Meta-analysis is the application of statistics to combine results from multiple studies and draw appropriate inferences. Its use and importance have exploded over the last 25 years as the need for a robust evidence base has become clear in many scientific areas, including medicine and health, social sciences, education, psychology, ecology, and economics. Recent years have seen an explosion of methods for handling complexities in meta-analysis, including explained and unexplained heterogeneity between studies, publication bias, and sparse data. At the same time, meta-analysis has been extended beyond simple two-group comparisons of continuous and binary outcomes to comparing and ranking the outcomes from multiple groups, to complex observational studies, to assessing heterogeneity of effects, and to survival and multivariate outcomes. Many of these methods are statistically complex and are tailored to specific types of data. Key features Rigorous coverage of the full range of current statistical methodology used in meta-analysis Comprehensive, coherent, and unified overview of the statistical foundations behind meta-analysis Detailed description of the primary methods for both univariate and multivariate data Computer code to reproduce examples in chapters Thorough review of the literature with thousands of references Applications to specific types of biomedical and social science data Supplementary website with code, data, sample chapters, and errata This book is for a broad audience of graduate students, researchers, and practitioners interested in the theory and application of statistical methods for meta-analysis. It is written at the level of graduate courses in statistics, but will be of interest to and readable for quantitative scientists from a range of disciplines. The book can be used as a graduate level textbook, as a general reference for methods, or as an introduction to specialized topics using state-of-the art methods.

Meta-analysis is the application of statistics to combine results from multiple studies and draw appropriate inferences. Its use and importance have exploded over the last 25 years as the need for a robust evidence base has become clear in many scientific areas, including medicine and health, social sciences, education, psychology, ecology, and economics. Recent years have seen an explosion of methods for handling complexities in meta-analysis, including explained and unexplained heterogeneity between studies, publication bias, and sparse data. At the same time, meta-analysis has been extended beyond simple two-group comparisons of continuous and binary outcomes to comparing and ranking the outcomes from multiple groups, to complex observational studies, to assessing heterogeneity of effects, and to survival and multivariate outcomes. Many of these methods are statistically complex and are tailored to specific types of data. Key features Rigorous coverage of the full range of current statistical methodology used in meta-analysis Comprehensive, coherent, and unified overview of the statistical foundations behind meta-analysis Detailed description of the primary methods for both univariate and multivariate data Computer code to reproduce examples in chapters Thorough review of the literature with thousands of references Applications to specific types of biomedical and social science data Supplementary website with code, data, sample chapters, and errata This book is for a broad audience of graduate students, researchers, and practitioners interested in the theory and application of statistical methods for meta-analysis. It is written at the level of graduate courses in statistics, but will be of interest to and readable for quantitative scientists from a range of disciplines. The book can be used as a graduate level textbook, as a general reference for methods, or as an introduction to specialized topics using state-of-the art methods.

The properties of proteins are determined not only by the sequence of amino-acid residues in the polypeptide chains, but also by the con- figuration of the chains-the way in which the chains are coiled or folded. It is probable that denaturation, the loss of some of the specific properties of a native protein, may in many cases be the result simply of a change in configuration of the polypeptide chains, without any change whatever in the sequence of amino-acid residues. During the past few years great progress has been made in the attack on the determination of the sequence of amino-acid residues in the poly- peptide chains of proteins, through the work of SANGER and his collabora- tors (Io9, IIO) and of other investigators. There has also been significant progress in the attack on the problem of the configuration of polypeptide chains, largely through the application of the X-ray diffraction technique.

Dieser Band, der zeitlich als erster erscheint, enthalt die Katalyse in Losungen. Ihm sollen in kurzester Zeit Band I (Allgemeines und Gaskatalyse) und Band III (Biokatalyse) folgen, so dass dann all s, was etwa den reinen Chemiker, den Biologen und viele Praktiker interessieren durfte, fertig vorliegt. Es waren hauptsachlich drei Fragenkreise, die bei der Zusammenstellung dieses Bandes zu beachten waren: die katalytische Rolle des Mediums selbst zunachst. Hier erfordert die Erforschung der nichtwassrigen Losungen, wie man sehen wird, noch viel Entwicklungsar. beit, wahrend die Salzeffekte in wassriger Losung im wesentlichen aufgeklart sind. Dies ist wichtige Voraussetzung fur den zweiten grosseQ Fragenkreis, die Saure-Basen-Katalyse, die jetzt endlich auf dieser Grundlage eine ganz geschlossene kritische Darstellung finden konnte, wie sie den Kenner der bisherigen Sachlage befriedigen wird. Es erschien wichtig, hier nicht nur den Kinetiker, sondern auch den Organiker zu Wort kommen zu lassen, nachdem besonders die englische Schule auf Grund einer weitgehenden Sichtung des Tatsachenmaterials zu allgemeineren und mit der Kinetik uberein stimmenden Gesichtspunkten gelangt ist. Der dritte grosse Fragenkomplex sind die Vorgange der Oxydation und besonders Autoxydation und ihrer Hemmung. Hier bringt das Handbuch an Stelle eines heute notwendig noch unvollstandigen kinetischen einen mehr chemisch orientierten Artikel, der alle einschlagigen Ge sichtspunkte berucksichtigt. Die Liste der Verfasser zeigt wohl ohne weiteres an, dass die Fertigstellung der eingegangenen Beitrage zeitgebundene Schwierigkeiten zu uberwinden hatte."

This is an EXACT reproduction of a book published before 1923. This IS NOT an OCRd book with strange characters, introduced typographical errors, and jumbled words. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

Die Konigsbucher schildern die Epoche des Konigtums von der Thronbesteigung Davids bis zum Ende des Konigtums in Juda zur Zeit der Eroberung Jerusalems durch die Babylonier. Der namentlich nicht bekannte Verfasser, in der heutigen Forschung als deuteronomistischer Historiker bezeichnet, hat fur diesen Teil der israelitischen Geschichte Quellen ausgewertet und Aufzeichnungen gemacht, die zahlreiche Einzelheiten der Konigszeit dokumentieren. Hauptzweck dieser Geschichtsschreibung ist es aber, den Untergang des Konigtums in Juda und Israel als Folge menschlichen Fehlverhaltens zu erklaren. In diesem Sinn bietet der Kommentar nicht nur die notige Klarung von Sachfragen, sondern zeigt die theologischen Bezuge des Geschichtswerks und die Absichten seines Verfassers. Dabei fuhrt der Weg von der glanzvollen Zeit unter Salomo immer weiter ins Verderben bis zum Ende der staatlichen Selbstandigkeit verbunden mit der Abschaffung des Konigtums durch die Babylonier und Assyrer.