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The book gathers lecture notes of courses given at the 2014 summer
school on integrated biology in Les Houches, France, Session CII.
It addresses an emerging field ranging from molecules to cells and
to organisms. Through examples it presents a new way of thinking
using a combination of interdisciplinary and cutting-edge methods,
bridging physics and biology beyond current biophysics. Important
novel developments are expected in the coming years that may well
introduce paradigm shifts in biological science. The school had the
ambition to prepare participants to become major actors in these
breakthroughs. The power of integrated approaches is illustrated
through two cases: interactions between viruses and host cells, and
flower development. The role of forces in biology, as well as their
mathematical modeling, is illustrated in both processes: how they
allow flower organs to emerge or how they control membrane fusion
during virus budding. The book also underlines the importance of
conformational changes and dynamics of proteins particularly during
membrane processes. It explains how membrane proteins can be
handled and studied by molecular simulations. Finally, the book
also contains concepts in cell biology, in thermodynamics and
several novel approaches such as in-cell NMR. Altogether, the
chapters show how examining a biological system from different
viewpoints based on multidisciplinary aspects often leads to
enriching controversial arguments.
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