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Metals Ions in Biological System - Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes: (Hardcover): Astrid... Metals Ions in Biological System - Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes: (Hardcover)
Astrid Sigel, Helmut Sigel
R12,161 Discovery Miles 121 610 Ships in 12 - 17 working days

Volume 39, devoted solely to the vital research area on molybdenum and tungsten and their role in biology, offers a comprehensive and timely account of this fascinating topic by 40 distinguished international authorities. With more than 2200 references to assist further research, Molybdenum and Tungsten: Their Roles in Biological Processes is an essential resource for scientists and students in many disciplines, including bioinorganic, inorganic, and coordination chemistry; biochemistry; biophysics; molecular biology; enzymology; pharmacology; physiology; clinical chemistry; nutrition; toxicology; and environmental sciences.

Metal Ions in Biological Systems - Volume 22: Endor: EPR, and Electron Spin Echo for Probing Coordination Spheres (Hardcover):... Metal Ions in Biological Systems - Volume 22: Endor: EPR, and Electron Spin Echo for Probing Coordination Spheres (Hardcover)
Helmut Sigel
R10,587 Discovery Miles 105 870 Ships in 12 - 17 working days

This volume focuses on the physical methods to probe the coordination sphere of metal ions in biological systems, which are based on para-magnetic species, namely, the electron nuclear double resonance (ENDOR), electron paramagnetic resonance (EPR), and electron spin echo (ESE) techniques.

Metals Ions in Biological System - Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes: (Paperback): Astrid... Metals Ions in Biological System - Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes: (Paperback)
Astrid Sigel, Helmut Sigel
R2,043 Discovery Miles 20 430 Ships in 12 - 17 working days

Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes is devoted soley to the vital research area on molybdenum and tungsten and their role in biology. It offers a comprehensive and timely account of this fascinating topic by 40 distinguished international authorities. Topics include: transport, homeostasis, regulation and binding of molybdate and tungstate to proteins, crystallographic characterization, coordination of complexes, and biosynthesis.

Metal Ions in Biological Systems - Volume 15: Zinc and its Role in Biology and Nutrition (Paperback): Helmut Sigel Metal Ions in Biological Systems - Volume 15: Zinc and its Role in Biology and Nutrition (Paperback)
Helmut Sigel
R1,901 Discovery Miles 19 010 Ships in 12 - 17 working days

This volume first considers the categories of zinc metalloenzymes, together with models of the enzymic metal-ion binding sites. It covers the nutritional aspects of zinc: its absorption and excretion, its influence on the activity of enzymes and hormones, and the zinc deficiency syndrome.

Metal Ions in Biological Systems - Volume 14: Inorganic Drugs in Deficiency and Disease (Paperback): Helmut Sigel Metal Ions in Biological Systems - Volume 14: Inorganic Drugs in Deficiency and Disease (Paperback)
Helmut Sigel
R1,313 Discovery Miles 13 130 Ships in 12 - 17 working days

This book describes drug metal-ion interactions in the gut and deals with the deficiency of zinc and iron and their pharmacological use. It covers anti-inflammatory activities of copper and gold complexes and considers the role of metal ions and chelating agents in anti-viral chemotherapy.

Metal Ions In Biological Systems, Volume 44 - Biogeochemistry, Availability, and Transport of Metals in the Environment... Metal Ions In Biological Systems, Volume 44 - Biogeochemistry, Availability, and Transport of Metals in the Environment (Paperback)
Helmut Sigel, Roland Sigel
R1,876 Discovery Miles 18 760 Ships in 12 - 17 working days

Volume 44, devoted solely to the vital research areas concerning the biogeochemistry of metals and their transport in the environment and availability to living systems, offers 9 timely and authoritative chapters on these fascinating topics by 19 internationally recognized experts.

Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Paperback): Helmut Sigel Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Paperback)
Helmut Sigel
R2,033 Discovery Miles 20 330 Ships in 12 - 17 working days

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology."

Metal Ions in Biological Systems - Volume 30: Metalloenzymes Involving Amino Acid-residue and Related Radicals (Hardcover,... Metal Ions in Biological Systems - Volume 30: Metalloenzymes Involving Amino Acid-residue and Related Radicals (Hardcover, illustrated edition)
Helmut Sigel, Astrid Sigel
R7,908 Discovery Miles 79 080 Ships in 12 - 17 working days

This volume is devoted solely to the research area of metalloenzymes involving amino acid-residue and related radicals. Topics covered include: general considerations; structure, function and engineering of peroxidases; and ribonucleotide reductase in mammalian systems.

Metal Ions in Biological Systems - Volume 29: Biological Properties of Metal Alkyl Derivatives (Hardcover): Helmut Sigel,... Metal Ions in Biological Systems - Volume 29: Biological Properties of Metal Alkyl Derivatives (Hardcover)
Helmut Sigel, Astrid Sigel
R3,162 Discovery Miles 31 620 Ships in 10 - 15 working days

This volume is devoted to the research area regarding the biological properties of metal alkyl derivatives, offering an authoritative account of this subject by 16 scientists. In 11 chapters, Biological Properties of Metal Alkyl Derivatives highlights, in detail, derivatives of germanium, tin, lead, arsenic, antimony, selenium, tellurium, cobalt (vitamin B12 derivatives) and nickel (coenzyme F430), including the role of (mainly) micro-organisms in their formation. The derivatives of indium, thallium, bismuth, various transition metals and mercury are also covered to some extent, as are those of the non-metals silicon, phosphorus and sulfur, and the haloperoxidase route of the biogenesis of halomethanes by fungi and plants. The properties of these alkyl derivatives, their biosynthesis, including mechanistic aspects, their appearance in waters (rivers, lakes, oceans) and sediments, and their physiological and toxic effects are summarized.

Metal Ions in Biological Systems - Volume 28: Degradation of Environmental Pollutants by Microorganisms and Their... Metal Ions in Biological Systems - Volume 28: Degradation of Environmental Pollutants by Microorganisms and Their Metalloenzymes (Hardcover)
Helmut Sigel, Astrid Sigel
R11,084 Discovery Miles 110 840 Ships in 10 - 15 working days

Continuing to explore the relationship between the chemistry of metals and life processes, this volume in the Metal Ions in Biological Systems series examines the degradation of environmental pollutants by micro-organisms. It covers the action of micro-organisms and metalloenzymes on lignin, tannins, hemicelluloses, cellulose and aromatic compounds, as well as on halogenated aromatics and aliphatics; analyzes mechanistic aspects; considers the role of metalloproteases in biotechnology and wastewater sludge treatment; and describes the metal-dependent conversion of inorganic nitrogen and sulfur compounds.

Metal Ions in Biological Systems - Volume 27: Electron Transfer Reactions in Metalloproteins (Hardcover, New): Helmut Sigel,... Metal Ions in Biological Systems - Volume 27: Electron Transfer Reactions in Metalloproteins (Hardcover, New)
Helmut Sigel, Astrid Sigel
R7,007 Discovery Miles 70 070 Ships in 12 - 17 working days

Part of a series devoted to understanding the relationship between the chemistry of metals and life processes, the present volume offers contributions by 25 scientists covering mechanistic considerations, electron tunneling pathways, photoinduced and stereoselective effects in electron transfer reac

Metal Ions in Biological Systems - Volume 26: Compendium on Magnesium and Its Role in Biology: Nutrition and Physiology... Metal Ions in Biological Systems - Volume 26: Compendium on Magnesium and Its Role in Biology: Nutrition and Physiology (Hardcover, New)
Helmut Sigel, Astrid Sigel
R7,631 Discovery Miles 76 310 Ships in 12 - 17 working days

Thirty chapters provide a handbook-like treatment of magnesium and its function in the environment, its bioinorganic chemistry, its role for plants and in animal and human nutrition, its biochemistry and physiology, and its relation to human health and disease. The last 20 years have seen a prolifer

Metal Ions in Biological Systems - Volume 23: Nickel and its Role in Biology (Hardcover): Helmut Sigel, Astrid Sigel Metal Ions in Biological Systems - Volume 23: Nickel and its Role in Biology (Hardcover)
Helmut Sigel, Astrid Sigel
R7,306 Discovery Miles 73 060 Ships in 12 - 17 working days

This book considers nickel in the environment and in aquatic systems and outlines its role for plants. It discusses the toxicology of nickel compounds and the role of nickel in carcinogenesis, focusing on the analysis of nickel in biological materials and the related difficulties.

Metal Ions in Biological Systems - Volume 21: Applications of Magnetic Resonance to Paramagnetic Species (Hardcover,... Metal Ions in Biological Systems - Volume 21: Applications of Magnetic Resonance to Paramagnetic Species (Hardcover, illustrated edition)
Helmut Sigel
R3,378 Discovery Miles 33 780 Ships in 10 - 15 working days

This book facilitates a wider use of nuclear magnetic resonance in studies of paramagnetic species. It summarizes studies of magnetically coupled metalloproteins, of paramagnetic heme proteins, and of metal-porphyrin-induced dipolar shifts for conformational analysis.

Metal Ions in Biological Systems - Volume 19: Antibiotics and Their Complexes (Hardcover, illustrated edition): Helmut Sigel Metal Ions in Biological Systems - Volume 19: Antibiotics and Their Complexes (Hardcover, illustrated edition)
Helmut Sigel
R3,416 Discovery Miles 34 160 Ships in 10 - 15 working days

This volume is an attempt to improve the understanding of the coordination chemistry and action of the biologically important compounds, also termed antibiotics, and to stimulate further research in this area, describing the properties of the biologically important compounds.

Metal Ions in Biological Systems - Volume 17: Calcium and its Role in Biology (Hardcover): Helmut Sigel Metal Ions in Biological Systems - Volume 17: Calcium and its Role in Biology (Hardcover)
Helmut Sigel
R7,310 Discovery Miles 73 100 Ships in 12 - 17 working days

This book is wholly devoted to Ca2+ metal ion, as it is so important in regulating a wide variety of biological activities. It deals with calcium and brain proteins, the role of ca2+ in exocytosis, blood coagulation, and the regulation of the skeletal muscle contraction-relaxation cycle.

Metal Ions in Biological Systems - Volume 15: Zinc and its Role in Biology and Nutrition (Hardcover, illustrated edition):... Metal Ions in Biological Systems - Volume 15: Zinc and its Role in Biology and Nutrition (Hardcover, illustrated edition)
Helmut Sigel
R8,823 Discovery Miles 88 230 Ships in 12 - 17 working days

"Metal Ions in Biological Systems" is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine.

"Volume 43" focuses on the vibrant research area concerning the cycling of elements, metals, and non-metals in biology and geology; in 10 chapters this book offers an authoritative and timely account on this fascinating subject.

Metal Ions in Biological Systems - Volume 14: Inorganic Drugs in Deficiency and Disease (Hardcover): Helmut Sigel Metal Ions in Biological Systems - Volume 14: Inorganic Drugs in Deficiency and Disease (Hardcover)
Helmut Sigel
R6,394 Discovery Miles 63 940 Ships in 12 - 17 working days

This book describes drug metal-ion interactions in the gut and deals with the deficiency of zinc and iron and their pharmacological use. It covers anti-inflammatory activities of copper and gold complexes and considers the role of metal ions and chelating agents in anti-viral chemotherapy.

Metal Ions in Biological Systems - Volume 9: Amino Acids and Derivatives as Ambivalent Ligands (Hardcover): Helmut Sigel Metal Ions in Biological Systems - Volume 9: Amino Acids and Derivatives as Ambivalent Ligands (Hardcover)
Helmut Sigel
R2,854 Discovery Miles 28 540 Ships in 10 - 15 working days

This book focuses on the connection between the chemistry of metal ions and their role for life, and covers complexes with a number of amino acids with chelatable side chain donor atoms. It discusses metal ion-protein interactions and the ligating ambivalency of nucleotides.

Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Hardcover): Helmut Sigel Metal Ions in Biological Systems - Volume 37: Manganese and Its Role in Biological Processes (Hardcover)
Helmut Sigel
R12,155 Discovery Miles 121 550 Ships in 12 - 17 working days

"Highlights the availability of magnesium to organisms, its uptake and transport in microorganisms and plants as well as its role in health and disease of animals and humans including its toxicology."

Interrelations between Essential Metal Ions and Human Diseases (Paperback, Softcover reprint of the original 1st ed. 2013):... Interrelations between Essential Metal Ions and Human Diseases (Paperback, Softcover reprint of the original 1st ed. 2013)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R7,598 Discovery Miles 75 980 Ships in 10 - 15 working days

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Structural and Catalytic Roles of Metal Ions in RNA (Hardcover): Astrid Sigel, Helmut Sigel, Roland K.O. Sigel Structural and Catalytic Roles of Metal Ions in RNA (Hardcover)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R3,796 Discovery Miles 37 960 Ships in 10 - 15 working days

The discovery of ribozymes nearly 30 years ago triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in MILS 9. This book, written by 28 internationally recognized experts from 8 nations, provides a most up-to-date view and is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes in an authoritative and timely manner in 12 stimulating chapters, supported by nearly 1600 references, 13 tables, and 75 illustrations, mostly in color, metal ion-binding motifs, methods to detect and characterize metal ion-binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered.

Organometallics in Environment and Toxicology (Hardcover): Astrid Sigel, Helmut Sigel, Roland K.O. Sigel Organometallics in Environment and Toxicology (Hardcover)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R3,852 Discovery Miles 38 520 Ships in 10 - 15 working days

Volume 7, devoted to the vital and rapidly expanding research area around metal-carbon bonds (see also MILS-6), focuses on the environment. With more than 2500 references, 35 tables, and nearly 50 illustrations, many of these in color, it is an essential resource for scientists working in the wide range from organometallic chemistry, inorganic biochemistry, environmental toxicology all the way through to physiology and medicine. In 14 stimulating chapters, written by 29 internationally recognized experts, Organometallics in Environment and Toxicology highlights in an authoritative and timely manner environmental cycles of elements involving organometal(loid) compounds as well as the analytical determination of such species. This book examines methane formation involving the nickel coenzyme F430, as well as the organometal(loid) compounds formed by tin, lead, arsenic, antimony, bismuth, selenium, tellurium, and mercury. In addition, it deals with the environmental bioindication, biomonitoring, and bioremediation of organometal(loid)s, and it terminates with methylated metal(loid) species occurring in humans by evaluating assumed and proven health effects caused by these compounds.

Metal-Carbon Bonds in Enzymes and Cofactors (Hardcover): Astrid Sigel, Helmut Sigel, Roland K.O. Sigel Metal-Carbon Bonds in Enzymes and Cofactors (Hardcover)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R3,834 Discovery Miles 38 340 Ships in 10 - 15 working days

The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.

Metal Ions in Toxicology: Effects, Interactions, Interdependencies (Hardcover): Astrid Sigel, Helmut Sigel, Roland K.O. Sigel Metal Ions in Toxicology: Effects, Interactions, Interdependencies (Hardcover)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R3,813 Discovery Miles 38 130 Ships in 10 - 15 working days

Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment, for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic, and environmental biochemistry all the way through to toxicology, physiology, and medicine. Volume 8 highlights, supported by nearly 1900 references, in a comprehensive and timely manner the principles of risk assessment regarding the effects of metals on human health. It examines how metal ions and their compounds affect the pulmonary, cardiovascular, gastrointestinal (including liver), hematological, immune, and neurological systems, the kidney, skin and eyes, as well as human reproduction and development. MILS-8 terminates with the role of metal ions as endocrine disrupters, in genotoxicity, and cancer risk.

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