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Calcium plays an important role in a wide variety of biological
processes. This divalent metal ion can bind to a large number of
proteins; by doing so it modifies their biological activity or
their stability. Because of its distinct che- cal properties
calcium is uniquely suited to act as an on-off switch or as a light
dimmer of biological activities. The two books entitled
Calcium-Binding Protein Protocols (Volumes I and II) focus on
modern experimental analyses and methodologies for the study of
calcium-binding proteins. Both extracel- lar and intracellular
calcium-binding proteins are discussed in detail. H- ever, proteins
involved in calcium handling (e. g. , calcium pumps and calcium
channels), fall outside of the scope of these two volumes. Also,
calcium-bi- ing proteins involved in bone deposition will not be
discussed, as this specific topic has been addressed previously.
The focus of these two books is on studies of the calcium-binding
proteins and their behavior in vitro and in vivo. The primary
emphasis is on protein chemistry and biophysical methods. Many of
the methods described will also be applicable to proteins that do
not bind calcium. Calcium-Binding Protein Protocols is divided into
three main sections. The section entitled Introduction and Reviews
provides information on the role of calcium in intracellular
secondary messenger activation mechanisms. Mo- over, unique aspects
of calcium chemistry and the utilization of calcium in dairy
proteins, as well as calcium-binding proteins involved in blood
clotting, are addressed.
Calcium plays an important role in a wide variety of biological
processes. This divalent metal ion can bind to a large number of
proteins; by doing so it modifies their biological activity or
their stability. Because of its distinct che- cal properties
calcium is uniquely suited to act as an on-off switch or as a light
dimmer of biological activities. The two books entitled
Calcium-Binding Protein Protocols (Volumes I and II) focus on
modern experimental analyses and methodologies for the study of
calcium-binding proteins. Both extracel- lar and intracellular
calcium-binding proteins are discussed in detail. H- ever, proteins
involved in calcium handling (e. g. , calcium pumps and calcium
channels), fall outside of the scope of these two volumes. Also,
calcium-bi- ing proteins involved in bone deposition will not be
discussed, as this specific topic has been addressed previously.
The focus of these two books is on studies of the calcium-binding
proteins and their behavior in vitro and in vivo. The primary
emphasis is on protein chemistry and biophysical methods. Many of
the methods described will also be applicable to proteins that do
not bind calcium. Calcium-Binding Protein Protocols is divided into
three main sections. The section entitled Introduction and Reviews
provides information on the role of calcium in intracellular
secondary messenger activation mechanisms. Mo- over, unique aspects
of calcium chemistry and the utilization of calcium in dairy
proteins, as well as calcium-binding proteins involved in blood
clotting, are addressed.
Blurb for Volume 2
Hans Vogel and a panel of leading researchers review the protein
chemistry and behavior of this significant class proteins, and
provide a comprehensive collection of proven experimental
techniques for studying it both in vitro and in vivo. This second
volume focuses on cutting-edge experimental techniques for studying
the solution structure, stability, dynamics, calcium-binding
properties, and biological activity of calcium-binding protein in
general. In addition to enzymatic assays and more routine
spectroscopic and protein chemistry techniques, there are also NMR
approaches, thermodynamic analyses, kinetic measurements such as
surface plasmon resonance, strategies for amino acid sequence
alignments, and fluorescence methods to study the distribution of
calcium and calcium-binding proteins in cells. The first companion
volume, Reviews and Case Histories sets the stage for this volume
by introducing the various classes of intra- and extra-cellular
calcium-binding proteins and their mode of action.
Single Blurb for Both Volumes
Hans Vogel and a panel of leading researchers review the protein
chemistry and behavior of this significant protein class, and
provide a comprehensive collection of proven experimental
techniques for their study both in vitro and in vivo. The first
volume discusses the role of calcium in intracellular secondary
messenger activation mechanisms, including unique aspects of
calcium chemistry and its utilization in dairy proteins and blood
clotting. Detailed case studies provide a wealth of valuable
information about protein purification and characterization
strategies, X-ray crystallography, and specific calcium-binding
proteins andtheir modes of action. The second volume focuses on
cutting-edge experimental techniques for studying the solution
structure, stability, dynamics, calcium-binding properties, and
biological activity of calcium-binding protein in general. In
addition to enzymatic assays and more routine spectroscopic and
protein chemistry techniques, there are also NMR approaches,
thermodynamic analyses, kinetic measurements such as surface
plasmon resonance, strategies for amino acid sequence alignments,
and fluorescence methods to study the distribution of calcium and
calcium-binding proteins in cells.
Blurb for Volume 1
Hans Vogel and a panel of leading researchers review the protein
chemistry and behavior of this significant protein class, and
provide a comprehensive collection of proven experimental
techniques for their study both in vitro and in vivo. This first
volume discusses the role of calcium in intracellular secondary
messenger activation mechanisms, including unique aspects of
calcium chemistry and its utilization in diary proteins and blood
clotting. Detailed case studies provide a wealth of valuable
information about protein purification and characterization
strategies, X-ray crystallography, and specific calcium-binding
proteins and their modes of action. The second companion volume
focuses on cutting-edge experimental methods for studying solution
structure, stability, dynamics, calcium-binding properties, and
biological activity of calcium-binding proteins in general.
Single Blurb for Both Volumes:
Hans Vogel and a panel of leading researchers review the protein
chemistry and behavior of this significant protein class, and
provide a comprehensive collection of proven experimental
techniques for their study both in vitro and in vivo. The first
volume discusses the role of calcium in intracellular secondary
messenger activation mechanisms, including unique aspects of
calcium chemistry and its utilization in dairy proteins and blood
clotting. Detailed case studies provide a wealth of valuable
information about protein purification and characterization
strategies, X-ray crystallography, and specific calcium-binding
proteins and their modes of action. The second volume focuses on
cutting-edge experimental techniques for studying the solution
structure, stability, dynamics, calcium-binding properties, and
biological activity of calcium-binding protein in general. In
addition to enzymatic assays and more routine spectroscopic and
protein chemistry techniques, there are also NMR approaches,
thermodynamic analyses, kinetic measurements such as surface
plasmon resonance, strategies for amino acid sequence alignments,
and fluorescence methods to study the distribution of calcium and
calcium-binding proteins in cells.
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