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The objectives of this work is comparing three different kinds of
sulfonamide compounds by evaluating structure modification through
their examination towards more important properties such as: (a)
Surface properties of the synthesized sulfonamide compounds were
studied through surface parameters cmc, (cmc), A(min) and (max).
Most of these tested compounds have remarkable surface activity.
(b) The target compounds were tested to determine
structure-biological activity relationship against different types
of pathogenic bacterial species. The amine acid salts of bis
(2-aminophenyl) biphenyl-4,4'-disulfonamide (Series B) were the
powerfully effective series. Only carboxylic acid salts of bis
(2-aminophenyl)biphenyl-4,4'- disulfonamide (Series B) were
powerfully effective series against selected pathogenic fungal
species. (c) Selected compounds were screened for cytotoxicity
against selected human tumor cell lines - MCF7, HEPG2, and HCT116.
Most of tested compounds have potent cytotoxic activity against
liver carcinoma and colon carcinoma, meanwhile, exhibit moderate
activity against breast carcinoma."
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