This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1-10 to create the prostate cancer vaccine candidate, which is combined with -galactosylceramide C1, its analogue C34, or Alu. The results of the vaccination studies in mice are also described and indicate that the strongest anti-RM2 antigen titer is exhibited when one molecule of diphtheria toxin (DT) is conjugated with an average of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. More importantly, the induced mouse antibodies mediate the effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap. The study presented in this thesis is the first ever to successfully synthesize this complex glycan molecule. Owing to the steric hindrance of the adjacent sialyl moiety, the introduction of two sialic acid units to the compact and rigid 3,4 di branched galactoside unit is very challenging and the -selective and efficient glycosylation of the galactosamine moiety at the 4-position of di branched galactose is also problematic.

This book offers essential information on China's human spacecraft technologies, reviewing their evolution from theoretical and engineering perspectives. It discusses topics such as the design of manned spaceships, cargo spacecraft, space laboratories, space stations and manned lunar and Mars detection spacecraft. It also addresses various key technologies, e.g. for manned rendezvous, docking and reentry. The book is chiefly intended for researchers, graduate students and professionals in the fields of aerospace engineering, control, electronics & electrical engineering, and related areas.

This book is concerned with the fault estimation problem for network systems. Firstly, to improve the existing adaptive fault estimation observer, a novel so-called intermediate estimator is proposed to identify the actuator or sensor faults in dynamic control systems with high accuracy and convergence speed. On this basis, by exploiting the properties of network systems such as multi-agent systems and large-scale interconnected systems, this book introduces the concept of distributed intermediate estimator; faults in different nodes can be estimated simultaneously; meanwhile, satisfactory consensus performances can be obtained via compensation based protocols. Finally, the characteristics of the new fault estimation methodology are verified and discussed by a series of experimental results on networked multi-axis motion control systems. This book can be used as a reference book for researcher and designer in the field of fault diagnosis and fault-tolerant control and can also be used as a reference book for senior undergraduate and graduate students in colleges and universities.

Written by pioneers of the concept, this is the first complete guide to the physical and engineering principles of Massive MIMO. Assuming only a basic background in communications and statistical signal processing, it will guide readers through key topics in multi-cell systems such as propagation modeling, multiplexing and de-multiplexing, channel estimation, power control, and performance evaluation. The authors' unique capacity-bounding approach will enable readers to carry out effective system performance analyses and develop advanced Massive MIMO techniques and algorithms. Numerous case studies, as well as problem sets and solutions accompanying the book online, will help readers put knowledge into practice and acquire the skill set needed to design and analyze complex wireless communication systems. Whether you are a graduate student, researcher, or industry professional working in the field of wireless communications, this will be an indispensable guide for years to come.

Linear Systems: Non-Fragile Control and Filtering presents the latest research results and a systematic approach to designing non-fragile controllers and filters for linear systems. The authors combine the algebraic Riccati technique, the linear matrix inequality (LMI) technique, and the sensitivity analysis method to establish a set of new non-fragile (insensitive) control methods. This proposed method can optimize the closed-loop system performance and make the designed controllers or filters tolerant of coefficient variations in controller or filter gain matrices. A Systematic Approach to Designing Non-Fragile Controllers and Filters for Linear Systems The text begins with developments and main research methods in non-fragile control. It then systematically presents novel methods for non-fragile control and filtering of linear systems with respect to additive/multiplicative controller/filter gain uncertainties. The book introduces the algebraic Riccati equation technique to solve additive/multiplicative norm-bounded controller/filter gain uncertainty, and proposes a structured vertex separator to deal with the numerical problem resulting from interval-bounded coefficient variations. It also explains how to design insensitive controllers and filters in the framework of coefficient sensitivity theory. Throughout, the book includes numerical examples to demonstrate the effectiveness of the proposed design methods. More Effective Design Methods for Non-Fragile Controllers and Filters The design and analysis tools described will help readers to better understand and analyze parameter uncertainties and to design more effective non-fragile controllers and filters. Providing a coherent approach, this book is a valuable reference for researchers, graduate students, and anyone who wants to explore the area of non-fragile control and filtering.

The plant fossil record provides evidence that the genus Metasequoia was widely distributed and experienced a wide range of climatic and environmental conditions throughout the Northern Hemisphere from the early Late Cretaceous to the Plio-Pleistocene. Today the genus is limited to one species with approximately 5,000 mature individuals growing in the Xiahoe Valley in southeastern China. This book is a distillation of the collective efforts and results of the worlda (TM)s Metasequoia specialists and enthusiasts. It is the most up-to-date and comprehensive reference source for the genus and the authors have sought to incorporate obscure, hard-to-get and non-English reference sources. The book reviews what is known about the biology, ecology and physiology of fossil and living Metasequoia, current research directions and problems that remain unresolved.

This book presents a definitive overview of fossil and living Metasequoia and was written by sixteen of the worlda (TM)s experts on this important genus. Given the reality of increasing human pressure and the inevitability of global change, efforts to conserve this ancient genus are underway. This book will be of interest to botanists, geologists, paleobotanists, biogeographers, foresters, ecologists, paleoecologists, ecophysiologists, geochemists, climate modelers, geneticists, naturalists, science historians, and gardeners and will be useful as a supplemental text for advanced undergraduate and graduate level courses in paleoecology.

This three-volume set constitues selected papers presented during the 17th International Conference on Computer Science and Education, ICCSE 2022, held in Ningbo, China, in August 2022. The 168 full papers and 43 short papers presented were thoroughly reviewed and selected from the 510 submissions. They focus on a wide range of computer science topics, especially AI, data science, and engineering, and technology-based education, by addressing frontier technical and business issues essential to the applications of data science in both higher education and advancing e-Society.

This book collects and organizes the original studies presented at PROMS 2014 conference on theories and applications of Rasch model. It provides useful examples of the Rasch model used to address practical measurement problems across a range of different disciplines including: Item Response Theory (IRT), philosophy of measurement, dimensionality, the role of fit statistics and residuals, application, educational application, language testing, health related research, business and industrial application and Rasch-based computer software. PROMS 2014 (Pacific Rim Objective Measurement Symposium) was held August 2 - 6, 2014 in Guangzhou, China. The goal of this conference is to bring together the researchers from academia, universities, hospitals, industry, management sector as well as practitioners to share ideas, problems and solutions relating to the multifaceted aspects of Rasch Model.

The plant fossil record indicates that the genus Metasequoia was widely distributed throughout the Northern Hemisphere from the early Late Cretaceous to the Plio-Pleistocene. Today the genus has shrunk to one species with approximately 5,000 mature individuals in southeastern China's Xiahoe Valley. This book distills the current understanding of the biology, ecology and physiology of fossil and living Metasequoia, current research directions and problems that remain unresolved.

This three-volume set constitues selected papers presented during the 17th International Conference on Computer Science and Education, ICCSE 2022, held in Ningbo, China, in August 2022. The 168 full papers and 43 short papers presented were thoroughly reviewed and selected from the 510 submissions. They focus on a wide range of computer science topics, especially AI, data science, and engineering, and technology-based education, by addressing frontier technical and business issues essential to the applications of data science in both higher education and advancing e-Society.

This three-volume set constitues selected papers presented during the 17th International Conference on Computer Science and Education, ICCSE 2022, held in Ningbo, China, in August 2022. The 168 full papers and 43 short papers presented were thoroughly reviewed and selected from the 510 submissions. They focus on a wide range of computer science topics, especially AI, data science, and engineering, and technology-based education, by addressing frontier technical and business issues essential to the applications of data science in both higher education and advancing e-Society.

This book offers essential information on China's human spacecraft technologies, reviewing their evolution from theoretical and engineering perspectives. It discusses topics such as the design of manned spaceships, cargo spacecraft, space laboratories, space stations and manned lunar and Mars detection spacecraft. It also addresses various key technologies, e.g. for manned rendezvous, docking and reentry. The book is chiefly intended for researchers, graduate students and professionals in the fields of aerospace engineering, control, electronics & electrical engineering, and related areas.

Entrusted by the Board of Management of the Pacific Rim Objective Measurement Symposium (PROMS), PROMS2012 is held in Jiaxing, China from August 6-9, 2012. Over the past years, PROMS has been hosted in many parts of the Pacific Rim, in Singapore, Malaysia, Hong Kong, Taiwan and Tokyo, which has greatly promoted the research of and contributed to the development of Rasch Model in one way or another. As early as in 1980s, the ideas and concepts regarding IRT was first introduced into China by Prof. Gui Shichun, my Ph.D supervisor, and it is Prof. Gui who first conducted with great success the ten-year long (1990-1999) Equating Project for Matriculation English Test (MET) in China. MET is the most influential entrance examination for higher education administered annually to over 3.3 million candidates then. The Equating Project won recognition by Charles Alderson and other foreign counterparts during 1990s. Academically, those were Good Old Days for Chinese testing experts and psychometricians. Then for certain reasons, the equating practice abruptly discontinued. Therefore, in China nowadays, the application of IRT-based software like BILOG, Parscale, Iteman 4 and others to real testing problem solving is confined to an extremely small 'band' of people. In this sense, PROMS2012 meets an important need in that it provides an excellent introduction of IRT and its application. And anyone who is seriously interested in research and development in the field of psychometrics or language testing will find such a symposium and related workshops to be an excellent source of information about the application of Rasch Model. PROMS2012 focuses on recent advances in objective measurement and provides an international forum on both the latest research in using Rasch measurement and non-Rasch practice.