Uptime describes the combination of activities that deliver fewer breakdowns, improved productive capacity, lower costs, and better environmental performance. The bestselling second edition of Uptime has been used as a textbook on maintenance management in several postsecondary institutions and by many companies as the model framework for their maintenance management programs.

Following in the tradition of its bestselling predecessors, Uptime: Strategies for Excellence in Maintenance Management, Third Edition explainshow to deal with increasingly complex technologies, such as mobile and cloud computing, to support maintenance departments and set the stage for compliance with international standards for asset management.

This updated edition reflects a far broader and deeper wealth of experience and knowledge. In addition, it restructures its previous model of excellence slightly to align what must be done more closely with how to do it.

The book provides a strategy for developing and executing improvement plans that work well with the new values prevalent in today's workforce. It also explains how you can use seemingly competing improvement tools to complement and enhance each other.

This edition also highlights action you can take to compensate for the gradual loss of skills in the current workforce as "baby boomers" retire.

Table of Contents

LEADERSHIP

Building a Maintenance Strategy

Business of Maintenance Management

Framework for the Strategy

Strategy Components

Strategy Development

Developing the Vision

Maintenance Review

Closing the Gap—Planning Implementation

Contract Maintenance

Uptime Summary

Endnotes

People and Teamwork

People Really Are Your Most Important Asset

Teams

Managing Change

Organizing the Maintenance Structure

Multiskilling

Learning, Training, and Development

ESSENTIALS

Work Management

Work Management Cycle

Six Key Steps

Planning Horizons

Shutdown Management

Planning and Scheduling Tools

Planning Standards

Mobile Workforce Management

Uptime Summary

Endnotes

Basic Care

The Minimum Is Not Always Enough

Beyond the Minimum: Basic Care

5S Asset Management Housekeeping Excellence

5S Audits

Before you Start 5S

Uptime Summary

Materials Management

Planning, Scheduling, and Materials Management

E-Business

MRO Improvements

Uptime Summary

5

Endnote

Performance Management

Measuring Maintenance

Benchmarking Maintenance

Uptime Summary

Endnotes

Management and Support Systems for Maintenance

Systems Are Not Replacements for Strategy

What Management Systems Should Do

Different Types of Management Systems

Specialized Support Systems

Implementation Considerations

Justifying Your CMMS

Hardware and Software Tools: An Overview

Where Are We Headed with Systems?

Uptime Summary

Endnotes

CHOOSING EXCELLENCE

Asset Reliability 1: Being Proactive

Reliability-Centered Maintenance

Business of Maintenance Management

Simplified RCM Methods

Implementing RCM Successfully

Uptime Summary

Endnotes

Reliability Approaches 2: Quick Start and Continuous Improvement

Preventive Maintenance Optimization

Reliability and Simulation Modeling

Uptime Summary

Endnotes

Evidence-Based Asset Management

Evidence-Based Asset Management

Optimizing Life-Cycle Costing Decisions

Economic Life of an Asset

Optimizing Maintenance Tactics

Calculating Spare-Part Requirements

Optimizing Failure-Finding Intervals

Uptime Summary

ASSET MANAGEMENT

Asset Management

What Is Asset Management?

Standards, "Anatomy," and "Landscape"

Documentation, Record Keeping, and Information Management

Certification

Putting Uptime in an Asset Management Context

Uptime Summary

Information Management and Governance

Defining the Aim Program

Uptime Summary

THE JOURNEY

Implementing Uptime

Why Bother?

Getting there—Implementing Uptime

Assessments vs. Training

A New Approach

Planning

Governance

Initiative Overload

Action Teams

Middle Management

Just Do It

Sustainability

Uptime Summary

Conclusion

Endnotes

Bibliography

Appendix A: The Uptime Assessment

Appendix B: Glossary of Maintenance Terminology

Appendix C: Rapid Preventive Maintenance (PM) Deployment

Suggestions

Index

Continuing a long tradition, Lu's Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology. The book consists of four parts (Part I-Part IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final section (Part IV) on the toxic effects of chemicals and risk assessment, giving toxicologists, both students and practicing professionals, the necessary tools to enhance their practice. This edition includes new chapters on Clinical Toxicology, Systems Toxicology, Chemicals and Children, and Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as the other chapters in the book. With separate subject and chemical indexes, this is a useful, quick shelf reference for everyone working in toxicology today.

Continuing a long tradition, Lu’s Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology.

The book consists of four parts (Part I–Part IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final section (Part IV) on the toxic effects of chemicals and risk assessment, giving toxicologists, both students and practicing professionals, the necessary tools to enhance their practice. This edition includes new chapters on Clinical Toxicology, Systems Toxicology, Chemicals and Children, and Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as the other chapters in the book. With separate subject and chemical indexes, this is a useful, quick shelf reference for everyone working in toxicology today.

Table of Contents

PART I: General Principles of Toxicology. History of Toxicology. Absorption, Distribution, and Excretion of Toxicants. Metabolism of Toxicants. Toxic Effects (Mechanisms of Toxic Effects). Modifying Factors of Toxic Effects. Conventional Toxicity Studies. Systems Toxicology. PART II: Testing Procedures for Nontarget Organ Toxicities. Carcinogenesis. Mutagenesis. Developmental Toxicology. Lactation. PART III: Target Organs and Systems. Toxicology of the Liver. Toxicology of the Kidney. Toxicology of the Immune System. Respiratory System Inhalation Toxicology. Toxicology of the Skin. Toxicology of the Eye. Toxicology of the Nervous System. Cardiovascular System. Toxicology of Reproductive Systems. Toxicology of the Endocrine System. PART IV: Toxic Substances and Risk Assessment. Food Additives and Contaminants. Toxicity of Pesticides. Nanotoxicology. Toxicity of Metals. Environmental Pollutants. Occupational Toxicology. Chemicals and Children. Clinical Toxicology. Risk Assessment and Regulatory Toxicology.