Therapeutic Monoclonal Antibodies and Antibody Drug Conjugates (ADC): From Lot Release to Stability Testing is a highly topical resource on a subject of interest for scientists and researchers working on monoclonal antibodies' characterization, release testing, stability testing and similarity assessments of monoclonal antibodies in the biopharmaceutical industry. Monoclonal antibodies (mAbs) are large, extremely complex and dynamic biomolecules, so it can be challenging to develop well-characterized therapeutic antibodies that meet regulatory expectations that are also in-line with commercialized standards for different drug markets. Lot release testing and understanding the stability of the mAb over a period of time, and in different environmental conditions, is an indispensable aspect of mAb physicochemical characterization. This book covers the process, including extensive analysis that starts with quantifying the purity attribute to glycan profiling and identifying the mAb primary structure. The book has a primary purpose of focusing on both Lot release testing and stability testing of monoclonal antibodies (subjects not covered in any great detail in other books).

The internet of things (IoT) has massive potential to transform current business models and enhance human lifestyles. With the current pace of research, IoT will soon find many new horizons to touch. IoT is now providing a base of technological advancement in various realms such as pervasive healthcare, smart homes, smart cities, connected logistics, automated supply chain, manufacturing units, and many more. IoT is also paving the path for the emergence of the digital revolution in industrial technology, termed Industry 4.0. Transforming the Internet of Things for Next-Generation Smart Systems focuses on the internet of things (IoT) and how it is involved in modern day technologies in a variety of domains. The chapters cover IoT in sectors such as agriculture, education, business and management, and computer science applications. The multi-disciplinary view of IoT provided within this book makes it an ideal reference work for IT specialists, technologists, engineers, developers, practitioners, researchers, academicians, and students interested in how IoT will be implemented in the next generation of smart systems and play an integral role in advancing technology in the future.

This book attempts to create awareness about the UN-MDGs and how various ICT can be harnessed to appeal to different demographics. Current empirical evidence suggests that MDG awareness is relatively low particularly in developed countries, and that the levels of MDG awareness vary considerable across socioeconomic variables or demographics from United Nations perspective. It also examines how ICT can be used to bring about technical and social innovations strengthen livelihoods, support economic development, water and climate resilience and improve the education and health sectors and enhance development opportunities. Several studies are highlighted that reinforce the view that government support and private sector expertise and funding are important factors in ICT-based e-government solutions in developing countries. The book also builds on the thesis that a strong connection between competencies in mathematics, science, and information communication/technology is required to build logical concepts and critical thinking skills. It also examines the opportunities and barriers of promoting students' learning skills, including communication, cooperation, collaboration and connection using the Wiki tool under the blackboard platform. Finally, the book also highlights the challenges involved in application of ICT in education. This is significant for educators in order to surmount these obstacles and consequently successfully incorporate ICT into the educational system. The chapters present the relevant literature on ICTs and the perceived barriers to ICT integration in basic education. They also focus on the implications of incorporating ICT in the basic educational system. The challenges confronting the integration of ICT in education are equally identified with a view to ensuring a more efficient application of ICT in attaining education for all.

This book examines the role that Information and Communication Technologies (ICTs) play in growth and economic development promotion, specifically for developing countries. It highlights multiple methodologies for quantifying the impact of ICTs. This includes quantitative and qualitative methods, but also novel, conclusive and informative methodological approaches for measuring ICTs influence on economic development. The book highlights trends, perspectives, and success stories for different developing countries. ICTs bring new business models, innovations, capital-labor substitution, improved goods and services to developing markets. Because they can spread rapidly, with little cost and require minimal skills for usage, ICTs create a solid background for social and economic gains. They enable significant reduction in information asymmetries, which improves access to economic activities for multitude of agents, fostering participation, inter alias in labor market of disadvantaged societal groups. After almost two decades of rapid diffusion of ICT in developing world, this book seeks to assess the real benefits and consequences of ICTs adoption in developing countries. The chapters use broad, real-world based evidence to provide a better understanding of the precise nature of new technologies and their impact of the country`s economy and society.

This Springer book provides a perfect platform to submit chapters that discuss the prospective developments and innovative ideas in artificial intelligence and machine learning techniques in the diagnosis of COVID-19. COVID-19 is a huge challenge to humanity and the medical sciences. So far as of today, we have been unable to find a medical solution (Vaccine). However, globally, we are still managing the use of technology for our work, communications, analytics, and predictions with the use of advancement in data science, communication technologies (5G & Internet), and AI. Therefore, we might be able to continue and live safely with the use of research in advancements in data science, AI, machine learning, mobile apps, etc., until we can find a medical solution such as a vaccine. We have selected eleven chapters after the vigorous review process. Each chapter has demonstrated the research contributions and research novelty. Each group of authors must fulfill strict requirements.

Buying decision making is a complicated process, in which a consumer's decision is under the influence of others. The buyer's decision making is directed in such a way that they must act as a consumer in society. Media and family are key socializing agents for adolescents. Moreover, changes in the socio-cultural environment in India necessitate that adolescents' influence in family's buying decision making should be investigated. In comparison to Western society, Indian society is quite different when compared in terms of family composition and structure, behavior, values and norms which impact adolescents' buying decision making. Adolescents, Family and Consumer Behaviour studies the role of consumer socialization agents for adolescents, examining socio-economic factors that influence adolescents' buying decision making in Indian urban families. It aims to discover the influence tactics that adolescents employ and to qualitatively analyse how marketers in turn influence adolescents. It addresses the topics with regard to strategic management and marketing and will be of interest to researchers, academics, practitioners, and students in the fields of management, entrepreneurship, small business management, and human resource management.

Various Multiple Criteria Decision-Making (MCDM) techniques in one book: 13 MCDM techniques have been applied, namely, WSM, WPM, WASPAS, GRA, SMART, CRITIC, ENTROPY, EDAS, MOORA, AHP, TOPSIS, VIKOR, and new tools: MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR. To date, no other book possesses this many tools. Various quantitative techniques: Different quantitative techniques have been applied, namely, Cronbach alpha, Chi-square and ANOVA (for demographic analysis), Percent Point Score and Central Tendency (response analysis), Factor Analysis, Correlation and Regression. To date, no other book possesses this many tools. Interpretive Structural Modelling: ISM has been applied for verifying MCDM results through MICMAC analysis and ISM model thus paving the way for model through SEM. Structural Equation Modelling: SEM using AMOS in PASW has been applied for model development. New MCDM techniques developed: In the process during qualitative analysis, new tools have been developed and their results have been compared with other existing MCDM tools and the results are encouraging. The new techniques are MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR. Qualitative Model Developed: As the title says, Sustainable Green Development and Manufacturing Performance through Modern Production Techniques. It is a need-of-the-hour topic, as industries must maintain their performance (sustainable development) and, while sustaining, they have to keep in mind green issues (that is, environment-related issues, especially during the COVID-19 pandemic) and adopt advanced manufacturing and maintenance techniques. A model for this has been developed which will be helpful to both academicians and industrialists. Real-time Case Studies: Case studies in two industries of differing origins, different manufacturing sectors, different products, and comparing their units in the country of their origin and India. Dr. Chandan Deep Singh is an assistant professor in the Department of Mechanical Engineering, Punjabi University, Patiala, Punjab (India). He is a co-author of Adolescents, Family and Consumer Behaviour (Routledge, 2020) and of Manufacturing Competency and Strategic Success in the Automobile Industry (CRC Press, 2019). Dr. Harleen Kaur is a manager (HR) at DELBREC Industries, Pvt. Ltd., Chandigarh. She co-authored Adolescents, Family and Consumer Behaviour (Routledge, 2020).

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

Based on the IOM's estimate of 44,000 deaths annually, medical errors rank as the eighth leading cause of death in the U.S. Clearly medical errors are an epidemic that needs to be contained. Despite these numbers, patient safety and medical errors remain an issue for physicians and other clinicians. This book bridges the issues related to patient safety by providing clinically relevant, vignette-based description of the areas where most problems occur. Each vignette highlights a particular issue such as communication, human facturs, E.H.R., etc. and provides tools and strategies for improving quality in these areas and creating a safer environment for patients.

Based on the IOM's estimate of 44,000 deaths annually, medical errors rank as the eighth leading cause of death in the U.S. Clearly medical errors are an epidemic that needs to be contained. Despite these numbers, patient safety and medical errors remain an issue for physicians and other clinicians. This book bridges the issues related to patient safety by providing clinically relevant, vignette-based description of the areas where most problems occur. Each vignette highlights a particular issue such as communication, human facturs, E.H.R., etc. and provides tools and strategies for improving quality in these areas and creating a safer environment for patients.

This book examines the role that Information and Communication Technologies (ICTs) play in growth and economic development promotion, specifically for developing countries. It highlights multiple methodologies for quantifying the impact of ICTs. This includes quantitative and qualitative methods, but also novel, conclusive and informative methodological approaches for measuring ICTs influence on economic development. The book highlights trends, perspectives, and success stories for different developing countries. ICTs bring new business models, innovations, capital-labor substitution, improved goods and services to developing markets. Because they can spread rapidly, with little cost and require minimal skills for usage, ICTs create a solid background for social and economic gains. They enable significant reduction in information asymmetries, which improves access to economic activities for multitude of agents, fostering participation, inter alias in labor market of disadvantaged societal groups. After almost two decades of rapid diffusion of ICT in developing world, this book seeks to assess the real benefits and consequences of ICTs adoption in developing countries. The chapters use broad, real-world based evidence to provide a better understanding of the precise nature of new technologies and their impact of the country`s economy and society.

This book attempts to create awareness about the UN-MDGs and how various ICT can be harnessed to appeal to different demographics. Current empirical evidence suggests that MDG awareness is relatively low particularly in developed countries, and that the levels of MDG awareness vary considerable across socioeconomic variables or demographics from United Nations perspective. It also examines how ICT can be used to bring about technical and social innovations strengthen livelihoods, support economic development, water and climate resilience and improve the education and health sectors and enhance development opportunities. Several studies are highlighted that reinforce the view that government support and private sector expertise and funding are important factors in ICT-based e-government solutions in developing countries. The book also builds on the thesis that a strong connection between competencies in mathematics, science, and information communication/technology is required to build logical concepts and critical thinking skills. It also examines the opportunities and barriers of promoting students' learning skills, including communication, cooperation, collaboration and connection using the Wiki tool under the blackboard platform. Finally, the book also highlights the challenges involved in application of ICT in education. This is significant for educators in order to surmount these obstacles and consequently successfully incorporate ICT into the educational system. The chapters present the relevant literature on ICTs and the perceived barriers to ICT integration in basic education. They also focus on the implications of incorporating ICT in the basic educational system. The challenges confronting the integration of ICT in education are equally identified with a view to ensuring a more efficient application of ICT in attaining education for all.

Buying decision making is a complicated process, in which a consumer's decision is under the influence of others. The buyer's decision making is directed in such a way that they must act as a consumer in society. Media and family are key socializing agents for adolescents. Moreover, changes in the socio-cultural environment in India necessitate that adolescents' influence in family's buying decision making should be investigated. In comparison to Western society, Indian society is quite different when compared in terms of family composition and structure, behavior, values and norms which impact adolescents' buying decision making. Adolescents, Family and Consumer Behaviour studies the role of consumer socialization agents for adolescents, examining socio-economic factors that influence adolescents' buying decision making in Indian urban families. It aims to discover the influence tactics that adolescents employ and to qualitatively analyse how marketers in turn influence adolescents. It addresses the topics with regard to strategic management and marketing and will be of interest to researchers, academics, practitioners, and students in the fields of management, entrepreneurship, small business management, and human resource management.

This book is an essential guide on surrogacy, discussing various legal issues that arise in surrogacy cases. It provides a comprehensive coverage to various issues pertaining to surrogacy arrangements due to failure to meet the needs of those involved in surrogacy, be it the intended parents or the surrogate mother, with special emphasis on the most vulnerable party -- the surrogate child. In the wake of this existing imbalance, the call to reform the practice of surrogacy has also increased. The book provides a comprehensive coverage to various laws and policy regulations in existence dealing with surrogacy, and unravels the latest trends and developments happening around the world as surrogacy gains importance. The international perspectives highlight policies and practices being adopted and followed by various nations with regard to surrogacy regulation and associated parenthood rules. This book also analyses some of the significant cross-border disputes revolving around surrogacy, and explores briefly the jurisprudence of the European Court of Human Rights on matters of parentage and citizenship for children born of trans-national surrogacy with special reference to the prospects of a convention on international surrogacy currently being studied by The Hague Conference on Private International Law. Further, it highlights the issues and questions relating to surrogacy arrangements that are so far unresolved and unanswered and suggests measures for improvements to the existing proposed surrogacy legislation in India and need for uniform international regulation. The book is a great resource for legal practitioners, academics, students, policy-makers, infertility clinics, and charitable organizations working on this issue.

This Springer book provides a perfect platform to submit chapters that discuss the prospective developments and innovative ideas in artificial intelligence and machine learning techniques in the diagnosis of COVID-19. COVID-19 is a huge challenge to humanity and the medical sciences. So far as of today, we have been unable to find a medical solution (Vaccine). However, globally, we are still managing the use of technology for our work, communications, analytics, and predictions with the use of advancement in data science, communication technologies (5G & Internet), and AI. Therefore, we might be able to continue and live safely with the use of research in advancements in data science, AI, machine learning, mobile apps, etc., until we can find a medical solution such as a vaccine. We have selected eleven chapters after the vigorous review process. Each chapter has demonstrated the research contributions and research novelty. Each group of authors must fulfill strict requirements.

This book is an essential guide on surrogacy, discussing various legal issues that arise in surrogacy cases. It provides a comprehensive coverage to various issues pertaining to surrogacy arrangements due to failure to meet the needs of those involved in surrogacy, be it the intended parents or the surrogate mother, with special emphasis on the most vulnerable party -- the surrogate child. In the wake of this existing imbalance, the call to reform the practice of surrogacy has also increased. The book provides a comprehensive coverage to various laws and policy regulations in existence dealing with surrogacy, and unravels the latest trends and developments happening around the world as surrogacy gains importance. The international perspectives highlight policies and practices being adopted and followed by various nations with regard to surrogacy regulation and associated parenthood rules. This book also analyses some of the significant cross-border disputes revolving around surrogacy, and explores briefly the jurisprudence of the European Court of Human Rights on matters of parentage and citizenship for children born of trans-national surrogacy with special reference to the prospects of a convention on international surrogacy currently being studied by The Hague Conference on Private International Law. Further, it highlights the issues and questions relating to surrogacy arrangements that are so far unresolved and unanswered and suggests measures for improvements to the existing proposed surrogacy legislation in India and need for uniform international regulation. The book is a great resource for legal practitioners, academics, students, policy-makers, infertility clinics, and charitable organizations working on this issue.

The internet of things (IoT) has massive potential to transform current business models and enhance human lifestyles. With the current pace of research, IoT will soon find many new horizons to touch. IoT is now providing a base of technological advancement in various realms such as pervasive healthcare, smart homes, smart cities, connected logistics, automated supply chain, manufacturing units, and many more. IoT is also paving the path for the emergence of the digital revolution in industrial technology, termed Industry 4.0. Transforming the Internet of Things for Next-Generation Smart Systems focuses on the internet of things (IoT) and how it is involved in modern day technologies in a variety of domains. The chapters cover IoT in sectors such as agriculture, education, business and management, and computer science applications. The multi-disciplinary view of IoT provided within this book makes it an ideal reference work for IT specialists, technologists, engineers, developers, practitioners, researchers, academicians, and students interested in how IoT will be implemented in the next generation of smart systems and play an integral role in advancing technology in the future.

FACTORIES OF THE FUTURE The book provides insight into various technologies adopted and to be adopted in the future by industries and measures the impact of these technologies on manufacturing performance and their sustainability. Businesses and manufacturers face a slew of demands beyond the usual issues of staying agile and surviving in a competitive landscape within a rapidly changing world. Factories of the Future deftly takes the reader through the continuous technology changes and looks ten years down the road at what manufacturing will mostly look like. The book is divided into two parts: Emerging technologies and advancements in existing technologies. Emerging technologies consist of Industry 4.0 and 5.0 themes, machine learning, intelligent machining, advanced maintenance, reliability, and green manufacturing. The advances of existing technologies consist of digital manufacturing, artificial intelligence in machine learning, Internet of Things, product life cycle, and the impact of factories on the future of manufacturing performance of the manufacturing industries. Readers will find in this illuminating book: A comprehensive discussion of almost all emerging technologies, including “green” manufacturing; An overview of the social, economic, and technical aspects of these technologies; An explanation of these technological advancements on manufacturing performance, through case studies and other analytical tools.