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The applications of nanoparticulate drug delivery have gained
significant attention in cancer diagnosis and treatment. Owing to
their unique features and design, nanomedicines have made
remarkable progress in eliminating dreadful tumors. Research in
cancer nanomedicine spans multitudes of drug-delivery systems that
include high tumor-targeting ability, sensitivity toward tumor
microenvironments, and improved efficacy. Various nanocarriers have
been developed and approved for anti-tumor drug targeting. These
nanocarriers, such as liposomes, micelles, nanotubes, dendrimers,
and peptides, offer several advantages including high selectivity,
multifunctionality, specificity, biocompatibility, and precise
control of drug release. This book provides complete information
about each aspect of nanomaterials and nanotherapeutics, including
synthesis, analysis, disease diagnosis, mechanistic insight,
targeted drug delivery, and clinical implications in a concise and
informative way. It presents simple and reader-friendly
representations of the mechanisms of action of nanomaterials on
cellular targets and highlights the challenges in targeted drug
delivery with ongoing chemotherapeutic drugs.
This new volume familiarizes readers with the very relevant
concepts of human resources and finance in Industry 4.0. The book
looks at the adoption of current fast-moving computers and
automation in the workplace and its impact on the financial aspects
of human resources and how HR can be enhanced with smart and
autonomous systems fueled by data and machine learning. The
chapters offer case studies that provide firsthand knowledge of
real-life problems, solutions, and situations faced by the
industry. The volume highlights the thought process in resolution
of the complex problems. Topics include HR management approaches,
global HR challenges, behavioral finance for financial acumen,
corporate social responsibility, women empowerment in the HR
industry, emotional intelligence in the era of Industry 4.0, and
more.
Exploring the issue of Islamophobic attacks against Sikhs since
9/11, this book explains the historical, religious and legal
foundations and frameworks for understanding race hate crime
against the Sikh community in the UK. Focusing on the backlash that
Sikhs in the UK have faced since 9/11, the authors provide a
theological and historical backdrop to Sikh identity in the global
context, critically analysing the occurrences of Islamophobia since
9/11, 7/7 and most recently post-Brexit, and how British Sikhs and
the British government have responded and reacted to these
incidents. The experiences of American Sikhs are also explored and
the impact of anti-Sikh sentiment upon both these communities is
considered. Drawing on media reporting, government policies, the
emerging body of inter-disciplinary scholarship, and empirical
research, this book contributes to the currently limited body of
literature on anti-Sikh hate crime and produces ideas for policy
makers on how to rectify the situation. Providing a better
understanding of perceptions of anti-Sikh sentiment and its impact,
this book will of interest to scholars and upper-level students
working on identity and hate crime, and more generally in the
fields of Religion and Politics, Cultural Studies, Media Studies,
and International Studies.
This important volume provide a one-stop resource on the SAFER
Guides along with the guides themselves and information on their
use, development, and evaluation. The Safety Assurance Factors for
EHR Resilience (SAFER) guides, developed by the editors of this
book, identify recommended practices to optimize the safety and
safe use of electronic health records (EHRs). These guides are
designed to help organizations self-assess the safety and
effectiveness of their EHR implementations, identify specific areas
of vulnerability, and change their cultures and practices to
mitigate risks. This book provides EHR designers, developers,
implementers, users, and policymakers with the requisite historical
context, clinical informatics knowledge, and real-world, practical
guidance to enable them to utilize the SAFER Guides to proactively
assess the safety and effectiveness of their electronic health
records EHR implementations. The first five chapters are designed
to provide readers with the conceptual knowledge required to
understand why and how the guides were developed. The next nine
chapters focus on the underlying informatics concepts, key research
activities, and methods used to develop each of the guides. Each of
these chapters concludes with a copy of the guide itself. The final
chapter provides a vision for the future and the work required to
ensure that future generations of EHRs are designed, developed,
implemented, and used to improve the overall safety of the
EHR-enabled healthcare system. Taken together, the information
provided in this book should help any organization, whether large
or small, implement its EHR program and improve the safety and
effectiveness of its existing EHR-enabled healthcare systems. This
volume will be extremely valuable to small, ambulatory physician
practices and larger outpatient settings as well as for hospitals
and professors and instructors charged with teaching safe and
effective implementation and use of EHRs. It will also be highly
useful for health information technology professionals responsible
for maintaining a safe and effective EHR and for clinical and
administrative staff working in EHR-enabled healthcare systems.
Exploring the issue of Islamophobic attacks against Sikhs since
9/11, this book explains the historical, religious and legal
foundations and frameworks for understanding race hate crime
against the Sikh community in the UK. Focusing on the backlash that
Sikhs in the UK have faced since 9/11, the authors provide a
theological and historical backdrop to Sikh identity in the global
context, critically analysing the occurrences of Islamophobia since
9/11, 7/7 and most recently post-Brexit, and how British Sikhs and
the British government have responded and reacted to these
incidents. The experiences of American Sikhs are also explored and
the impact of anti-Sikh sentiment upon both these communities is
considered. Drawing on media reporting, government policies, the
emerging body of inter-disciplinary scholarship, and empirical
research, this book contributes to the currently limited body of
literature on anti-Sikh hate crime and produces ideas for policy
makers on how to rectify the situation. Providing a better
understanding of perceptions of anti-Sikh sentiment and its impact,
this book will of interest to scholars and upper-level students
working on identity and hate crime, and more generally in the
fields of Religion and Politics, Cultural Studies, Media Studies,
and International Studies.
This book describes translational cancer therapeutics and the way
forward from clinical and molecular diagnosis to treatment. In
addition, genomics alterations, microRNAs, and long non-coding RNAs
translate precision medicine for the individualistic therapy of
cancer patients. It describes the involvement of various
pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK)
modulations of medicines. Indeed, the role of bioinformatics and
biostatistics, considering the extensive data analysis serving
precision medicine approaches, has also been entertained in the
present book. Therefore, intended book demonstrates the successful
medical evidence for the use of precision medicine in the treatment
of cancer and its future clinical perspectives. It fills the gaps
in cancer biology and precision medicine with its up-to-date
content and well-designed chapters. It will serve as a valuable
resource for science, medical students, and interdisciplinary
researchers. It is a very welcome addition for the scientific
community, research centers, and university-industry research
collaborators to find out a complete capsular package about cancer
drug targets, precision, and personalized medicine (including an
introduction to cancer cell signaling, genomic alterations, miRNA
targeting, pharmacogenetics, biomarkers, and metabolomics in
precision medicine, etc.) at a single platform.
This book explores potential cellular drug targets for cancer
therapy. The first couple of chapters describe conventional
treatment (radiotherapy, chemotherapy, and immunotherapy) &
detection (biosensors) strategies for cancer. In contrast, the
subsequent chapters address the role of cyclin-dependent kinases
and cell cycle regulatory proteins in the growth of cancer cells
and their potential as target for cancer treatment. The book then
discusses the regulation of various pro-apoptotic and
anti-apoptotic proteins via chemotherapeutic drugs. In addition, it
examines the molecular mechanisms that are critical for mediating
autophagic cell death in cancer cells. It subsequently reviews the
role of reactive oxygen (ROS) species during carcinogenesis and
during chemotherapy, and the potential of anti-inflammatory routes
for the development of new therapeutic modulators. Lastly, it
describes therapeutic strategies that target the tumor
microenvironment and various angiogenic pathways for the treatment
of cancer and to develop personalized medicine. Given its scope,
the book is valuable resource for oncologists, cancer researchers,
clinicians, and pharmaceutical industry personnel.
This new volume familiarizes readers with the very relevant
concepts of human resources and finance in Industry 4.0. The book
looks at the adoption of current fast-moving computers and
automation in the workplace and its impact on the financial aspects
of human resources and how HR can be enhanced with smart and
autonomous systems fueled by data and machine learning. The
chapters offer case studies that provide firsthand knowledge of
real-life problems, solutions, and situations faced by the
industry. The volume highlights the thought process in resolution
of the complex problems. Topics include HR management approaches,
global HR challenges, behavioral finance for financial acumen,
corporate social responsibility, women empowerment in the HR
industry, emotional intelligence in the era of Industry 4.0, and
more.
Despite diagnosis being the key feature of a physician's clinical
performance, this is the first book that deals specifically with
the topic. In recent years, however, considerable interest has been
shown in this area and significant developments have occurred in
two main areas: a) an awareness and increasing understanding of the
critical role of clinical decision making in the process of
diagnosis, and of the multiple factors that impact it, and b) a
similar appreciation of the role of the healthcare system in
supporting clinicians in their efforts to make accurate diagnoses.
Although medicine has seen major gains in knowledge and technology
over the last few decades, there is a consensus that the diagnostic
failure rate remains in the order of 10-15%. This book provides an
overview of the major issues in this area, in particular focusing
on where the diagnostic process fails, and where improvements might
be made.
Despite diagnosis being the key feature of a physician's clinical
performance, this is the first book that deals specifically with
the topic. In recent years, however, considerable interest has been
shown in this area and significant developments have occurred in
two main areas: a) an awareness and increasing understanding of the
critical role of clinical decision making in the process of
diagnosis, and of the multiple factors that impact it, and b) a
similar appreciation of the role of the healthcare system in
supporting clinicians in their efforts to make accurate diagnoses.
Although medicine has seen major gains in knowledge and technology
over the last few decades, there is a consensus that the diagnostic
failure rate remains in the order of 10-15%. This book provides an
overview of the major issues in this area, in particular focusing
on where the diagnostic process fails, and where improvements might
be made.
As a boy, Hardeep Singh Kohli knew where home was: Glasgow. But
everyone else always assumed he was Indian. Because surely he
couldn't be British, with his brown skin and turban? Thirty years
later, Hardeep sets out on a journey to discover where he is really
from. His story is as hilarious as it is moving.
Due to the role of software systems in safety-critical applications
and in the satisfaction of customers and organizations, the
development of efficient software engineering is essential.
Designing, Engineering, and Analyzing Reliable and Efficient
Software discusses and analyzes various designs, systems, and
advancements in software engineering. With its coverage on the
integration of mathematics, computer science, and practices in
engineering, this book highlights the importance of ensuring and
maintaining reliable software and is an essential resource for
practitioners, professors and students in these fields of study.
This book aims at exploring the skills set required for sustainable
employability of B.Tech students in India. In most of the
engineering colleges, students are from different academic
backgrounds coming from different places having different mother
tongues. So, there is a need to provide them a common platform to
make them competent to face the real challenges of today's
corporate world. English is the language which can remove the
lingual difference among them and give them medium to communicate.
Employability skills are very essential in the current global job
market. These skills may be termed as soft skills, which are given
utmost importance in campus interview. This book tries to list the
skills needed for engineering students to get employed in reputed
companies. In this book I have discussed empirical research work
done in an engineering college. According to me the students with
skills like positive attitude, effective communication, problem
solving, time management, team spirit, self confidence, handling
criticism, etc. which are also known as soft skills have much more
better chances of survival in this corporate world as compared to
students lacking soft skill. HSS ASR
Retailing in India is one of the pillars of its economy and
accounts for 14 to 15 percent of its GDP. India is one of the
fastest growing retail markets in the world, with 1.2 billion
people. India's retail and logistics industry, organized and
unorganized in combination, employs about 40 million Indians (3.3%
of Indian population). Retailing in India has remained in the
unorganized sector and largely untouched by corporates. Shopping
malls and new format stores are invariably becoming the visible
face of Indian retail growth. International as well as national
brands are available in these malls. Customers are becoming more
brand and price conscious. With the emergence of upper middle
class, the purchasing parity of consumers is changing. This class
wants the good quality goods but with some price considerations.
Private labeled goods meet this demand in a very good manner.
Therefore malls also offer private branded or in-house branded
goods, which are good in quality and less in price than national
brands. In this book, I have discussed marketing strategies applied
in retail sector. Authored by: Hardeep Singh Assistant Professor
R/O Amritsar - The Holy City (Punjab) INDIA.
This work offers a vivid journey into the medieval world of new
religions and changing sensibilities. This story is an
unforgettable tale about the cul de sacs of history, of pain and
memory, of hope and hate.
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