Europeans, Africans, and American Indians practiced slavery long before the first purchase of a captive African by a white land-owner in the American colonies; that, however, is the image of slavery most prevalent in the minds of Americans today. This Very Short Introduction begins with the Portuguese capture of Africans in the 1400s and traces the development of American slavery until its abolition following the Civil War. Historian Heather Andrea Williams draws upon the rich recent scholarship of numerous highly-regarded academics as well as an analysis of primary documents to explore the history of slavery and its effects on the American colonies and later the United States of America. Williams examines legislation that differentiated American Indians and Africans from Europeans as the ideology of white supremacy flourished and became an ingrained feature of the society. These laws reflected the contradiction of America's moral and philosophical ideology that valorized freedom on one hand and justified the enslavement of a population deemed inferior on another. She explores the tense and often violent relationships between the enslaved and the enslavers, and between abolitionists and pro-slavery advocates as those who benefited from the institution fought to maintain and exert their power. Williams is attentive to the daily labors that enslaved people performed, reminding readers that slavery was a system of forced labor with economic benefits that produced wealth for a new nation, all the while leaving an indelible mark on its history.

In this previously untold story of African American self-education, Heather Andrea Williams moves across time to examine African Americans' relationship to literacy during slavery, during the Civil War, and in the first decades of freedom. Some slaves devised creative and subversive means to acquire literacy, and when slavery ended, they became the first teachers of other freedpeople. Williams argues that by teaching, building schools, supporting teachers, resisting violence, and claiming education as a civil right, African Americans transformed the face of education in the South to the great benefit of both black and white southerners.

After the Civil War, African Americans placed poignant ""information wanted"" advertisements in newspapers, searching for missing family members. Inspired by the power of these ads, Heather Andrea Williams uses slave narratives, letters, interviews, public records, and diaries to guide readers back to devastating moments of family separation during slavery when people were sold away from parents, siblings, spouses, and children. Williams explores the heartbreaking stories of separation and the long, usually unsuccessful journeys toward reunification. Examining the interior lives of the enslaved and freedpeople as they tried to come to terms with great loss, Williams grounds their grief, fear, anger, longing, frustration, and hope in the history of American slavery and the domestic slave trade. Williams follows those who were separated, chronicles their searches, and documents the rare experience of reunion. She also explores the sympathy, indifference, hostility, or empathy expressed by whites about sundered black families. Williams shows how searches for family members in the post-Civil War era continue to reverberate in African American culture in the ongoing search for family history and connection across generations.