This book is a review of studies on the physiopharmacology of the peripheral fibres involved in nociception. It examines the substances that are directly or indirectly capable of modifying the activity of these fibres, paying special attention to the part played by physicochemical factors and the sympathetic nervous system. Drawing on the conclusions of eminent pharmacologists, the book not only considers fundamental aspects of the problem but also suggests approaches for research into developing new analgesic molecules. It will be of interest to researchers, pharmacologists, physiologists, physicians and the pharmaceutical industry.

Our knowledge of the brain and its structures -- such as the thalamus, hypothalamus and cortex -- has made great strides over the past 15 years. As in other fields, this progress has been due to studies based on a multidisciplinary approach combining modern and traditional investigative methods. The new knowledge has highlighted the part played by some fundamental structures in pain processing. This book reviews the data that has been acquired and the new perspectives it has opened up for studying how the brain processes pain, in both humans and animals. For neurologists, neurobiologists and neurosurgeons.