straightforward, it can be practiced without any special instrumentation and, most important, it frequently yields useful solutions, many of which are totally unanticipated. Directed evolution has r- dered protein engineering readily accessible to a broad audience of scientists and engineers who wish to tailor a myriad of protein properties, including th- mal and solvent stability, enzyme selectivity, specific activity, protease s- ceptibility, allosteric control of protein function, ligand binding, transcriptional activation, and solubility. Furthermore, the range of applications has expanded to the engineering of more complex functions such as those performed by m- tiple proteins acting in concert (in biosynthetic pathways) or as part of mac- molecular complexes and biological networks.

The fourteenth century was, for the English, a century which witnessed dramatic and not always easily explicable changes of fortune. In 1300, England's population was around seven million, and Edward I seemed to be on the verge of turning the British Isles into an English Empire. By 1400, its population was between three and four million (due mainly to the Black Death), dreams of a 'British' empire had all but crumbled, and instead England had become embroiled in a war - the Hundred Years' War - which was not only ultimately disastrous, but which also established the French as the 'national enemy' for many centuries to come. In addition, despite the fact that before 1300 no reigning English monarch had ever been deposed, by 1400 two had: Edward II in 1327, and Richard II in 1399. Sandwiched between these two turbulent reigns, however, came that of Edward III, one of the most successful, both politically and militarily, in English history. It is against the background of these remarkable fluctuations that the articles in this volume, the second in the Fourteenth Century England series, have been written. The range of subjects which they cover is wide: from princely education to popular heresy, from national propaganda to the familial and territorial power politics which occasioned the downfall of kings. Taken together, they reinforce the view that, whether viewed as calamitous or heroic, the fourteenth century was never less than interesting.CHRIS GIVEN-WILSON is Professor of Late Medieval History, University of St Andrews. Contributors: MARTIN ALLEN, JOHN ARNOLD, PAULETTE BARTON, TOM BEAUMONT-JAMES, ALASTAIR DUNN, JEFFREY HAMILTON, JILL C. HAVENS, ANDY KING, CARLA LORD, SHELAGHMITCHELL, MICHAEL PRESTWICH, ARND REITMEIER, NIGEL SAUL.

Die lahrestagung der Deutschen Gesellschaft fUr Hiimatologie fand im Oktober 1976 nach 21 lahren zum erstenmal wieder in Freiburg statt. 1955 war der KongreBprasident unser unvergessener Ludwig Heitmeyer, der besonders auf dem Gebiete des Eisenstoffwechsels maBgebliche methodische und klinische Pionierarbeit geleistet hat. Die 3 Hauptthemen dieser Tagung sind daher teilweise durch den "genius loci" mitbestimmt (Abb. 1). Abb.1. Ludwig Heilmeyer, 1899-1969 Der Eisenstoffwechsel ist schon seit der Frtihgeschichte ein Problem der Menschheit, dessen Storungen die haufigste Ursache fUr Bluterkrankungen darstellt. Die Phylogenese vom A vertebraten tiber die Vertebraten zum Men- schen ware ohne das Auftreten des eisenhaltigen Hamoglobinmolekiils gar nicht moglich gewesen, schaffte es doch die Voraussetzung der reversiblen Oxygena- tion und damit der zahlreichen Redox-Reaktionen aller einfachen und kompli- zierten Gewebe und Korperorgane. Das so einfach erscheinende Eisenatom kommt in zwei-und dreiwertiger Form vor. Das_zweiwertige Eisen hat an seiner AuBenschale nur 6 d-Elektronen, das dreiwertige Eisen-Ion 5 d-Elektronen. Beide Eisenformen haben gewohnlich eine oktahedrale Koordination, wie aus der Abb. 2 hervorgeht. Vorwort x L, k-_____ -+------::::::==---::~L, L, '"'--=-----+----'~ Abb. 2. Modell des Eisenatoms L, In dieser Form ist das zentrale Metall-Ion umgeben durch vier Liganden-Ato- me LI-L4 an den Ecken des Vierecks und hat auBerdem zwei zusatzliche Liganden-Atome L5 und L6.

Historiographical survey of inquisition texts, from lists of questions to inquisitor's manual, studies their role in the suppression of heresy. Did you see a heretic? When? Where? Who else was there?'. The inquisitor is questioning, and a suspect is replying; a notary is translating from the vernacular into Latin, and writing it down, abbreviating and omitting at will; later there is the reading out of a sentence in public and then, in a few cases, burning. At every stage there is a text: a list of questions, for example, or an inquisitor's how-to-do it manual. The substance and intention of these texts forms the subject of this book. The introduction brings them all together in an historiographical survey of the role of texts in the suppression of heresy, and the volume is crowned by the Quodlibet lecture, in which the doyen of all heresy historians, ALEXANDER PATSCHOVSKY, magisterially surveys the political nature of heresy accusations. Contributors: MARK PEGG, PETER BILLER, CATERINA BRUSCHI, JAMES GIVEN, JOHN ARNOLD, JESSALYN BIRD, ANNE HUDSON, ALEXANDER PATSCHOVSKY.

Heresy and inquisition in France, 1200-1300 is an invaluable collection of primary sources in translation, aimed at students and academics alike. It provides a wide array of materials on both heresy (Cathars and Waldensians) and the persecution of heresy in medieval France. The book is divided into eight sections, each devoted to a different genre of source material. It contains substantial material pertaining to the setting up and practice of inquisitions into heretical wickedness, and a large number of translations from the registers of inquisition trials. Each source is introduced fully and is accompanied by references to useful modern commentaries. The study of heresy and inquisition has always aroused considerable scholarly debate; with this book, students and scholars can form their own interpretations of the key issues, from the texts written in the period itself. -- .

Eleanor's secret love for Chad could mean losing her inheritance and giving up a life long dream. Will she follow her own will, or make the hard choice to submit her life to Christ's leadership? Now available with a contemporary new look, Not My Will is a classic story of love, loss, and surrender, with more than 500,000 copies sold.

John Arnold's Very Short Introduction is a stimulating essay about how we study and understand history. The book begins by inviting us to think about various questions provoked by our investigation of history, and explores the ways these questions have been answered in the past. Concepts such as causation, interpretation, and periodization, are introduced by means of concrete examples of how historians work, giving the reader a sense of the excitement of discovering not only the past, but also ourselves.

Margery Kempe and her Book studied in both literary and historical context. Margery Kempe's Book provides rare access to the "marginal voice" of a lay medieval woman, and is now the focus of much critical study. This Companion seeks to complement the existing almost exclusively literary scholarship with work that also draws significantly on historical analysis, and is concerned to contextualise Kempe's Book in a number of different ways, using her work as a way in to the culture and society of medieval northern Europe. Topics include images and pilgrimage; women, work and trade in medieval Norfolk; political culture and heresy; the prophetic tradition; female mystics and the body; women's roles and lifecycle; religious drama and reenactment; autobiography and gender. Contributors: JOHN H. ARNOLD, P.H. CULLUM, ISABEL DAVIS, ALLYSON FOSTER, JACQUELINE JENKINS, KATHERINE J. LEWIS, KATE PARKER, KIM M. PHILLIPS, SARAH SALIH, CLAIRE SPONSLER, DIANE WATT,BARRY WINDEATT.

Inquisition and Power Catharism and the Confessing Subject in Medieval Languedoc John H. Arnold "Intelligent and demanding."--"Religious Studies Review" "The lasting importance of Arnold's book is that . . . it will provoke scholars to rethink what they thought they knew about heresy, confession, and the inquisition in the Middle Ages."--"Speculum" "Intelligent and demanding. . . . The persevering reader will be amply rewarded by many insights into the nature of the Inquisition, Catharism, and elitist construction of confession, conformity, and subjectivity."--"Religious Studies Review" "Arnold has written an innovative, challenging, and stimulating book."--James Given, University of California, Irvine "Arnold has contributed to raising important questions of methodology, enriching a recently rediscovered debate on the reliability of sources about the repression of heresy in the late Middle Ages."--"Journal of Ecclesiastical History" What should historians do with the words of the dead? "Inquisition and Power" reformulates the historiography of heresy and the inquisition by focusing on depositions taken from the Cathars, a religious sect that opposed the Catholic church and took root in southern France during the twelfth century. Despite the fact that these depositions were spoken in the vernacular, but recorded in Latin in the third person and rewritten in the past tense, historians have often taken these accounts as verbatim transcriptions of personal testimony. This belief has prompted some historians, including E. Le Roy Ladurie, to go so far as to retranslate the testimonies into the first-person. These testimonies have been a long source of controversy for historians and scholars of the Middle Ages. Arnold enters current theoretical debates about subjectivity and the nature of power to develop reading strategies that will permit a more nuanced reinterpretation of these documents of interrogation. Rather than seeking to recover the true voice of the Cathars from behind the inquisitor's framework, this book shows how the historian is better served by analyzing texts as sites of competing discourses that construct and position a variety of subjectivities. In this critically informed history, Arnold suggests that what we do with the voices of history in fact has as much to do with ourselves as with those we seek to 'rescue' from the silences of past. John H. Arnold is Lecturer in History at the University of East Anglia. The Middle Ages Series 2001 328 pages 6 1/8 x 9 1/4 ISBN 978-0-8122-3618-7 Cloth $75.00s 49.00 ISBN 978-0-8122-0116-1 Ebook $75.00s 49.00 World Rights History, Religion

Heresy and inquisition in France, 1200-1300 is an invaluable collection of primary sources in translation, aimed at students and academics alike. It provides a wide array of materials on both heresy (Cathars and Waldensians) and the persecution of heresy in medieval France. The book is divided into eight sections, each devoted to a different genre of source material. It contains substantial material pertaining to the setting up and practice of inquisitions into heretical wickedness, and a large number of translations from the registers of inquisition trials. Each source is introduced fully and is accompanied by references to useful modern commentaries. The study of heresy and inquisition has always aroused considerable scholarly debate; with this book, students and scholars can form their own interpretations of the key issues, from the texts written in the period itself. -- .

For most people in the middle ages--for thousands upon thousands who lived within Christendom in the period considered by this book, 1100-1500--we have no record of what they believed or did not believe. John Arnold sifts through the traces left behind by our ancestors across Europe and assembles a more complete picture than ever before. Religion in mediveal Europe was hugely important, and impinged upon the most mundane aspects of everyday life. But was the period a uniform "Age of Faith?" By focussing on lay people, this fascinating account unlocks the multiple meanings of religion, asking how it functioned and with what effects.
This book deftly reveals for today's readers, as none have before, the meanings and struggles that lay between the smooth surface of medieval religious life.

A. Die Zielsetzung des Buches. Die mathematische Logik, die hinsichtlich ihrer Methode als Mathe- matik, hinsichtlich ihres Gegenstandes als Logik anzusprechen ist, stellt sich als eines jener Wissensgebiete dar, auf denen sich gegenwartig die ur- sprunglichen Interessen der Mathematiker und der nicht originar mathe- matisch orientierten Geisteswissenschaftler uberschneiden. Die Gesetz- maBigkeit des Denkens hat sich in weitem MaBe als eine so1che von der Art mathematischer GesetzmaBigkeiten enthlillt, und keine Logik kann an diesem Tatbestand mehr vorbeigehen, so wie heute etwa keine Physik mehr den analogen Tatbestand ignoriert. Das vorliegende Buch will sich demgemaB - wie die ihm zugrunde liegenden mehrfach gehaltenen Vorlesungen es wollten - zunachst an Mathematiker, zugleich aber auch an mathematisch interessierte Nicht- mathematiker - hiervor allem eben: an geisteswissenschaftlich orien- tierte Logiker - wenden. Diesem Ausgangsimpuls entspringt eine doppelte Zielsetzung. Einerseits will das Buch - im Gegensatz zu bloBen Anfangerbuchem - in jedem angeschnittenen Problemkreis bis zu seinen zentralen Fragestellungen vordringen und sie in exakter mathematischer Behandlungsweise beantworten. Andererseits solI es jedoch gleichzeitig mathematisch ausgebildeten Lesem das Instrumen- den nebenfachlich tarium, das zum vollen Erfassen des mathematischen Gehaltes des Stoffes natig ist, in die Hand geben.