MILS-13 provides an up-to-date review on the relationships between
essential metals and human diseases, covering 13 metals and 3
metalloids: The bulk metals sodium, potassium, magnesium, and
calcium, plus the trace elements manganese, iron, cobalt, copper,
zinc, molybdenum, and selenium, all of which are essential for
life. Also covered are chromium, vanadium, nickel, silicon, and
arsenic, which have been proposed as being essential for humans in
the 2nd half of the last century. However, if at all, they are
needed only in ultra-trace amounts, and because of their prevalence
in the environment, it has been difficult to prove whether or not
they are required. In any case, all these elements are toxic in
higher concentrations and therefore, transport and cellular
concentrations of at least the essential ones, are tightly
controlled; hence, their homeostasis and role for life, including
deficiency or overload, and their links to illnesses, including
cancer and neurological disorders, are thoroughly discussed.
Indeed, it is an old wisdom that metals are indispensable for life.
Therefore, Volume 13 provides in an authoritative and timely manner
in 16 stimulating chapters, written by 29 internationally
recognized experts from 7 nations, and supported by more than 2750
references, and over 20 tables and 80 illustrations, many in color,
a most up-to-date view on the vibrant research area of the
Interrelations between Essential Metal Ions and Human Diseases.
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