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This is the first book to assemble the leading researchers in the
field of LRRK2 biology and neurology and provide a snapshot of the
current state of knowledge, encompassing all major aspects of its
function and dysfunction. The contributors are experts in cell
biology and physiology, neurobiology, and medicinal chemistry,
bringing a multidisciplinary perspective on the gene and its role
in disease. The book covers the identification of LRRK2 as a major
contributor to the pathogenesis of Parkinson's Disease. It also
discusses the current state of the field after a decade of
research, putative normal physiological roles of LRRK2, and the
various pathways that have been identified in the search for the
mechanism(s) of its induction of neurodegeneration.
This is the first book to assemble the leading researchers in the
field of LRRK2 biology and neurology and provide a snapshot of the
current state of knowledge, encompassing all major aspects of its
function and dysfunction. The contributors are experts in cell
biology and physiology, neurobiology, and medicinal chemistry,
bringing a multidisciplinary perspective on the gene and its role
in disease. The book covers the identification of LRRK2 as a major
contributor to the pathogenesis of Parkinson's Disease. It also
discusses the current state of the field after a decade of
research, putative normal physiological roles of LRRK2, and the
various pathways that have been identified in the search for the
mechanism(s) of its induction of neurodegeneration.
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